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Abnormal optic chiasm morphology

MedGen UID:
1368546
•Concept ID:
C4476628
•
Anatomical Abnormality
Synonym: Abnormality of optic chiasm morphology
 
HPO: HP:0025163

Definition

A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Abnormal optic chiasm morphology

Professional guidelines

PubMed

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
Rathke cleft cyst. MRI criteria for presumptive diagnosis.
Gaddikeri S, Vattoth S, Riley KO, DeHoff GW, Smith CB, Combs JT, Roberson GH
Neurosciences (Riyadh) 2013 Jul;18(3):258-63. PMID: 23887217

Recent clinical studies

Etiology

The Phenotypic Spectrum of Albinism.
Kruijt CC, de Wit GC, Bergen AA, Florijn RJ, Schalij-Delfos NE, van Genderen MM
Ophthalmology 2018 Dec;125(12):1953-1960. Epub 2018 Aug 8 doi: 10.1016/j.ophtha.2018.08.003. PMID: 30098354
Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
Abnormal lateral geniculate nucleus and optic chiasm in human albinism.
Mcketton L, Kelly KR, Schneider KA
J Comp Neurol 2014 Aug 1;522(11):2680-7. Epub 2014 Apr 12 doi: 10.1002/cne.23565. PMID: 24639208
Neuroimaging for the pediatric endocrinologist.
Delman BN, Fatterpekar GM, Law M, Naidich TP
Pediatr Endocrinol Rev 2008 Feb;5 Suppl 2:708-19. PMID: 18317442
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989

Diagnosis

Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
Non-compressive disorders of the chiasm.
Purvin VA, Kawasaki A
Curr Neurol Neurosci Rep 2014 Jul;14(7):455. doi: 10.1007/s11910-014-0455-7. PMID: 24788948
Pituitary incidentaloma.
Orija IB, Weil RJ, Hamrahian AH
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):47-68. doi: 10.1016/j.beem.2011.07.003. PMID: 22305452
Pituitary incidentalomas.
Molitch ME
Endocrinol Metab Clin North Am 1997 Dec;26(4):725-40. doi: 10.1016/s0889-8529(05)70279-6. PMID: 9429857
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Therapy

Neurofibromatosis Type 1-Associated Optic Pathway Glioma in Children: A Follow-Up of 10 Years or More.
Kinori M, Armarnik S, Listernick R, Charrow J, Zeid JL
Am J Ophthalmol 2021 Jan;221:91-96. Epub 2020 Apr 10 doi: 10.1016/j.ajo.2020.03.053. PMID: 32283094
Pituitary incidentaloma.
Orija IB, Weil RJ, Hamrahian AH
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):47-68. doi: 10.1016/j.beem.2011.07.003. PMID: 22305452
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989
Primary hypophysitis: clinical-pathological correlations.
Gutenberg A, Hans V, Puchner MJ, Kreutzer J, Brück W, Caturegli P, Buchfelder M
Eur J Endocrinol 2006 Jul;155(1):101-7. doi: 10.1530/eje.1.02183. PMID: 16793955
Neuro-ophthalmology.
Thompson HS
Arch Ophthalmol 1971 Oct;86(4):462-82. doi: 10.1001/archopht.1971.01000010464021. PMID: 4329269

Prognosis

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
The Phenotypic Spectrum of Albinism.
Kruijt CC, de Wit GC, Bergen AA, Florijn RJ, Schalij-Delfos NE, van Genderen MM
Ophthalmology 2018 Dec;125(12):1953-1960. Epub 2018 Aug 8 doi: 10.1016/j.ophtha.2018.08.003. PMID: 30098354
Congenital Achiasma.
Lecler A, Attye A, Edelson C
J Neuroophthalmol 2018 Sep;38(3):344-346. doi: 10.1097/WNO.0000000000000650. PMID: 29561327
Radiation-induced optic neuropathy.
Danesh-Meyer HV
J Clin Neurosci 2008 Feb;15(2):95-100. doi: 10.1016/j.jocn.2007.09.004. PMID: 18068989
Endocrinologic disorders and optic pathway gliomas in children with neurofibromatosis type 1.
Cnossen MH, Stam EN, Cooiman LC, Simonsz HJ, Stroink H, Oranje AP, Halley DJ, de Goede-Bolder A, Niermeijer MF, de Muinck Keizer-Schrama SM
Pediatrics 1997 Oct;100(4):667-70. doi: 10.1542/peds.100.4.667. PMID: 9310522

Clinical prediction guides

Neuro-ophthalmic evaluation and management of pituitary disease.
Wang MTM, Meyer JA, Danesh-Meyer HV
Eye (Lond) 2024 Aug;38(12):2279-2288. Epub 2024 Jul 22 doi: 10.1038/s41433-024-03187-x. PMID: 39039214Free PMC Article
The Phenotypic Spectrum of Albinism.
Kruijt CC, de Wit GC, Bergen AA, Florijn RJ, Schalij-Delfos NE, van Genderen MM
Ophthalmology 2018 Dec;125(12):1953-1960. Epub 2018 Aug 8 doi: 10.1016/j.ophtha.2018.08.003. PMID: 30098354
Mechanisms for lesion localization in neuromyelitis optica spectrum disorders.
Bradl M, Reindl M, Lassmann H
Curr Opin Neurol 2018 Jun;31(3):325-333. doi: 10.1097/WCO.0000000000000551. PMID: 29465432Free PMC Article
Pituitary incidentalomas.
Molitch ME
Endocrinol Metab Clin North Am 1997 Dec;26(4):725-40. doi: 10.1016/s0889-8529(05)70279-6. PMID: 9429857
Endocrinologic disorders and optic pathway gliomas in children with neurofibromatosis type 1.
Cnossen MH, Stam EN, Cooiman LC, Simonsz HJ, Stroink H, Oranje AP, Halley DJ, de Goede-Bolder A, Niermeijer MF, de Muinck Keizer-Schrama SM
Pediatrics 1997 Oct;100(4):667-70. doi: 10.1542/peds.100.4.667. PMID: 9310522

Recent systematic reviews

Anterior visual pathway cavernous malformations.
Tan T, Tee JW, Trost N, McKelvie P, Wang YY
J Clin Neurosci 2015 Feb;22(2):258-67. Epub 2014 Nov 11 doi: 10.1016/j.jocn.2014.07.027. PMID: 25439746

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