U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acquired factor VII deficiency

MedGen UID:
1388639
•Concept ID:
C4331989
•
Disease or Syndrome
Synonyms: Acquired Factor VII Deficiency; acquired factor VII deficiency
 
Monarch Initiative: MONDO:0035738
Orphanet: ORPHA599495

Definition

An acquired coagulation disorder characterized by the partial or complete absence of factor VII activity in the blood. [from NCI]

Professional guidelines

PubMed

International recommendations on the diagnosis and treatment of acquired hemophilia A.
Tiede A, Collins P, Knoebl P, Teitel J, Kessler C, Shima M, Di Minno G, d'Oiron R, Salaj P, Jiménez-Yuste V, Huth-Kühne A, Giangrande P
Haematologica 2020 Jul;105(7):1791-1801. Epub 2020 May 7 doi: 10.3324/haematol.2019.230771. PMID: 32381574Free PMC Article
Factor VII Deficiency: From Basics to Clinical Laboratory Diagnosis and Patient Management.
Sevenet PO, Kaczor DA, Depasse F
Clin Appl Thromb Hemost 2017 Oct;23(7):703-710. Epub 2016 Oct 3 doi: 10.1177/1076029616670257. PMID: 27701084
Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment.
Zeerleder S, Levi M
Ann Med 2016;48(4):256-67. Epub 2016 Mar 26 doi: 10.3109/07853890.2016.1162909. PMID: 27018196

Recent clinical studies

Etiology

Factor VII Deficiency in Patients Receiving Chronic Packed Cell Transfusions.
Abu-Quider A, Asleh M, Fruchtman Y, Ben-Harosh M, Beck G, Abuhasira R, Kapelushnik J
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e268-e271. doi: 10.1097/MPH.0000000000001854. PMID: 32520845
Management of Labour and Delivery in a Patient With Acquired Factor VII Deficiency With Inhibitor: A Case Report.
Matei A, Dolan S, Andrews J, Rivard GÉ
J Obstet Gynaecol Can 2016 Feb;38(2):160-3. Epub 2016 Mar 2 doi: 10.1016/j.jogc.2015.11.002. PMID: 27032741
Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.
Toor AA, Slungaard A, Hedner U, Weisdorf DJ, Key NS
Bone Marrow Transplant 2002 Mar;29(5):403-8. doi: 10.1038/sj.bmt.1703381. PMID: 11919730

Diagnosis

Acquired Factor VII deficiency - a rare but important consideration.
Zaidi MH, Stanley A, Khan M
Scott Med J 2019 Aug;64(3):119-122. Epub 2019 May 29 doi: 10.1177/0036933019853167. PMID: 31142211
Acquired Factor VII Deficiency in Association with Pyelonephritis.
Anand M, Babbar N
J Assoc Physicians India 2018 May;66(5):95-6. PMID: 30477072
Isolated acquired factor VII deficiency: review of the literature.
Mulliez SM, Devreese KM
Acta Clin Belg 2016 Apr;71(2):63-70. Epub 2016 Mar 3 doi: 10.1179/2295333715Y.0000000073. PMID: 26400474
Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.
Toor AA, Slungaard A, Hedner U, Weisdorf DJ, Key NS
Bone Marrow Transplant 2002 Mar;29(5):403-8. doi: 10.1038/sj.bmt.1703381. PMID: 11919730
Acquired isolated factor VII deficiency during sepsis.
Biron C, Bengler C, Gris JC, Schved JF
Haemostasis 1997 Mar-Apr;27(2):51-6. doi: 10.1159/000217434. PMID: 9212352

Therapy

Acute Myelogenous Leukemia With Trisomy 8 and Concomitant Acquired Factor VII Deficiency.
Moosavi L, Bowen J, Coleman J, Heidari A, Cobos E
J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619872657. doi: 10.1177/2324709619872657. PMID: 31496295Free PMC Article
Isolated acquired factor VII deficiency: review of the literature.
Mulliez SM, Devreese KM
Acta Clin Belg 2016 Apr;71(2):63-70. Epub 2016 Mar 3 doi: 10.1179/2295333715Y.0000000073. PMID: 26400474
Acquired factor VII deficiency associated with acute myeloid leukemia.
Anoun S, Lamchahab M, Oukkache B, Qachouh M, Benchekroun S, Quessar A
Blood Coagul Fibrinolysis 2015 Apr;26(3):331-3. doi: 10.1097/MBC.0000000000000024. PMID: 24991944
Acquired isolated factor VII deficiency associated with severe bleeding and successful treatment with recombinant FVIIa (NovoSeven).
Mullighan CG, Rischbieth A, Duncan EM, Lloyd JV
Blood Coagul Fibrinolysis 2004 Jun;15(4):347-51. doi: 10.1097/00001721-200406000-00010. PMID: 15166922
Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.
Toor AA, Slungaard A, Hedner U, Weisdorf DJ, Key NS
Bone Marrow Transplant 2002 Mar;29(5):403-8. doi: 10.1038/sj.bmt.1703381. PMID: 11919730

Prognosis

Acquired Factor VII Deficiency Presenting with Bleeding Diathesis in a 52-Year-Old Black Man in Botswana.
Ncube M, Majaha K, Nkhori OF, Charumbira T, Mosenye SM, Shailemo D, Rwegerera GM
Clin Lab 2022 Mar 1;68(3) doi: 10.7754/Clin.Lab.2021.210702. PMID: 35254019
Factor VII Deficiency in Patients Receiving Chronic Packed Cell Transfusions.
Abu-Quider A, Asleh M, Fruchtman Y, Ben-Harosh M, Beck G, Abuhasira R, Kapelushnik J
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e268-e271. doi: 10.1097/MPH.0000000000001854. PMID: 32520845
Isolated acquired factor VII deficiency: review of the literature.
Mulliez SM, Devreese KM
Acta Clin Belg 2016 Apr;71(2):63-70. Epub 2016 Mar 3 doi: 10.1179/2295333715Y.0000000073. PMID: 26400474
Acquired factor VII deficiency associated with acute myeloid leukemia.
Anoun S, Lamchahab M, Oukkache B, Qachouh M, Benchekroun S, Quessar A
Blood Coagul Fibrinolysis 2015 Apr;26(3):331-3. doi: 10.1097/MBC.0000000000000024. PMID: 24991944
Life-threatening bleeding in a patient with a lupus inhibitor and probable acquired factor VII deficiency.
Lim S, Zuha R, Burt T, Chacko J, Scott R, Mainwaring CJ
Blood Coagul Fibrinolysis 2006 Nov;17(8):667-71. doi: 10.1097/01.mbc.0000252602.17401.7d. PMID: 17102654

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...