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Regional Renal Pelvis and Ureter Urothelial Carcinoma

MedGen UID:
124713
•Concept ID:
C0280281
•
Neoplastic Process
Synonyms: Regional Transitional Cell Cancer of Renal Pelvis and Ureter; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Regional Transitional Cell Carcinoma of Renal Pelvis and Ureter; Regional Upper Urinary Tract Urothelial Carcinoma; Regional Urothelial Carcinoma of the Renal Pelvis and Ureter

Definition

Urothelial carcinoma of the renal pelvis or ureter that has spread to adjacent tissues and/or regional lymph nodes but not to distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRegional Renal Pelvis and Ureter Urothelial Carcinoma

Professional guidelines

PubMed

Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218
The role of systemic chemotherapy in management of upper tract urothelial cancer.
Gayed BA, Thoreson GR, Margulis V
Curr Urol Rep 2013 Apr;14(2):94-101. doi: 10.1007/s11934-013-0307-z. PMID: 23344684
European guidelines for the diagnosis and management of upper urinary tract urothelial cell carcinomas: 2011 update.
Rouprêt M, Zigeuner R, Palou J, Boehle A, Kaasinen E, Sylvester R, Babjuk M, Oosterlinck W
Eur Urol 2011 Apr;59(4):584-94. Epub 2011 Jan 14 doi: 10.1016/j.eururo.2010.12.042. PMID: 21269756

Recent clinical studies

Etiology

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Endemic nephropathy and upper urothelial carcinoma--new insights in molecular biology.
Jankovic Velickovic L, Dolicanin Z, Stefanovic V
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014;35(1):57-64. PMID: 24802310
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Diagnosis

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Endemic nephropathy and upper urothelial carcinoma--new insights in molecular biology.
Jankovic Velickovic L, Dolicanin Z, Stefanovic V
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014;35(1):57-64. PMID: 24802310
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Therapy

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of localized high-risk disease.
Gakis G, Schubert T, Alemozaffar M, Bellmunt J, Bochner BH, Boorjian SA, Daneshmand S, Huang WC, Kondo T, Konety BR, Laguna MP, Matin SF, Siefker-Radtke AO, Shariat SF, Stenzl A
World J Urol 2017 Mar;35(3):327-335. Epub 2016 Apr 4 doi: 10.1007/s00345-016-1819-1. PMID: 27043218
The role of systemic chemotherapy in management of upper tract urothelial cancer.
Gayed BA, Thoreson GR, Margulis V
Curr Urol Rep 2013 Apr;14(2):94-101. doi: 10.1007/s11934-013-0307-z. PMID: 23344684
Cigarette smoking and cancers of the renal pelvis and ureter.
McLaughlin JK, Silverman DT, Hsing AW, Ross RK, Schoenberg JB, Yu MC, Stemhagen A, Lynch CF, Blot WJ, Fraumeni JF Jr
Cancer Res 1992 Jan 15;52(2):254-7. PMID: 1728398

Prognosis

Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Recent advances in upper tract urothelial carcinomas: From bench to clinics.
Shao IH, Chang YH, Pang ST
Int J Urol 2019 Feb;26(2):148-159. Epub 2018 Oct 29 doi: 10.1111/iju.13826. PMID: 30372791
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Small cell carcinoma of the renal pelvis and ureter: clinicopathologic and immunohistochemical features.
Miller RJ, Holmäng S, Johansson SL, Lele SM
Arch Pathol Lab Med 2011 Dec;135(12):1565-9. doi: 10.5858/arpa.2010-0690-OA. PMID: 22129185
Urinary system.
Lynch CF, Cohen MB
Cancer 1995 Jan 1;75(1 Suppl):316-29. doi: 10.1002/1097-0142(19950101)75:1+<316::aid-cncr2820751314>3.0.co;2-t. PMID: 8001003

Clinical prediction guides

Enfortumab vedotin following platinum-based chemotherapy and immune checkpoint inhibitors for advanced urothelial carcinoma: response, survival and safety analysis from a multicentre real-world Japanese cohort.
Miyake M, Nishimura N, Oda Y, Miyamoto T, Ohmori C, Takamatsu N, Itami Y, Tachibana A, Matsumoto Y, Kiba K, Tomioka A, Yamamoto H, Okajima E, Masaomi K, Sakamoto K, Tomizawa M, Shimizu T, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Torimoto K, Tanaka N, Fujimoto K; Nara Urological Research and Treatment Group
Jpn J Clin Oncol 2024 Mar 9;54(3):329-338. doi: 10.1093/jjco/hyad170. PMID: 38061911
Trends of incidence and prognosis of upper tract urothelial carcinoma.
Wu J, Chen S, Wu X, Mao W, Wang Y, Xu B, Zheng D, Chen M
Bosn J Basic Med Sci 2021 Oct 1;21(5):607-619. doi: 10.17305/bjbms.2020.5345. PMID: 33357210Free PMC Article
Pattern and risk factors of local recurrence after nephroureterectomy for upper tract urothelial carcinoma.
Li X, Cui M, Gu X, Fang D, Li H, Qin S, Yang K, Zhu T, Li X, Zhou L, Gao XS, Wang D
World J Surg Oncol 2020 May 30;18(1):114. doi: 10.1186/s12957-020-01877-w. PMID: 32473636Free PMC Article
Nephrogenic adenoma of the urinary tract: A 6-year single center experience.
Turcan D, Acikalin MF, Yilmaz E, Canaz F, Arik D
Pathol Res Pract 2017 Jul;213(7):831-835. Epub 2017 Mar 25 doi: 10.1016/j.prp.2017.03.001. PMID: 28554748
Cigarette smoking and cancers of the renal pelvis and ureter.
McLaughlin JK, Silverman DT, Hsing AW, Ross RK, Schoenberg JB, Yu MC, Stemhagen A, Lynch CF, Blot WJ, Fraumeni JF Jr
Cancer Res 1992 Jan 15;52(2):254-7. PMID: 1728398

Recent systematic reviews

Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer.
Dominguez-Escrig JL, Peyronnet B, Seisen T, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Gontero P, Lam T, MacLennan S, Mostafid H, Palou J, van Rhijn BWG, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol Focus 2019 Mar;5(2):224-241. Epub 2017 Nov 20 doi: 10.1016/j.euf.2017.09.015. PMID: 29158169

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