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Headache disorder

MedGen UID:
140743
•Concept ID:
C0393735
•
Disease or Syndrome
Synonyms: Cephalgia Syndrome; Cephalgia Syndromes; Headache Disorder; Headache Disorders; Headache Syndrome; Headache Syndromes; Syndrome, Headache
SNOMED CT: Headache disorder (230461009)
 
Monarch Initiative: MONDO:0021146

Definition

Various conditions with the symptom of headache. Headache disorders are classified into major groups, such as primary headache disorders (based on characteristics of their headache symptoms) and secondary headache disorders (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1) [from MONDO]

Professional guidelines

PubMed

Diagnosis and management of migraine in ten steps.
Eigenbrodt AK, Ashina H, Khan S, Diener HC, Mitsikostas DD, Sinclair AJ, Pozo-Rosich P, Martelletti P, Ducros A, Lantéri-Minet M, Braschinsky M, Del Rio MS, Daniel O, Özge A, Mammadbayli A, Arons M, Skorobogatykh K, Romanenko V, Terwindt GM, Paemeleire K, Sacco S, Reuter U, Lampl C, Schytz HW, Katsarava Z, Steiner TJ, Ashina M
Nat Rev Neurol 2021 Aug;17(8):501-514. Epub 2021 Jun 18 doi: 10.1038/s41582-021-00509-5. PMID: 34145431Free PMC Article
Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
Acute Migraine Headache: Treatment Strategies.
Mayans L, Walling A
Am Fam Physician 2018 Feb 15;97(4):243-251. PMID: 29671521

Curated

UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

Recent clinical studies

Etiology

Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment.
Ashina H, Eigenbrodt AK, Seifert T, Sinclair AJ, Scher AI, Schytz HW, Lee MJ, De Icco R, Finkel AG, Ashina M
Lancet Neurol 2021 Jun;20(6):460-469. doi: 10.1016/S1474-4422(21)00094-6. PMID: 34022171
Cluster Headache: What's New?
Cheema S, Matharu M
Neurol India 2021 Mar-Apr;69(Supplement):S124-S134. doi: 10.4103/0028-3886.315983. PMID: 34003158
Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, Li X, Wang L, Wang L, Liu Y, Liu J, Zhang M, Qi J, Yu S, Afshin A, Gakidou E, Glenn S, Krish VS, Miller-Petrie MK, Mountjoy-Venning WC, Mullany EC, Redford SB, Liu H, Naghavi M, Hay SI, Wang L, Murray CJL, Liang X
Lancet 2019 Sep 28;394(10204):1145-1158. Epub 2019 Jun 24 doi: 10.1016/S0140-6736(19)30427-1. PMID: 31248666Free PMC Article
Headache: Tension-Type Headache.
Scripter C
FP Essent 2018 Oct;473:17-20. PMID: 30346680

Diagnosis

Medication overuse headache.
Ashina S, Terwindt GM, Steiner TJ, Lee MJ, Porreca F, Tassorelli C, Schwedt TJ, Jensen RH, Diener HC, Lipton RB
Nat Rev Dis Primers 2023 Feb 2;9(1):5. doi: 10.1038/s41572-022-00415-0. PMID: 36732518
Diagnosis and management of migraine in ten steps.
Eigenbrodt AK, Ashina H, Khan S, Diener HC, Mitsikostas DD, Sinclair AJ, Pozo-Rosich P, Martelletti P, Ducros A, Lantéri-Minet M, Braschinsky M, Del Rio MS, Daniel O, Özge A, Mammadbayli A, Arons M, Skorobogatykh K, Romanenko V, Terwindt GM, Paemeleire K, Sacco S, Reuter U, Lampl C, Schytz HW, Katsarava Z, Steiner TJ, Ashina M
Nat Rev Neurol 2021 Aug;17(8):501-514. Epub 2021 Jun 18 doi: 10.1038/s41582-021-00509-5. PMID: 34145431Free PMC Article
Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
Migraine.
Silberstein SD
Lancet 2004 Jan 31;363(9406):381-91. doi: 10.1016/S0140-6736(04)15440-8. PMID: 15070571

Therapy

The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates.
Stovner LJ, Hagen K, Linde M, Steiner TJ
J Headache Pain 2022 Apr 12;23(1):34. doi: 10.1186/s10194-022-01402-2. PMID: 35410119Free PMC Article
Post-traumatic headache attributed to traumatic brain injury: classification, clinical characteristics, and treatment.
Ashina H, Eigenbrodt AK, Seifert T, Sinclair AJ, Scher AI, Schytz HW, Lee MJ, De Icco R, Finkel AG, Ashina M
Lancet Neurol 2021 Jun;20(6):460-469. doi: 10.1016/S1474-4422(21)00094-6. PMID: 34022171
Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
Myofascial trigger points in migraine and tension-type headache.
Do TP, Heldarskard GF, Kolding LT, Hvedstrup J, Schytz HW
J Headache Pain 2018 Sep 10;19(1):84. doi: 10.1186/s10194-018-0913-8. PMID: 30203398Free PMC Article
Acute Migraine Headache: Treatment Strategies.
Mayans L, Walling A
Am Fam Physician 2018 Feb 15;97(4):243-251. PMID: 29671521

Prognosis

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Current Understanding of the Pathophysiology and Approach to Tension-Type Headache.
Steel SJ, Robertson CE, Whealy MA
Curr Neurol Neurosci Rep 2021 Oct 2;21(10):56. doi: 10.1007/s11910-021-01138-7. PMID: 34599406
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, Li X, Wang L, Wang L, Liu Y, Liu J, Zhang M, Qi J, Yu S, Afshin A, Gakidou E, Glenn S, Krish VS, Miller-Petrie MK, Mountjoy-Venning WC, Mullany EC, Redford SB, Liu H, Naghavi M, Hay SI, Wang L, Murray CJL, Liang X
Lancet 2019 Sep 28;394(10204):1145-1158. Epub 2019 Jun 24 doi: 10.1016/S0140-6736(19)30427-1. PMID: 31248666Free PMC Article
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article
Headache: Posttraumatic Headache.
Long MC
FP Essent 2018 Oct;473:26-31. PMID: 30346682

Clinical prediction guides

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.
Bi Y, Zhu Y, Tang S, Huang Y
J Headache Pain 2023 Aug 18;24(1):112. doi: 10.1186/s10194-023-01633-x. PMID: 37596566Free PMC Article
Diagnosis and Management of Headache: A Review.
Robbins MS
JAMA 2021 May 11;325(18):1874-1885. doi: 10.1001/jama.2021.1640. PMID: 33974014
The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.
Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK
Headache 2020 Jul;60(7):1300-1316. Epub 2020 May 25 doi: 10.1111/head.13836. PMID: 32449944Free PMC Article
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Zhou M, Wang H, Zeng X, Yin P, Zhu J, Chen W, Li X, Wang L, Wang L, Liu Y, Liu J, Zhang M, Qi J, Yu S, Afshin A, Gakidou E, Glenn S, Krish VS, Miller-Petrie MK, Mountjoy-Venning WC, Mullany EC, Redford SB, Liu H, Naghavi M, Hay SI, Wang L, Murray CJL, Liang X
Lancet 2019 Sep 28;394(10204):1145-1158. Epub 2019 Jun 24 doi: 10.1016/S0140-6736(19)30427-1. PMID: 31248666Free PMC Article
Red and orange flags for secondary headaches in clinical practice: SNNOOP10 list.
Do TP, Remmers A, Schytz HW, Schankin C, Nelson SE, Obermann M, Hansen JM, Sinclair AJ, Gantenbein AR, Schoonman GG
Neurology 2019 Jan 15;92(3):134-144. Epub 2018 Dec 26 doi: 10.1212/WNL.0000000000006697. PMID: 30587518Free PMC Article

Recent systematic reviews

Primary headache disorders and body mass index categories: A systematic review and dose-response meta-analysis.
Martami F, Jayedi A, Shab-Bidar S
Headache 2022 Jul;62(7):801-810. Epub 2022 Jul 19 doi: 10.1111/head.14356. PMID: 35851952
Spinal manipulation for the management of cervicogenic headache: A systematic review and meta-analysis.
Fernandez M, Moore C, Tan J, Lian D, Nguyen J, Bacon A, Christie B, Shen I, Waldie T, Simonet D, Bussières A
Eur J Pain 2020 Oct;24(9):1687-1702. Epub 2020 Jul 20 doi: 10.1002/ejp.1632. PMID: 32621321
The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.
Hindiyeh NA, Zhang N, Farrar M, Banerjee P, Lombard L, Aurora SK
Headache 2020 Jul;60(7):1300-1316. Epub 2020 May 25 doi: 10.1111/head.13836. PMID: 32449944Free PMC Article
Treatment of Cluster Headache: The American Headache Society Evidence-Based Guidelines.
Robbins MS, Starling AJ, Pringsheim TM, Becker WJ, Schwedt TJ
Headache 2016 Jul;56(7):1093-106. doi: 10.1111/head.12866. PMID: 27432623
Obesity and headache: part I--a systematic review of the epidemiology of obesity and headache.
Chai NC, Scher AI, Moghekar A, Bond DS, Peterlin BL
Headache 2014 Feb;54(2):219-34. doi: 10.1111/head.12296. PMID: 24512574Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

    Consumer resources

    Reviews

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