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Yaws

MedGen UID:
12186
•Concept ID:
C0043388
•
Disease or Syndrome
Synonyms: Endemic treponematoses; Frambesia; Frambesia tropica; Treponema pertenue infection
SNOMED CT: Yaws (70647001); Frambesia (70647001); Pian (70647001); Buba (70647001); Infection by Treponema pertenue (70647001)
 
Monarch Initiative: MONDO:0006019

Definition

An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease. [from NCI]

Professional guidelines

PubMed

Mass Treatment with Single-Dose Azithromycin for Yaws.
Tepper M, Whitehead J, Maher M
N Engl J Med 2016 Sep 15;375(11):1093-4. doi: 10.1056/NEJMc1503442. PMID: 27626527
Progress in treatment and diagnosis of yaws: hope for eradication?
Stamm LV
Lancet Glob Health 2014 Jul;2(7):e369-70. Epub 2014 May 31 doi: 10.1016/S2214-109X(14)70248-7. PMID: 25103375
New treatment schemes for yaws: the path toward eradication.
Mitjà O, Hays R, Rinaldi AC, McDermott R, Bassat Q
Clin Infect Dis 2012 Aug;55(3):406-12. Epub 2012 May 18 doi: 10.1093/cid/cis444. PMID: 22610931

Recent clinical studies

Etiology

Yaws, Haemophilus ducreyi, and Other Bacterial Causes of Cutaneous Ulcer Disease in the South Pacific Islands.
G-Beiras C, Ubals M, Corbacho-Monné M, Vall-Mayans M, Mitjà O
Dermatol Clin 2021 Jan;39(1):15-22. Epub 2020 Oct 31 doi: 10.1016/j.det.2020.08.002. PMID: 33228858
Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Neglected tropical diseases: elimination and eradication.
Bodimeade C, Marks M, Mabey D
Clin Med (Lond) 2019 Mar;19(2):157-160. doi: 10.7861/clinmedicine.19-2-157. PMID: 30872302Free PMC Article
Neglected tropical diseases of Oceania: review of their prevalence, distribution, and opportunities for control.
Kline K, McCarthy JS, Pearson M, Loukas A, Hotez PJ
PLoS Negl Trop Dis 2013;7(1):e1755. Epub 2013 Jan 31 doi: 10.1371/journal.pntd.0001755. PMID: 23383349Free PMC Article
Yaws.
Browne SG
Int J Dermatol 1982 May;21(4):220-3. doi: 10.1111/j.1365-4362.1982.tb02079.x. PMID: 7095951

Diagnosis

Novel Diagnostics for Kaposi Sarcoma and Other Skin Diseases in Resource-Limited Settings.
McMahon DE, Oyesiku L, Semeere A, Kang D, Freeman EE
Dermatol Clin 2021 Jan;39(1):83-90. Epub 2020 Oct 31 doi: 10.1016/j.det.2020.08.008. PMID: 33228864Free PMC Article
Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Yaws.
Marks M, Mitjà O, Solomon AW, Asiedu KB, Mabey DC
Br Med Bull 2015;113(1):91-100. Epub 2014 Dec 18 doi: 10.1093/bmb/ldu037. PMID: 25525120Free PMC Article
Endemic treponematosis: review and update.
Farnsworth N, Rosen T
Clin Dermatol 2006 May-Jun;24(3):181-90. doi: 10.1016/j.clindermatol.2005.11.004. PMID: 16714199
History of syphilis.
Rothschild BM
Clin Infect Dis 2005 May 15;40(10):1454-63. Epub 2005 Apr 1 doi: 10.1086/429626. PMID: 15844068

Therapy

Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
A second chance.
Enserink M
Science 2018 Jul 20;361(6399):216-221. doi: 10.1126/science.361.6399.216. PMID: 30026209
Trachoma and Yaws: Common Ground?
Solomon AW, Marks M, Martin DL, Mikhailov A, Flueckiger RM, Mitjà O, Asiedu K, Jannin J, Engels D, Mabey DC
PLoS Negl Trop Dis 2015 Dec;9(12):e0004071. Epub 2015 Dec 3 doi: 10.1371/journal.pntd.0004071. PMID: 26633176Free PMC Article
Yaws.
Marks M, Mitjà O, Solomon AW, Asiedu KB, Mabey DC
Br Med Bull 2015;113(1):91-100. Epub 2014 Dec 18 doi: 10.1093/bmb/ldu037. PMID: 25525120Free PMC Article
Yaws.
Marks M, Lebari D, Solomon AW, Higgins SP
Int J STD AIDS 2015 Sep;26(10):696-703. Epub 2014 Sep 4 doi: 10.1177/0956462414549036. PMID: 25193248Free PMC Article

Prognosis

Hand Infections: Epidemiology and Public Health Burden.
Gundlach BK, Sasor SE, Chung KC
Hand Clin 2020 Aug;36(3):275-283. doi: 10.1016/j.hcl.2020.03.001. PMID: 32586453Free PMC Article
Syphilis in the United States.
Shockman S, Buescher LS, Stone SP
Clin Dermatol 2014 Mar-Apr;32(2):213-8. doi: 10.1016/j.clindermatol.2013.08.005. PMID: 24559556
Outcome predictors in treatment of yaws.
Mitjà O, Hays R, Ipai A, Gubaila D, Lelngei F, Kirara M, Paru R, Bassat Q
Emerg Infect Dis 2011 Jun;17(6):1083-5. doi: 10.3201/eid/1706.101575. PMID: 21749808Free PMC Article
The return of yaws.
Asiedu K
Bull World Health Organ 2008 Jul;86(7):507-8. doi: 10.2471/blt.08.040708. PMID: 18670660Free PMC Article
Syphilis control in populations previously exposed to yaws.
Hart G
Int J Epidemiol 1982 Jun;11(2):181-7. doi: 10.1093/ije/11.2.181. PMID: 7095969

Clinical prediction guides

Detection of cutaneous leishmaniasis in three communities of Oti Region, Ghana.
Akuffo R, Sanchez C, Chicharro C, Carrillo E, Attram N, Mosore MT, Yeboah C, Kotey NK, Boakye D, Ruiz-Postigo JA, Moreno J, Wilson M, Sarfo B, Anto F
PLoS Negl Trop Dis 2021 May;15(5):e0009416. Epub 2021 May 24 doi: 10.1371/journal.pntd.0009416. PMID: 34029326Free PMC Article
Outcome predictors in treatment of yaws.
Mitjà O, Hays R, Ipai A, Gubaila D, Lelngei F, Kirara M, Paru R, Bassat Q
Emerg Infect Dis 2011 Jun;17(6):1083-5. doi: 10.3201/eid/1706.101575. PMID: 21749808Free PMC Article
Syphilis control in populations previously exposed to yaws.
Hart G
Int J Epidemiol 1982 Jun;11(2):181-7. doi: 10.1093/ije/11.2.181. PMID: 7095969
Attenuated yaws in Surinam.
Niemel PL, Brunings EA, Menke HE
Br J Vener Dis 1979 Apr;55(2):99-101. doi: 10.1136/sti.55.2.99. PMID: 445127Free PMC Article
CLINICAL AND PATHOLOGICAL OBSERVATIONS ON JAMAICAN NEUROPATHY; A REPORT ON 206 CASES.
MONTGOMERY RD, CRUICKSHANK EK, ROBERTSON WB, MCMENEMEY WH
Brain 1964 Sep;87:425-62. doi: 10.1093/brain/87.3.425. PMID: 14215171

Recent systematic reviews

Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.
Zhang Y, Goh SM, Mello MB, Baggaley RC, Wi T, Johnson CC, Asiedu KB, Marks M, Pham MD, Fairley CK, Chow EPF, Mitjà O, Toskin I, Ballard RC, Ong JJ
Sex Transm Infect 2022 Dec;98(8):608-616. Epub 2022 Sep 30 doi: 10.1136/sextrans-2022-055546. PMID: 36180209Free PMC Article
Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis.
Li J, Xiong T, Yue Y, Choonara I, Qazi S, Tang J, Shi J, Wang H, Qu Y, Mu D
Am J Trop Med Hyg 2022 Oct 12;107(4):904-911. Epub 2022 Aug 15 doi: 10.4269/ajtmh.22-0134. PMID: 35970284Free PMC Article
Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J
Lancet Glob Health 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890Free PMC Article
Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.
Zoni AC, Saboyá-Díaz MI, Castellanos LG, Nicholls RS, Blaya-Novakova V
PLoS Negl Trop Dis 2019 Feb;13(2):e0007125. Epub 2019 Feb 25 doi: 10.1371/journal.pntd.0007125. PMID: 30802249Free PMC Article
Global epidemiology of yaws: a systematic review.
Mitjà O, Marks M, Konan DJ, Ayelo G, Gonzalez-Beiras C, Boua B, Houinei W, Kobara Y, Tabah EN, Nsiire A, Obvala D, Taleo F, Djupuri R, Zaixing Z, Utzinger J, Vestergaard LS, Bassat Q, Asiedu K
Lancet Glob Health 2015 Jun;3(6):e324-31. doi: 10.1016/S2214-109X(15)00011-X. PMID: 26001576Free PMC Article

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