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Abnormal pancreatic duct morphology

MedGen UID:
1388043
•Concept ID:
C4476900
•
Anatomical Abnormality
HPO: HP:0030992

Definition

Any structural anomaly of the pancreatic duct, which is the tubular structure that collects exocrine pancreatic secretions and transports them to the duodenum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal pancreatic duct morphology

Professional guidelines

PubMed

Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Diagnosis and treatment of pancreas divisum: A literature review.
Ferri V, Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R
Hepatobiliary Pancreat Dis Int 2019 Aug;18(4):332-336. Epub 2019 May 20 doi: 10.1016/j.hbpd.2019.05.004. PMID: 31155429
Diagnosis and treatment of pancreaticobiliary maljunction in children.
Ono S, Fumino S, Iwai N
Surg Today 2011 May;41(5):601-5. Epub 2011 May 1 doi: 10.1007/s00595-010-4492-9. PMID: 21533929

Recent clinical studies

Etiology

Mass-forming pancreatitis versus pancreatic ductal adenocarcinoma: CT and MR imaging for differentiation.
Schima W, Böhm G, Rösch CS, Klaus A, Függer R, Kopf H
Cancer Imaging 2020 Jul 23;20(1):52. doi: 10.1186/s40644-020-00324-z. PMID: 32703312Free PMC Article
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Pancreas divisum: a reemerging risk factor for pancreatic diseases.
Covantev S
Rom J Intern Med 2018 Dec 1;56(4):233-242. doi: 10.2478/rjim-2018-0022. PMID: 30521477
Chronic Pancreatitis.
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425

Diagnosis

Pancreas divisum: a reemerging risk factor for pancreatic diseases.
Covantev S
Rom J Intern Med 2018 Dec 1;56(4):233-242. doi: 10.2478/rjim-2018-0022. PMID: 30521477
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425
Idiopathic chronic pancreatitis.
Keller J, Layer P
Best Pract Res Clin Gastroenterol 2008;22(1):105-13. doi: 10.1016/j.bpg.2007.10.006. PMID: 18206816
Secretin-enhanced MR pancreatography.
Matos C, Nicaise N, Metens T, Cremer M, Devière J
Semin Ultrasound CT MR 1999 Oct;20(5):340-51. doi: 10.1016/s0887-2171(99)90065-3. PMID: 10527139
Chronic pancreatitis in the elderly.
Ammann RW
Gastroenterol Clin North Am 1990 Dec;19(4):905-14. PMID: 2269525

Therapy

The Role of Endotherapy in Recurrent Acute Pancreatitis.
Guo A, Poneros JM
Gastrointest Endosc Clin N Am 2018 Oct;28(4):455-476. Epub 2018 Aug 1 doi: 10.1016/j.giec.2018.05.001. PMID: 30241638
Pancreaticobiliary maljunction.
Kamisawa T, Takuma K, Anjiki H, Egawa N, Kurata M, Honda G, Tsuruta K, Sasaki T
Clin Gastroenterol Hepatol 2009 Nov;7(11 Suppl):S84-8. doi: 10.1016/j.cgh.2009.08.024. PMID: 19896105
Gut ischaemia.
Haglund U
Gut 1994 Jan;35(1 Suppl):S73-6. doi: 10.1136/gut.35.1_suppl.s73. PMID: 8125397Free PMC Article
Stent-guided sphincterotomy.
Siegel JH, Cohen SA, Kasmin FE, Veerappan A
Gastrointest Endosc 1994 Sep-Oct;40(5):567-72. doi: 10.1016/s0016-5107(94)70254-3. PMID: 7988820
Severe familial intrahepatic cholestasis.
Odiévre M, Gautier M, Hadchouel M, Alagille D
Arch Dis Child 1973 Oct;48(10):806-12. doi: 10.1136/adc.48.10.806. PMID: 4749685Free PMC Article

Prognosis

Mass-forming pancreatitis versus pancreatic ductal adenocarcinoma: CT and MR imaging for differentiation.
Schima W, Böhm G, Rösch CS, Klaus A, Függer R, Kopf H
Cancer Imaging 2020 Jul 23;20(1):52. doi: 10.1186/s40644-020-00324-z. PMID: 32703312Free PMC Article
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Gallbladder cancer.
Wernberg JA, Lucarelli DD
Surg Clin North Am 2014 Apr;94(2):343-60. Epub 2014 Feb 18 doi: 10.1016/j.suc.2014.01.009. PMID: 24679425
Idiopathic chronic pancreatitis.
Keller J, Layer P
Best Pract Res Clin Gastroenterol 2008;22(1):105-13. doi: 10.1016/j.bpg.2007.10.006. PMID: 18206816
Chronic pancreatitis in the elderly.
Ammann RW
Gastroenterol Clin North Am 1990 Dec;19(4):905-14. PMID: 2269525

Clinical prediction guides

Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Choledochal cysts: Similarities and differences between Asian and Western countries.
Baison GN, Bonds MM, Helton WS, Kozarek RA
World J Gastroenterol 2019 Jul 14;25(26):3334-3343. doi: 10.3748/wjg.v25.i26.3334. PMID: 31341359Free PMC Article
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction (Review).
Tsuchida A, Itoi T, Aoki T, Koyanagi Y
Oncol Rep 2003 Nov-Dec;10(6):1693-9. doi: 10.3892/or.10.6.1693. PMID: 14534681
Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings.
Sasatomi E, Tokunaga O, Miyazaki K
J Hepatobiliary Pancreat Surg 2000;7(6):556-67. doi: 10.1007/s005340070004. PMID: 11180887

Recent systematic reviews

Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature.
Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Association of mucin family members with prognostic significance in pancreatic cancer patients: A meta-analysis.
Xu W, Zhang M, Liu L, Yin M, Xu C, Weng Z
PLoS One 2022;17(6):e0269612. Epub 2022 Jun 16 doi: 10.1371/journal.pone.0269612. PMID: 35709153Free PMC Article
Clinical importance of main pancreatic duct variants and possible correlation with pancreatic diseases.
Dugic A, Nikolic S, Mühldorfer S, Bulajic M, Pozzi Mucelli R, Tsolakis AV, Löhr JM, Vujasinovic M
Scand J Gastroenterol 2020 May;55(5):517-527. Epub 2020 May 12 doi: 10.1080/00365521.2020.1760345. PMID: 32393143

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