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Chronic brain syndrome

MedGen UID:
14213
•Concept ID:
C0006109
•
Disease or Syndrome
Synonyms: Brain Damage, Chronic; Chronic Brain Damage; Chronic Encephalopathy; Encephalopathy, Chronic
SNOMED CT: Chronic brain syndrome (78689005); Chronic encephalopathy (78689005)

Definition

Encephalopathy that is persistent or long-standing in nature. [from NCI]

Professional guidelines

PubMed

Principles of psychiatric management of chronic brain syndrome.
Plutzky M
Geriatrics 1974 Aug;29(8):120-4 passim. PMID: 4842811
ESTROGEN TREATMENT OF PATIENTS WITH CHRONIC BRAIN SYNDROME ASSOCIATED WITH CEREBRAL ARTERIOSCLEROSIS.
LEFSHITZ K, KLINE NS
Am J Psychiatry 1965 Sep;122:329-31. doi: 10.1176/ajp.122.3.329. PMID: 14327479
Meprobamatebenactyzine (deprol) in the treatment of chronic brain syndrome, schizophrenia and senility.
PENNINGTON VM
J Am Geriatr Soc 1959 Aug;7(8):656-9. doi: 10.1111/j.1532-5415.1959.tb00962.x. PMID: 13672742

Recent clinical studies

Etiology

Emission tomography in dementia.
Pakrasi S, O'Brien JT
Nucl Med Commun 2005 Mar;26(3):189-96. doi: 10.1097/00006231-200503000-00003. PMID: 15722899
Pain assessment in the elderly.
Hayes R
Br J Nurs 1995 Nov 9-22;4(20):1199-204. doi: 10.12968/bjon.1995.4.20.1199. PMID: 8696088
Contribution to the search for vigilance-indicative EEG variables. Results of a controlled, double-blind study with pyritinol in elderly patients with symptoms of mental dysfunction.
Herrmann WM, Kern U, Röhmel J
Pharmacopsychiatry 1986 Mar;19(2):75-83. doi: 10.1055/s-2007-1017159. PMID: 3517890
Sensory stimulation of elderly patients: preliminary report on the treatment of patients with chronic brain syndrome in an old age home.
Ernst P, Badash D, Beran B, Kosovsky R, Lerner K, Kleinhauz M
Isr Ann Psychiatr Relat Discip 1978 Dec;16(4):315-26. PMID: 285043
The chronic brain syndrome of infantile hydrocephalus. A follow-up study of 63 spontaneously arrested cases.
Hagberg B, Sjorgen I
Am J Dis Child 1966 Sep;112(3):189-96. doi: 10.1001/archpedi.1966.02090120057004. PMID: 5945531

Diagnosis

Pain assessment in the elderly.
Hayes R
Br J Nurs 1995 Nov 9-22;4(20):1199-204. doi: 10.12968/bjon.1995.4.20.1199. PMID: 8696088
Chronic brain syndrome reconsidered.
Rogers RC, Ferretti SM, Erdman WJ
Bol Asoc Med P R 1982 Sep;74(9):265-7. PMID: 6963916
Isolation and the symptoms of chronic brain syndrome.
Ernst P, Beran B, Safford F, Kleinhauz M
Gerontologist 1978 Oct;18(5 Pt 1):468-74. doi: 10.1093/geront/18.5_part_1.468. PMID: 400772
Functioning of the elderly patient in relation to the physician's diagnosis of chronic brain syndrome.
Carmichael J, Linn MW
J Am Geriatr Soc 1974 May;22(5):217-21. doi: 10.1111/j.1532-5415.1974.tb01942.x. PMID: 4819524
Some clinical and biochemical variables in patients with chronic brain syndrome.
Hattangadi SB, Grad B, Beckett ME, Csank JZ
J Am Geriatr Soc 1973 Oct;21(10):460-4. doi: 10.1111/j.1532-5415.1973.tb01209.x. PMID: 4729010

Therapy

Efficacy of nylidrin hydrochloride in the treatment of cognitive impairment in the elderly.
Garetz FK, Baron JJ, Barron PB, Bjork AE
J Am Geriatr Soc 1979 May;27(5):235-6. doi: 10.1111/j.1532-5415.1979.tb06039.x. PMID: 372292
Serentil for chronic brain syndrome.
Med Lett Drugs Ther 1975 Aug 1;17(16):68. PMID: 1152819
Evaluation of EEG and clinical changes associated with pavabid therapy in chronic brain syndrome.
McQuillan LM, Lopec CA, Vibal JR
Curr Ther Res Clin Exp 1974 Jan;16(1):49-58. PMID: 4203848
Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride.
Stern FH
J Am Geriatr Soc 1970 Jun;18(6):507-12. doi: 10.1111/j.1532-5415.1970.tb01337.x. PMID: 4910976
Meprobamatebenactyzine (deprol) in the treatment of chronic brain syndrome, schizophrenia and senility.
PENNINGTON VM
J Am Geriatr Soc 1959 Aug;7(8):656-9. doi: 10.1111/j.1532-5415.1959.tb00962.x. PMID: 13672742

Prognosis

Developmental and family effects of autism.
Levitas A
Pediatr Ann 1990 Jan;19(1):52-8. doi: 10.3928/0090-4481-19900101-09. PMID: 1689020
On the effects of pyritinol on functional deficits of patients with organic mental disorders.
Herrmann WM, Kern U, Röhmel J
Pharmacopsychiatry 1986 Sep;19(5):378-85. doi: 10.1055/s-2007-1017274. PMID: 3534901
Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy.
Bruhn P, Arlien-Søborg P, Gyldensted C, Christensen EL
Acta Neurol Scand 1981 Oct;64(4):259-72. PMID: 7315195
Mortality of the aged with chronic brain syndrome.
Peck A, Wolloch L, Rodstein M
J Am Geriatr Soc 1973 Jun;21(6):264-70. doi: 10.1111/j.1532-5415.1973.tb01689.x. PMID: 4710644
The chronic brain syndrome of infantile hydrocephalus. A follow-up study of 63 spontaneously arrested cases.
Hagberg B, Sjorgen I
Am J Dis Child 1966 Sep;112(3):189-96. doi: 10.1001/archpedi.1966.02090120057004. PMID: 5945531

Clinical prediction guides

On the effects of pyritinol on functional deficits of patients with organic mental disorders.
Herrmann WM, Kern U, Röhmel J
Pharmacopsychiatry 1986 Sep;19(5):378-85. doi: 10.1055/s-2007-1017274. PMID: 3534901
Contribution to the search for vigilance-indicative EEG variables. Results of a controlled, double-blind study with pyritinol in elderly patients with symptoms of mental dysfunction.
Herrmann WM, Kern U, Röhmel J
Pharmacopsychiatry 1986 Mar;19(2):75-83. doi: 10.1055/s-2007-1017159. PMID: 3517890
Continuous reaction time in patients with hepatic encephalopathy. A quantitative measure of changes in consciousness.
Elsass P, Christensen SE, Ranek L, Theilgaard A, Tygstrup N
Scand J Gastroenterol 1981 Apr;16(3):441-7. doi: 10.3109/00365528109181995. PMID: 16435490
Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy.
Bruhn P, Arlien-Søborg P, Gyldensted C, Christensen EL
Acta Neurol Scand 1981 Oct;64(4):259-72. PMID: 7315195
Mortality of the aged with chronic brain syndrome: further observations in a five-year study.
Peck A, Wolloch L, Rodstein M
J Am Geriatr Soc 1978 Apr;26(4):170-6. doi: 10.1111/j.1532-5415.1978.tb05046.x. PMID: 416066

Recent systematic reviews

Lithium Neurotoxicity Due to Second-Generation Antipsychotics Combined With Lithium: A Systematic Review.
Netto I, Phutane VH, Ravindran B
Prim Care Companion CNS Disord 2019 Jun 20;21(3) doi: 10.4088/PCC.17r02225. PMID: 31237432

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