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Breast intracanalicular fibroadenoma

MedGen UID:: 137772
•Concept ID:: C0334496
•: Neoplastic Process

Synonyms:	Breast Intracanalicular Fibroadenoma; breast intracanalicular fibroadenoma; Intracanalicular Breast Fibroadenoma; intracanalicular breast fibroadenoma; Intracanalicular Fibroadenoma; Intracanalicular fibroadenoma; intracanalicular fibroadenoma; Intracanalicular Fibroadenoma of Breast; intracanalicular fibroadenoma of breast; Intracanalicular Fibroadenoma of the Breast; intracanalicular fibroadenoma of the breast
SNOMED CT:	Intracanalicular fibroadenoma (72905006)

Monarch Initiative:	MONDO:0002377

Definition

A morphologic variant of breast fibroadenoma without clinical significance. It is characterized by distortion and compression of the ducts by proliferating stromal cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBreast intracanalicular fibroadenoma

Phenotypic abnormality
- Abnormality of the breast
  - Abnormal breast morphology
    - Breast neoplasm
      - Breast fibroepithelial neoplasm
        Fibroadenoma of the breast
        Breast intracanalicular fibroadenoma

Recent clinical studies

Etiology

Cellular fibroepithelial lesions of the breast: A long term follow up study.

Yasir S, Nassar A, Jimenez RE, Jenkins SM, Hartmann LC, Degnim AC, Frost M, Visscher DW
Ann Diagn Pathol 2018 Aug;35:85-91. Epub 2018 Jan 10 doi: 10.1016/j.anndiagpath.2018.01.005. PMID: 30029048

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.

Pfarr N, Kriegsmann M, Sinn P, Klauschen F, Endris V, Herpel E, Muckenhuber A, Jesinghaus M, Klosterhalfen B, Penzel R, Lennerz JK, Weichert W, Stenzinger A
Genes Chromosomes Cancer 2015 Jul;54(7):444-52. Epub 2015 Apr 30 doi: 10.1002/gcc.22256. PMID: 25931199

Ultrasonic elastography features of phyllodes tumors of the breast: a clinical research.

Li LJ, Zeng H, Ou B, Luo BM, Xiao XY, Zhong WJ, Zhao XB, Zhao ZZ, Yang HY, Zhi H
PLoS One 2014;9(1):e85257. Epub 2014 Jan 15 doi: 10.1371/journal.pone.0085257. PMID: 24454830 Free PMC Article

Histopathological study of stromal smooth muscle cells in fibroadenoma of the breast.

Shimizu T, Ebihara Y, Serizawa H, Toyoda M, Hirota T
Pathol Int 1996 Jun;46(6):442-9. doi: 10.1111/j.1440-1827.1996.tb03635.x. PMID: 8869996

A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family.

Staats B, Bonk U, Wanschura S, Hanisch P, Schoenmakers EF, Van de Ven WJ, Bartnitzke S, Bullerdiek J
Breast Cancer Res Treat 1996;38(3):299-303. doi: 10.1007/BF01806149. PMID: 8739083

See all (6)

Diagnosis

"Growing fibroadenoma": Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?

Nam G, Donegan L, Gorbounov M, Hacking S, Wiggins D, Ward R, Yakirevich E, Wang Y
Ann Diagn Pathol 2023 Feb;62:152069. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152069. PMID: 36527840

Fibroepithelial tumours of the breast-a review.

Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197

Fibroadenoma in Axillary Supernumerary Breast in a 17-Year-Old Girl: Case Report.

Surd A, Mironescu A, Gocan H
J Pediatr Adolesc Gynecol 2016 Oct;29(5):e79-e81. Epub 2016 May 13 doi: 10.1016/j.jpag.2016.04.008. PMID: 27184536

Phyllodes tumors and fibroadenoma common beginning and different ending.

Oprić S, Oprić D, Gugić D, Granić M
Coll Antropol 2012 Mar;36(1):235-41. PMID: 22816226

Giant intracanalicular fibroadenoma. With report of five cases.

SMITH C Jr, PARSONS RJ, BOGART WM
Calif Med 1951 Aug;75(2):101-4. PMID: 14848732 Free PMC Article

See all (17)

Therapy

Cellular fibroepithelial lesions of the breast: A long term follow up study.

Yasir S, Nassar A, Jimenez RE, Jenkins SM, Hartmann LC, Degnim AC, Frost M, Visscher DW
Ann Diagn Pathol 2018 Aug;35:85-91. Epub 2018 Jan 10 doi: 10.1016/j.anndiagpath.2018.01.005. PMID: 30029048

A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones.

Richards SM, Pine-Twaddell ED, Ioffe OB, Bellavance EC
Int J Surg Pathol 2018 Jun;26(4):356-359. Epub 2017 Nov 23 doi: 10.1177/1066896917743011. PMID: 29169272

Fine needle aspiration cytology of fibroadenoma with multinucleated stromal giant cells. A review of cases in a six-year period.

Ng WK
Acta Cytol 2002 May-Jun;46(3):535-9. doi: 10.1159/000326873. PMID: 12040649

Infarcted myxoid fibroadenoma following fine-needle aspiration.

Vargas MP, Merino MJ
Arch Pathol Lab Med 1996 Nov;120(11):1069-71. PMID: 12049112

See all (4)

Prognosis

"Growing fibroadenoma": Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?

Nam G, Donegan L, Gorbounov M, Hacking S, Wiggins D, Ward R, Yakirevich E, Wang Y
Ann Diagn Pathol 2023 Feb;62:152069. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152069. PMID: 36527840

Fibroepithelial tumours of the breast-a review.

Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197

Cellular fibroepithelial lesions of the breast: A long term follow up study.

Yasir S, Nassar A, Jimenez RE, Jenkins SM, Hartmann LC, Degnim AC, Frost M, Visscher DW
Ann Diagn Pathol 2018 Aug;35:85-91. Epub 2018 Jan 10 doi: 10.1016/j.anndiagpath.2018.01.005. PMID: 30029048

Fibroadenoma in Axillary Supernumerary Breast in a 17-Year-Old Girl: Case Report.

Surd A, Mironescu A, Gocan H
J Pediatr Adolesc Gynecol 2016 Oct;29(5):e79-e81. Epub 2016 May 13 doi: 10.1016/j.jpag.2016.04.008. PMID: 27184536

Fibroadenoma of the supernumerary breast of the axilla.

Aughsteen AA, Almasad JK, Al-Muhtaseb MH
Saudi Med J 2000 Jun;21(6):587-9. PMID: 11500714

See all (5)

Clinical prediction guides

"Growing fibroadenoma": Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?

Nam G, Donegan L, Gorbounov M, Hacking S, Wiggins D, Ward R, Yakirevich E, Wang Y
Ann Diagn Pathol 2023 Feb;62:152069. Epub 2022 Nov 22 doi: 10.1016/j.anndiagpath.2022.152069. PMID: 36527840

Infarcted myxoid fibroadenoma following fine-needle aspiration.

Vargas MP, Merino MJ
Arch Pathol Lab Med 1996 Nov;120(11):1069-71. PMID: 12049112

Histopathological study of stromal smooth muscle cells in fibroadenoma of the breast.

Shimizu T, Ebihara Y, Serizawa H, Toyoda M, Hirota T
Pathol Int 1996 Jun;46(6):442-9. doi: 10.1111/j.1440-1827.1996.tb03635.x. PMID: 8869996

Variation in glycosaminoglycan components of breast tumors.

Takeuchi J, Sobue M, Sato E, Shamoto M, Miura K
Cancer Res 1976 Jul;36(7 PT 1):2133-9. PMID: 179697

Giant intracanalicular fibroadenoma. With report of five cases.

SMITH C Jr, PARSONS RJ, BOGART WM
Calif Med 1951 Aug;75(2):101-4. PMID: 14848732 Free PMC Article

See all (6)