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Chronic renal insufficiency

MedGen UID:
140787
Concept ID:
C0403447
Disease or Syndrome
Synonyms: Chronic Kidney Insufficiencies; Chronic Kidney Insufficiency; Chronic Renal Insufficiencies; Chronic Renal Insufficiency; Kidney Insufficiencies, Chronic; Kidney Insufficiency, Chronic; Renal Insufficiencies, Chronic; Renal Insufficiency, Chronic
SNOMED CT: Chronic renal impairment (709044004); Chronic renal insufficiency (723190009)

Definition

Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic renal insufficiency

Professional guidelines

PubMed

Gossard TR, Trotti LM, Videnovic A, St Louis EK
Neurotherapeutics 2021 Jan;18(1):140-155. Epub 2021 Apr 20 doi: 10.1007/s13311-021-01019-4. PMID: 33880737Free PMC Article
Wiles K, Chappell LC, Lightstone L, Bramham K
Clin J Am Soc Nephrol 2020 Sep 7;15(9):1371-1380. Epub 2020 Apr 2 doi: 10.2215/CJN.15121219. PMID: 32241779Free PMC Article
Dubin RF, Rhee EP
Clin J Am Soc Nephrol 2020 Mar 6;15(3):404-411. Epub 2019 Oct 21 doi: 10.2215/CJN.07420619. PMID: 31636087Free PMC Article

Recent clinical studies

Etiology

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group
Kidney Int 2024 Apr;105(4S):S117-S314. doi: 10.1016/j.kint.2023.10.018. PMID: 38490803
Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group
Kidney Int 2022 Nov;102(5S):S1-S127. doi: 10.1016/j.kint.2022.06.008. PMID: 36272764
Charles C, Ferris AH
Prim Care 2020 Dec;47(4):585-595. Epub 2020 Sep 25 doi: 10.1016/j.pop.2020.08.001. PMID: 33121630
Ammirati AL
Rev Assoc Med Bras (1992) 2020 Jan 13;66Suppl 1(Suppl 1):s03-s09. doi: 10.1590/1806-9282.66.S1.3. PMID: 31939529
Drawz P, Rahman M
Ann Intern Med 2015 Jun 2;162(11):ITC1-16. doi: 10.7326/AITC201506020. PMID: 26030647

Diagnosis

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group
Kidney Int 2024 Apr;105(4S):S117-S314. doi: 10.1016/j.kint.2023.10.018. PMID: 38490803
Panzarino V, Lesser J, Cassani FA
Adv Pediatr 2022 Aug;69(1):123-132. doi: 10.1016/j.yapd.2022.03.008. PMID: 35985704
Levey AS
Nephron 2022;146(3):302-305. Epub 2021 Jun 24 doi: 10.1159/000516647. PMID: 34167119
Charles C, Ferris AH
Prim Care 2020 Dec;47(4):585-595. Epub 2020 Sep 25 doi: 10.1016/j.pop.2020.08.001. PMID: 33121630
Drawz P, Rahman M
Ann Intern Med 2015 Jun 2;162(11):ITC1-16. doi: 10.7326/AITC201506020. PMID: 26030647

Therapy

Jiang S, Fang J, Li W
Cochrane Database Syst Rev 2023 Jan 3;1(1):CD014906. doi: 10.1002/14651858.CD014906.pub2. PMID: 36594428Free PMC Article
Zheng J, Zhang Y, Rasheed H, Walker V, Sugawara Y, Li J, Leng Y, Elsworth B, Wootton RE, Fang S, Yang Q, Burgess S, Haycock PC, Borges MC, Cho Y, Carnegie R, Howell A, Robinson J, Thomas LF, Brumpton BM, Hveem K, Hallan S, Franceschini N, Morris AP, Köttgen A, Pattaro C, Wuttke M, Yamamoto M, Kashihara N, Akiyama M, Kanai M, Matsuda K, Kamatani Y, Okada Y, Walters R, Millwood IY, Chen Z, Davey Smith G, Barbour S, Yu C, Åsvold BO, Zhang H, Gaunt TR
Int J Epidemiol 2022 Jan 6;50(6):1995-2010. Epub 2021 Oct 20 doi: 10.1093/ije/dyab203. PMID: 34999880Free PMC Article
Villanego F, Naranjo J, Vigara LA, Cazorla JM, Montero ME, García T, Torrado J, Mazuecos A
Nefrologia (Engl Ed) 2020 May-Jun;40(3):237-252. Epub 2020 Apr 15 doi: 10.1016/j.nefro.2020.01.002. PMID: 32305232
Mallamaci F, Pisano A, Tripepi G
Nephrol Dial Transplant 2020 Mar 1;35(Suppl 2):ii18-ii22. doi: 10.1093/ndt/gfaa012. PMID: 32162664Free PMC Article
Zha Y, Qian Q
Nutrients 2017 Feb 27;9(3) doi: 10.3390/nu9030208. PMID: 28264439Free PMC Article

Prognosis

Wu G, Cai M, Wang C, Zou H, Wang X, Hua J, Lin H
Sci Total Environ 2023 Jul 10;881:163406. Epub 2023 Apr 11 doi: 10.1016/j.scitotenv.2023.163406. PMID: 37054795
Ye Z, An S, Gao Y, Xie E, Zhao X, Guo Z, Li Y, Shen N, Ren J, Zheng J
Eur J Med Res 2023 Jan 18;28(1):33. doi: 10.1186/s40001-023-00995-x. PMID: 36653875Free PMC Article
Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, Deng X, Xiang D, Zhu Y, Xu P, Zhai Z, Zhang D, Dai Z, Gao J
Front Endocrinol (Lausanne) 2021;12:672350. Epub 2021 Jul 1 doi: 10.3389/fendo.2021.672350. PMID: 34276558Free PMC Article
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Go AS
Semin Nephrol 2016 Jul;36(4):293-304. doi: 10.1016/j.semnephrol.2016.05.006. PMID: 27475660

Clinical prediction guides

Kroll RG, Yelavarthy P, Menees DS, Sutton NR
Interv Cardiol Clin 2020 Jul;9(3):321-333. Epub 2020 May 11 doi: 10.1016/j.iccl.2020.02.003. PMID: 32471673
Dubin RF, Rhee EP
Clin J Am Soc Nephrol 2020 Mar 6;15(3):404-411. Epub 2019 Oct 21 doi: 10.2215/CJN.07420619. PMID: 31636087Free PMC Article
Inker LA, Heerspink HJL, Tighiouart H, Levey AS, Coresh J, Gansevoort RT, Simon AL, Ying J, Beck GJ, Wanner C, Floege J, Li PK, Perkovic V, Vonesh EF, Greene T
J Am Soc Nephrol 2019 Sep;30(9):1735-1745. Epub 2019 Jul 10 doi: 10.1681/ASN.2019010007. PMID: 31292197Free PMC Article
Mihai S, Codrici E, Popescu ID, Enciu AM, Albulescu L, Necula LG, Mambet C, Anton G, Tanase C
J Immunol Res 2018;2018:2180373. Epub 2018 Sep 6 doi: 10.1155/2018/2180373. PMID: 30271792Free PMC Article
Wang S, Chen F, Yang S, Shi J
Int Heart J 2018 Jul 31;59(4):786-790. Epub 2018 Jul 18 doi: 10.1536/ihj.17-154. PMID: 30022770

Recent systematic reviews

Parker K, Hartemink J, Saha A, Mitra R, Lewis P, Power A, Choudhuri S, Mitra S, Thachil J
J Nephrol 2022 Nov;35(8):2015-2033. Epub 2022 Aug 25 doi: 10.1007/s40620-022-01413-x. PMID: 36006608Free PMC Article
Villanego F, Naranjo J, Vigara LA, Cazorla JM, Montero ME, García T, Torrado J, Mazuecos A
Nefrologia (Engl Ed) 2020 May-Jun;40(3):237-252. Epub 2020 Apr 15 doi: 10.1016/j.nefro.2020.01.002. PMID: 32305232
Sinha Ray A, Haikal A, Hammoud KA, Yu ASL
Clin J Am Soc Nephrol 2016 Dec 7;11(12):2132-2140. Epub 2016 Nov 28 doi: 10.2215/CJN.05920616. PMID: 27895134Free PMC Article
Spoto B, Pisano A, Zoccali C
Am J Physiol Renal Physiol 2016 Dec 1;311(6):F1087-F1108. Epub 2016 Oct 5 doi: 10.1152/ajprenal.00340.2016. PMID: 27707707
Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS, Hobbs FD
PLoS One 2016;11(7):e0158765. Epub 2016 Jul 6 doi: 10.1371/journal.pone.0158765. PMID: 27383068Free PMC Article

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