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Malignant biphasic mesothelioma

MedGen UID:
137775
•Concept ID:
C0334515
•
Neoplastic Process
Synonyms: Biphasic Mesothelioma; Biphasic mesothelioma; biphasic mesothelioma; Malignant Biphasic Mesothelioma; malignant biphasic mesothelioma; malignant biphasic mesothelioma, malignant; Malignant Mixed Mesothelioma; malignant mixed mesothelioma; Mesothelioma, biphasic; Mesothelioma, biphasic, malignant; mesothelioma, biphasic, malignant; mesothelioma, biphasic, malignant (morphologic abnormality); Mixed Mesothelioma; mixed mesothelioma
SNOMED CT: Malignant biphasic mesothelioma (30383009); Biphasic mesothelioma (30383009); Mesothelioma, biphasic, malignant (30383009); Mesothelioma, biphasic (30383009)
 
Monarch Initiative: MONDO:0006109

Definition

A malignant mesothelioma characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor. [from NCI]

Professional guidelines

PubMed

Membranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas.
Hiroshima K, Wu D, Koh E, Sekine Y, Ozaki D, Yusa T, Nakazawa T, Tsuji S, Miyagi Y, Walts AE, Marchevsky AM, Husain AN, Imai K
Pathol Int 2021 Sep;71(9):604-613. Epub 2021 Jul 9 doi: 10.1111/pin.13140. PMID: 34240508Free PMC Article
Pathohistological diagnosis and differential diagnosis.
Tischoff I, Neid M, Neumann V, Tannapfel A
Recent Results Cancer Res 2011;189:57-78. doi: 10.1007/978-3-642-10862-4_5. PMID: 21479896

Recent clinical studies

Etiology

Multicystic and well-differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC).
Baratti D, Kusamura S, Nonaka D, Oliva GD, Laterza B, Deraco M
Ann Surg Oncol 2007 Oct;14(10):2790-7. Epub 2007 Jul 28 doi: 10.1245/s10434-007-9475-8. PMID: 17661150

Diagnosis

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature.
Drevinskaite M, Patasius A, Kevlicius L, Mickys U, Smailyte G
BMC Cancer 2020 Feb 27;20(1):162. doi: 10.1186/s12885-020-6648-3. PMID: 32106829Free PMC Article
Mesothelioma of the tunica vaginalis. Case report.
Busto Martin L, Portela Pereira P, Sacristan Lista F, Busto Castañon L
Arch Esp Urol 2013 May;66(4):384-8. PMID: 23676545
Primary malignant mesothelioma of the appendix.
Hayashi K, Takamura M, Sato Y, Takahashi K, Sato H, Youkou K, Yokoyama H, Nomoto M, Inoue C, Hasegawa G, Aoyagi Y
Intern Med 2012;51(9):1027-30. Epub 2012 Apr 29 doi: 10.2169/internalmedicine.51.6990. PMID: 22576381
Malignant mesothelioma arising from a benign mediastinal mesothelial cyst.
Bierhoff E, Pfeifer U
Gen Diagn Pathol 1996 Jun;142(1):59-62. PMID: 8793488

Therapy

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature.
Drevinskaite M, Patasius A, Kevlicius L, Mickys U, Smailyte G
BMC Cancer 2020 Feb 27;20(1):162. doi: 10.1186/s12885-020-6648-3. PMID: 32106829Free PMC Article
Primary malignant mesothelioma of the appendix.
Hayashi K, Takamura M, Sato Y, Takahashi K, Sato H, Youkou K, Yokoyama H, Nomoto M, Inoue C, Hasegawa G, Aoyagi Y
Intern Med 2012;51(9):1027-30. Epub 2012 Apr 29 doi: 10.2169/internalmedicine.51.6990. PMID: 22576381
Multicystic and well-differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC).
Baratti D, Kusamura S, Nonaka D, Oliva GD, Laterza B, Deraco M
Ann Surg Oncol 2007 Oct;14(10):2790-7. Epub 2007 Jul 28 doi: 10.1245/s10434-007-9475-8. PMID: 17661150

Prognosis

Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature.
Drevinskaite M, Patasius A, Kevlicius L, Mickys U, Smailyte G
BMC Cancer 2020 Feb 27;20(1):162. doi: 10.1186/s12885-020-6648-3. PMID: 32106829Free PMC Article
Primary malignant mesothelioma of the appendix.
Hayashi K, Takamura M, Sato Y, Takahashi K, Sato H, Youkou K, Yokoyama H, Nomoto M, Inoue C, Hasegawa G, Aoyagi Y
Intern Med 2012;51(9):1027-30. Epub 2012 Apr 29 doi: 10.2169/internalmedicine.51.6990. PMID: 22576381
Multicystic and well-differentiated papillary peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC).
Baratti D, Kusamura S, Nonaka D, Oliva GD, Laterza B, Deraco M
Ann Surg Oncol 2007 Oct;14(10):2790-7. Epub 2007 Jul 28 doi: 10.1245/s10434-007-9475-8. PMID: 17661150

Clinical prediction guides

Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines.
Bepler G, Koehler A, Kiefer P, Havemann K, Beisenherz K, Jaques G, Gropp C, Haeder M
Differentiation 1988;37(2):158-71. doi: 10.1111/j.1432-0436.1988.tb00806.x. PMID: 2840315

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