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Abnormal gonadotropin-releasing hormone concentration

MedGen UID:
1389720
•Concept ID:
C4477073
•
Finding
Synonyms: Abnormality of GnRH level; Abnormality of gonadotropin-releasing hormone level
 
HPO: HP:0500012

Definition

A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone (GnRH). Intermittent GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal gonadotropin-releasing hormone concentration

Professional guidelines

PubMed

Premenstrual syndrome: management and pathophysiology.
Imai A, Ichigo S, Matsunami K, Takagi H
Clin Exp Obstet Gynecol 2015;42(2):123-8. PMID: 26054102
A practical guide to the diagnosis and management of amenorrhoea.
Crosignani PG, Vegetti W
Drugs 1996 Nov;52(5):671-81. doi: 10.2165/00003495-199652050-00005. PMID: 9118817
Management of abnormal uterine bleeding.
Chuong CJ, Brenner PF
Am J Obstet Gynecol 1996 Sep;175(3 Pt 2):787-92. doi: 10.1016/s0002-9378(96)80086-x. PMID: 8828563

Recent clinical studies

Etiology

Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
Lancet Diabetes Endocrinol 2023 Aug;11(8):545-554. Epub 2023 Jun 26 doi: 10.1016/S2213-8587(23)00131-6. PMID: 37385287Free PMC Article
Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance.
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O'Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK
J Clin Endocrinol Metab 2021 Jul 13;106(8):2367-2383. doi: 10.1210/clinem/dgab275. PMID: 33901270Free PMC Article
Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls.
Chhabra S, McCartney CR, Yoo RY, Eagleson CA, Chang RJ, Marshall JC
J Clin Endocrinol Metab 2005 May;90(5):2810-5. Epub 2005 Feb 22 doi: 10.1210/jc.2004-2359. PMID: 15728200
CYP17 gene analysis in hyperandrogenised women with and without exaggerated 17-hydroxyprogesterone response to ovarian stimulation.
Liović M, Prezelj J, Kocijancic A, Majdic G, Komel R
J Endocrinol Invest 1997 Apr;20(4):189-93. doi: 10.1007/BF03346901. PMID: 9211124
LH-RH testing in men with Down's syndrome.
Horan RF, Beitins IZ, Bode HH
Acta Endocrinol (Copenh) 1978 Jul;88(3):594-600. doi: 10.1530/acta.0.0880594. PMID: 150188

Diagnosis

Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
Lancet Diabetes Endocrinol 2023 Aug;11(8):545-554. Epub 2023 Jun 26 doi: 10.1016/S2213-8587(23)00131-6. PMID: 37385287Free PMC Article
Neuroendocrine Determinants of Polycystic Ovary Syndrome.
Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, Niwczyk O, Smolarczyk R, Meczekalski B
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053089. PMID: 35270780Free PMC Article
Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls.
Chhabra S, McCartney CR, Yoo RY, Eagleson CA, Chang RJ, Marshall JC
J Clin Endocrinol Metab 2005 May;90(5):2810-5. Epub 2005 Feb 22 doi: 10.1210/jc.2004-2359. PMID: 15728200
Dysfunctional uterine bleeding.
Chen BH, Giudice LC
West J Med 1998 Nov;169(5):280-4. PMID: 9830356Free PMC Article
LH-RH testing in men with Down's syndrome.
Horan RF, Beitins IZ, Bode HH
Acta Endocrinol (Copenh) 1978 Jul;88(3):594-600. doi: 10.1530/acta.0.0880594. PMID: 150188

Therapy

Neuroendocrine Determinants of Polycystic Ovary Syndrome.
Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, Niwczyk O, Smolarczyk R, Meczekalski B
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053089. PMID: 35270780Free PMC Article
Ovarian Hyperandrogenism and Response to Gonadotropin-releasing Hormone Analogues in Primary Severe Insulin Resistance.
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O'Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK
J Clin Endocrinol Metab 2021 Jul 13;106(8):2367-2383. doi: 10.1210/clinem/dgab275. PMID: 33901270Free PMC Article
Premenstrual syndrome: management and pathophysiology.
Imai A, Ichigo S, Matsunami K, Takagi H
Clin Exp Obstet Gynecol 2015;42(2):123-8. PMID: 26054102
Resonance in the menstrual cycle: a new model of the LH surge.
Zeeman ML, Weckesser W, Gokhman D
Reprod Biomed Online 2003 Oct;7(3):295-300. doi: 10.1016/s1472-6483(10)61867-6. PMID: 14653886
Dysfunctional uterine bleeding.
Chen BH, Giudice LC
West J Med 1998 Nov;169(5):280-4. PMID: 9830356Free PMC Article

Prognosis

Re-determination of upper reference range of follicular stimulating hormone in infertile men.
Ozkaya M, Oztekin U, Caniklioglu M, Ekmekcioglu O
Syst Biol Reprod Med 2020 Oct;66(5):329-336. Epub 2020 May 22 doi: 10.1080/19396368.2020.1758834. PMID: 32441570
Dynamic tests of ovarian reserve: a systematic review of diagnostic accuracy.
Maheshwari A, Gibreel A, Bhattacharya S, Johnson NP
Reprod Biomed Online 2009 May;18(5):717-34. doi: 10.1016/s1472-6483(10)60019-3. PMID: 19549453
Resonance in the menstrual cycle: a new model of the LH surge.
Zeeman ML, Weckesser W, Gokhman D
Reprod Biomed Online 2003 Oct;7(3):295-300. doi: 10.1016/s1472-6483(10)61867-6. PMID: 14653886
Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.
Pastor CL, Griffin-Korf ML, Aloi JA, Evans WS, Marshall JC
J Clin Endocrinol Metab 1998 Feb;83(2):582-90. doi: 10.1210/jcem.83.2.4604. PMID: 9467578
Testicular function after renal transplantation.
Handelsman DJ, Ralec VL, Tiller DJ, Horvath JS, Turtle JR
Clin Endocrinol (Oxf) 1981 May;14(5):527-38. doi: 10.1111/j.1365-2265.1981.tb00642.x. PMID: 6796296

Clinical prediction guides

Neuroendocrine Determinants of Polycystic Ovary Syndrome.
Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, Niwczyk O, Smolarczyk R, Meczekalski B
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053089. PMID: 35270780Free PMC Article
Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls.
Chhabra S, McCartney CR, Yoo RY, Eagleson CA, Chang RJ, Marshall JC
J Clin Endocrinol Metab 2005 May;90(5):2810-5. Epub 2005 Feb 22 doi: 10.1210/jc.2004-2359. PMID: 15728200
Resonance in the menstrual cycle: a new model of the LH surge.
Zeeman ML, Weckesser W, Gokhman D
Reprod Biomed Online 2003 Oct;7(3):295-300. doi: 10.1016/s1472-6483(10)61867-6. PMID: 14653886
Leptin and the pituitary.
Sone M, Osamura RY
Pituitary 2001 Jan-Apr;4(1-2):15-23. doi: 10.1023/a:1012978525492. PMID: 11824504
Dysfunctional uterine bleeding.
Chen BH, Giudice LC
West J Med 1998 Nov;169(5):280-4. PMID: 9830356Free PMC Article

Recent systematic reviews

Dynamic tests of ovarian reserve: a systematic review of diagnostic accuracy.
Maheshwari A, Gibreel A, Bhattacharya S, Johnson NP
Reprod Biomed Online 2009 May;18(5):717-34. doi: 10.1016/s1472-6483(10)60019-3. PMID: 19549453
WITHDRAWN: Clomiphene or tamoxifen for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E
Cochrane Database Syst Rev 2007 Jul 18;(4):CD000151. doi: 10.1002/14651858.CD000151. PMID: 17636604
Clomiphene or tamoxifen for idiopathic oligo/asthenospermia.
Vandekerckhove P, Lilford R, Vail A, Hughes E
Cochrane Database Syst Rev 2000;1996(2):CD000151. doi: 10.1002/14651858.CD000151. PMID: 10796497Free PMC Article

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