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Ophthalmia neonatorum

MedGen UID:
14489
•Concept ID:
C0029076
•
Disease or Syndrome
Synonyms: gonococcal conjunctivitis (neonatorum); gonococcal ophthalmia neonatorum; Neonatal Conjunctivitis; Neonatal conjunctivitis; neonatal conjunctivitis; Ophthalmia Neonatorum; ophthalmia neonatorum
SNOMED CT: Ophthalmia neonatorum (34298002); Neonatal conjunctivitis (34298002)
 
Monarch Initiative: MONDO:0004854

Definition

Inflammation of the conjunctiva in a newborn due to chemical or infectious causes. Aseptic conjunctivitis is often related to the use of prophylactic medications for infectious conjunctivitis. Septic conjunctivitis is related to perinatal exposure to microorganisms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOphthalmia neonatorum

Professional guidelines

PubMed

Ophthalmia neonatorum and the role of primary care.
McKechnie DG, Snelson E
Br J Gen Pract 2020 Dec;70(701):581. Epub 2020 Nov 26 doi: 10.3399/bjgp20X713621. PMID: 33243922Free PMC Article
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Chlamydial ophthalmia neonatorum. The dilemma of diagnosis and treatment.
Harrison HR
Am J Dis Child 1985 Jun;139(6):550-1. doi: 10.1001/archpedi.1985.02140080020022. PMID: 4003356

Recent clinical studies

Etiology

Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Ophthalmia neonatorum: what kind of prophylaxis?
Zuppa AA, D'Andrea V, Catenazzi P, Scorrano A, Romagnoli C
J Matern Fetal Neonatal Med 2011 Jun;24(6):769-73. doi: 10.3109/14767058.2010.531326. PMID: 21534852
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Ocular medications in children.
Wallace DK, Steinkuller PG
Clin Pediatr (Phila) 1998 Nov;37(11):645-52. doi: 10.1177/000992289803701101. PMID: 9825207
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Diagnosis

Ophthalmia Neonatorum.
Tan AK
N Engl J Med 2019 Jan 10;380(2):e2. doi: 10.1056/NEJMicm1808613. PMID: 30625059
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum.
Chandler JW, Rapoza PA
Int Ophthalmol Clin 1990 Winter;30(1):36-8. PMID: 2404890
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Therapy

Gonococcal infection: An unresolved problem.
Barberá MJ, Serra-Pladevall J
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Aug-Sep;37(7):458-466. Epub 2019 Feb 4 doi: 10.1016/j.eimc.2018.12.008. PMID: 30732970
Gonococcal infections.
Hook EW 3rd, Holmes KK
Ann Intern Med 1985 Feb;102(2):229-43. doi: 10.7326/0003-4819-102-2-229. PMID: 3917638
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Ophthalmia neonatorum.
Friendly DS
Pediatr Clin North Am 1983 Dec;30(6):1033-42. doi: 10.1016/s0031-3955(16)34500-x. PMID: 6359042

Prognosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921
Chlamydial infections.
Blanchard TJ, Mabey DC
Br J Clin Pract 1994 Jul-Aug;48(4):201-5. PMID: 7917800
Ophthalmia neonatorum.
O'Hara MA
Pediatr Clin North Am 1993 Aug;40(4):715-25. PMID: 8345961

Clinical prediction guides

Ophthalmia Neonatorum, Helen Keller, and the Social Dimensions of Eye Disease.
Harman LE, Margo CE
Cornea 2023 Dec 1;42(12):1601-1604. Epub 2023 Jul 6 doi: 10.1097/ICO.0000000000003332. PMID: 37410593
Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology.
Amini E, Ghasemi M, Daneshjou K
Med Sci Monit 2008 Feb;14(2):CR90-96. PMID: 18227767
Diagnosis of ophthalmia neonatorum.
Winceslaus J, Goh BT, Dunlop EM, Mantell J, Woodland RM, Forsey T, Treharne JD
Br Med J (Clin Res Ed) 1987 Nov 28;295(6610):1377-9. doi: 10.1136/bmj.295.6610.1377. PMID: 3121021Free PMC Article

Recent systematic reviews

Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis.
Vallely LM, Egli-Gany D, Wand H, Pomat WS, Homer CSE, Guy R, Silver B, Rumbold AR, Kaldor JM, Vallely AJ, Low N
Sex Transm Infect 2021 Mar;97(2):104-111. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054653. PMID: 33436505Free PMC Article
Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Guirguis-Blake JM, Evans CV, Rushkin M
JAMA 2019 Jan 29;321(4):404-406. doi: 10.1001/jama.2018.17847. PMID: 30694309Free PMC Article
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381

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