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Elevated vascular endothelial growth factor level

MedGen UID:
1385967
•Concept ID:
C4476933
•
Finding
Synonym: Elevated circulating VEGF concentration
 
HPO: HP:0031052

Definition

Increased blood concentration of vascular endothelial growth factor (VEGF). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated vascular endothelial growth factor level

Professional guidelines

PubMed

Chronic hypertension and superimposed preeclampsia: screening and diagnosis.
Kametas NA, Nzelu D, Nicolaides KH
Am J Obstet Gynecol 2022 Feb;226(2S):S1182-S1195. Epub 2021 Jun 17 doi: 10.1016/j.ajog.2020.11.029. PMID: 35177217
Safety of ramucirumab treatment in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein.
Yen CC, Yen CJ
Expert Opin Drug Saf 2022 Feb;21(2):157-166. Epub 2021 Oct 28 doi: 10.1080/14740338.2022.1995353. PMID: 34668832
Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.
Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DG
Gut 2022 Jan;71(1):185-193. Epub 2021 Jan 11 doi: 10.1136/gutjnl-2020-322493. PMID: 33431577Free PMC Article

Recent clinical studies

Etiology

Vascular endothelial growth factors and risk of cardio-renal events: Results from the CREDENCE trial.
Januzzi JL Jr, Liu Y, Sattar N, Yavin Y, Pollock CA, Butler J, Jardine M, Heerspink HJL, Masson S, Breyer M, Hansen MK
Am Heart J 2024 May;271:38-47. Epub 2024 Feb 22 doi: 10.1016/j.ahj.2024.02.016. PMID: 38401646
Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease.
Elahi FM, Casaletto KB, La Joie R, Walters SM, Harvey D, Wolf A, Edwards L, Rivera-Contreras W, Karydas A, Cobigo Y, Rosen HJ, DeCarli C, Miller BL, Rabinovici GD, Kramer JH
Alzheimers Dement 2020 Apr;16(4):681-695. Epub 2020 Jan 16 doi: 10.1016/j.jalz.2019.09.004. PMID: 31879236Free PMC Article
Pro-angiogenic therapeutics for preeclampsia.
Eddy AC, Bidwell GL 3rd, George EM
Biol Sex Differ 2018 Aug 25;9(1):36. doi: 10.1186/s13293-018-0195-5. PMID: 30144822Free PMC Article
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK
Nat Rev Clin Oncol 2018 May;15(5):325-340. Epub 2018 Mar 6 doi: 10.1038/nrclinonc.2018.29. PMID: 29508855Free PMC Article
Retinopathy of prematurity.
Chen J, Smith LE
Angiogenesis 2007;10(2):133-40. Epub 2007 Feb 27 doi: 10.1007/s10456-007-9066-0. PMID: 17332988

Diagnosis

Expert review: preeclampsia Type I and Type II.
Yagel S, Cohen SM, Admati I, Skarbianskis N, Solt I, Zeisel A, Beharier O, Goldman-Wohl D
Am J Obstet Gynecol MFM 2023 Dec;5(12):101203. Epub 2023 Oct 21 doi: 10.1016/j.ajogmf.2023.101203. PMID: 37871693
Level changes of serum high-sensitivity C-reactive protein and vascular endothelial growth factor in patients with St-segment elevation myocardial infarction after percutaneous coronary intervention.
Wang HG, Ji XH, Wang CC, Tian XL
J Biol Regul Homeost Agents 2021 Jul 30;35(Special Issue on Internal Medicine n.1) doi: 10.23812/21-SI1-4. PMID: 34346198
Involvement of vascular endothelial growth factor in schizophrenia.
Rampino A, Annese T, Torretta S, Tamma R, Falcone RM, Ribatti D
Neurosci Lett 2021 Aug 24;760:136093. Epub 2021 Jun 30 doi: 10.1016/j.neulet.2021.136093. PMID: 34216717
Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease.
Elahi FM, Casaletto KB, La Joie R, Walters SM, Harvey D, Wolf A, Edwards L, Rivera-Contreras W, Karydas A, Cobigo Y, Rosen HJ, DeCarli C, Miller BL, Rabinovici GD, Kramer JH
Alzheimers Dement 2020 Apr;16(4):681-695. Epub 2020 Jan 16 doi: 10.1016/j.jalz.2019.09.004. PMID: 31879236Free PMC Article
SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB.
Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD
Retina 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. PMID: 28106709Free PMC Article

Therapy

Molecular mechanism of VEGF and its role in pathological angiogenesis.
Ahmad A, Nawaz MI
J Cell Biochem 2022 Dec;123(12):1938-1965. Epub 2022 Oct 26 doi: 10.1002/jcb.30344. PMID: 36288574
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK
Nat Rev Clin Oncol 2018 May;15(5):325-340. Epub 2018 Mar 6 doi: 10.1038/nrclinonc.2018.29. PMID: 29508855Free PMC Article
SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB.
Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD
Retina 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. PMID: 28106709Free PMC Article
Ocular neovascularization.
Campochiaro PA
J Mol Med (Berl) 2013 Mar;91(3):311-21. Epub 2013 Jan 18 doi: 10.1007/s00109-013-0993-5. PMID: 23329331Free PMC Article
Neuroprotection in diabetic retinopathy.
Hernández C, Simó R
Curr Diab Rep 2012 Aug;12(4):329-37. doi: 10.1007/s11892-012-0284-5. PMID: 22581259

Prognosis

Pan-cancer analysis of homeodomain-containing gene C10 and its carcinogenesis in lung adenocarcinoma.
Tan X, Li Z, Xie H, Chen J, Xiao J, Zhi Y, Mo H, Huang Y, Liu A
Aging (Albany NY) 2023 Dec 27;15(24):15243-15266. doi: 10.18632/aging.205348. PMID: 38154103Free PMC Article
MicroRNA-1 protects the endothelium in acute lung injury.
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay MA, Pober JS, Pierce RW, Takyar SS
JCI Insight 2023 Sep 22;8(18) doi: 10.1172/jci.insight.164816. PMID: 37737266Free PMC Article
Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage.
Seki D, Mayer M, Hausmann B, Pjevac P, Giordano V, Goeral K, Unterasinger L, Klebermaß-Schrehof K, De Paepe K, Van de Wiele T, Spittler A, Kasprian G, Warth B, Berger A, Berry D, Wisgrill L
Cell Host Microbe 2021 Oct 13;29(10):1558-1572.e6. Epub 2021 Sep 3 doi: 10.1016/j.chom.2021.08.004. PMID: 34480872Free PMC Article
Involvement of vascular endothelial growth factor in schizophrenia.
Rampino A, Annese T, Torretta S, Tamma R, Falcone RM, Ribatti D
Neurosci Lett 2021 Aug 24;760:136093. Epub 2021 Jun 30 doi: 10.1016/j.neulet.2021.136093. PMID: 34216717
SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB.
Avery RL, Castellarin AA, Steinle NC, Dhoot DS, Pieramici DJ, See R, Couvillion S, Nasir MA, Rabena MD, Maia M, Van Everen S, Le K, Hanley WD
Retina 2017 Oct;37(10):1847-1858. doi: 10.1097/IAE.0000000000001493. PMID: 28106709Free PMC Article

Clinical prediction guides

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure.
Mezache L, Soltisz AM, Johnstone SR, Isakson BE, Veeraraghavan R
JACC Clin Electrophysiol 2023 Dec;9(12):2444-2458. Epub 2023 Nov 29 doi: 10.1016/j.jacep.2023.10.013. PMID: 38032579Free PMC Article
Expert review: preeclampsia Type I and Type II.
Yagel S, Cohen SM, Admati I, Skarbianskis N, Solt I, Zeisel A, Beharier O, Goldman-Wohl D
Am J Obstet Gynecol MFM 2023 Dec;5(12):101203. Epub 2023 Oct 21 doi: 10.1016/j.ajogmf.2023.101203. PMID: 37871693
Involvement of vascular endothelial growth factor in schizophrenia.
Rampino A, Annese T, Torretta S, Tamma R, Falcone RM, Ribatti D
Neurosci Lett 2021 Aug 24;760:136093. Epub 2021 Jun 30 doi: 10.1016/j.neulet.2021.136093. PMID: 34216717
Pro-angiogenic therapeutics for preeclampsia.
Eddy AC, Bidwell GL 3rd, George EM
Biol Sex Differ 2018 Aug 25;9(1):36. doi: 10.1186/s13293-018-0195-5. PMID: 30144822Free PMC Article
Peripheral vascular endothelial growth factor as a novel depression biomarker: A meta-analysis.
Carvalho AF, Köhler CA, McIntyre RS, Knöchel C, Brunoni AR, Thase ME, Quevedo J, Fernandes BS, Berk M
Psychoneuroendocrinology 2015 Dec;62:18-26. Epub 2015 Jul 8 doi: 10.1016/j.psyneuen.2015.07.002. PMID: 26210676

Recent systematic reviews

A Systematic Review of Tear Vascular Endothelial Growth Factor and External Eye Diseases.
Chan J, Lim G, Lee R, Tong L
Int J Mol Sci 2024 Jan 23;25(3) doi: 10.3390/ijms25031369. PMID: 38338647Free PMC Article
Vascular endothelial growth factor in major depressive disorder, schizophrenia, and bipolar disorder: A network meta-analysis.
Pu J, Liu Y, Gui S, Tian L, Xu S, Song X, Zhong X, Chen Y, Chen X, Yu Y, Liu L, Zhang H, Wang H, Zhou C, Zhao L, Xie P
Psychiatry Res 2020 Oct;292:113319. Epub 2020 Jul 20 doi: 10.1016/j.psychres.2020.113319. PMID: 32717712
Vascular endothelial growth factor in patients with schizophrenia: A systematic review and meta-analysis.
Misiak B, Stramecki F, Stańczykiewicz B, Frydecka D, Lubeiro A
Prog Neuropsychopharmacol Biol Psychiatry 2018 Aug 30;86:24-29. Epub 2018 May 26 doi: 10.1016/j.pnpbp.2018.05.005. PMID: 29772306
Peripheral vascular endothelial growth factor as a novel depression biomarker: A meta-analysis.
Carvalho AF, Köhler CA, McIntyre RS, Knöchel C, Brunoni AR, Thase ME, Quevedo J, Fernandes BS, Berk M
Psychoneuroendocrinology 2015 Dec;62:18-26. Epub 2015 Jul 8 doi: 10.1016/j.psyneuen.2015.07.002. PMID: 26210676
Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion.
Mitry D, Bunce C, Charteris D
Cochrane Database Syst Rev 2013 Jan 31;(1):CD009510. doi: 10.1002/14651858.CD009510.pub2. PMID: 23440840

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