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Paracoccidioidomycosis(PCM)

MedGen UID:
14601
•Concept ID:
C0030409
•
Disease or Syndrome
Synonyms: Lobo disease; Lutz-Splendore-Almeida disease; Paracoccidioidal granuloma; PCM; South american blastomycosis
SNOMED CT: Paracoccidioidal granuloma (36866003); Mucocutaneous South American blastomycosis (36866003); Mucocutaneous-lymphangitic paracoccidioidomycosis (36866003); Paracoccidioidomycosis (59925007); South American blastomycosis (59925007); Infection by Blastomyces brasiliensis (59925007); Infection by Paracoccidioides brasiliensis (59925007); Brazilian blastomycosis (59925007); Lutz-Splendore-Almeida disease (59925007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005894
Orphanet: ORPHA73260

Definition

A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, <i>Paracoccidioides brasiliensis</i>, is a fungus limited to Latin America. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParacoccidioidomycosis
Follow this link to review classifications for Paracoccidioidomycosis in Orphanet.

Professional guidelines

PubMed

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Brazilian guidelines for the clinical management of paracoccidioidomycosis.
Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, Nathan A, Valle ACFD, Bagagli E, Benard G, Ferreira MS, Teixeira MM, Silva-Vergara ML, Pereira RM, Cavalcante RS, Hahn R, Durlacher RR, Khoury Z, Camargo ZP, Moretti ML, Martinez R
Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):715-740. Epub 2017 Jul 12 doi: 10.1590/0037-8682-0230-2017. PMID: 28746570
PARACOCCIDIOIDOMYCOSIS TREATMENT.
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article

Recent clinical studies

Etiology

Paracoccidioidomycosis: Current Status and Future Trends.
Hahn RC, Hagen F, Mendes RP, Burger E, Nery AF, Siqueira NP, Guevara A, Rodrigues AM, de Camargo ZP
Clin Microbiol Rev 2022 Dec 21;35(4):e0023321. Epub 2022 Sep 8 doi: 10.1128/cmr.00233-21. PMID: 36074014Free PMC Article
Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Paracoccidioidomycosis.
Ramos-E-Silva M, Saraiva Ldo E
Dermatol Clin 2008 Apr;26(2):257-69, vii. doi: 10.1016/j.det.2007.11.005. PMID: 18346557

Diagnosis

Paracoccidioidomycosis: Current Status and Future Trends.
Hahn RC, Hagen F, Mendes RP, Burger E, Nery AF, Siqueira NP, Guevara A, Rodrigues AM, de Camargo ZP
Clin Microbiol Rev 2022 Dec 21;35(4):e0023321. Epub 2022 Sep 8 doi: 10.1128/cmr.00233-21. PMID: 36074014Free PMC Article
Re-drawing the Maps for Endemic Mycoses.
Ashraf N, Kubat RC, Poplin V, Adenis AA, Denning DW, Wright L, McCotter O, Schwartz IS, Jackson BR, Chiller T, Bahr NC
Mycopathologia 2020 Oct;185(5):843-865. Epub 2020 Feb 10 doi: 10.1007/s11046-020-00431-2. PMID: 32040709Free PMC Article
Paracoccidioidomycosis.
Marques SA
Clin Dermatol 2012 Nov-Dec;30(6):610-5. doi: 10.1016/j.clindermatol.2012.01.006. PMID: 23068148
Advances in paracoccidioidomycosis.
Ameen M, Talhari C, Talhari S
Clin Exp Dermatol 2010 Aug;35(6):576-80. Epub 2009 Oct 23 doi: 10.1111/j.1365-2230.2009.03647.x. PMID: 19874328
Paracoccidioidomycosis.
Ramos-E-Silva M, Saraiva Ldo E
Dermatol Clin 2008 Apr;26(2):257-69, vii. doi: 10.1016/j.det.2007.11.005. PMID: 18346557

Therapy

Brazilian guidelines for the clinical management of paracoccidioidomycosis.
Shikanai-Yasuda MA, Mendes RP, Colombo AL, Queiroz-Telles F, Kono ASG, Paniago AMM, Nathan A, Valle ACFD, Bagagli E, Benard G, Ferreira MS, Teixeira MM, Silva-Vergara ML, Pereira RM, Cavalcante RS, Hahn R, Durlacher RR, Khoury Z, Camargo ZP, Moretti ML, Martinez R
Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):715-740. Epub 2017 Jul 12 doi: 10.1590/0037-8682-0230-2017. PMID: 28746570
PARACOCCIDIOIDOMYCOSIS TREATMENT.
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article
Paracoccidioidomycosis.
Marques SA
Clin Dermatol 2012 Nov-Dec;30(6):610-5. doi: 10.1016/j.clindermatol.2012.01.006. PMID: 23068148
Lobomycosis.
Talhari S, Talhari C
Clin Dermatol 2012 Jul-Aug;30(4):420-4. doi: 10.1016/j.clindermatol.2011.09.014. PMID: 22682191
Paracoccidioidomycosis.
Ramos-E-Silva M, Saraiva Ldo E
Dermatol Clin 2008 Apr;26(2):257-69, vii. doi: 10.1016/j.det.2007.11.005. PMID: 18346557

Prognosis

Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology.
Thompson GR 3rd, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, Andes DR, Armstrong-James D, Ayanlowo O, Baddley JW, Barker BM, Lopes Bezerra L, Buitrago MJ, Chamani-Tabriz L, Chan JFW, Chayakulkeeree M, Cornely OA, Cunwei C, Gangneux JP, Govender NP, Hagen F, Hedayati MT, Hohl TM, Jouvion G, Kenyon C, Kibbler CC, Klimko N, Kong DCM, Krause R, Lee Lee L, Meintjes G, Miceli MH, Rath PM, Spec A, Queiroz-Telles F, Variava E, Verweij PE, Schwartz IS, Pasqualotto AC
Lancet Infect Dis 2021 Dec;21(12):e364-e374. Epub 2021 Aug 6 doi: 10.1016/S1473-3099(21)00191-2. PMID: 34364529Free PMC Article
Neglected endemic mycoses.
Queiroz-Telles F, Fahal AH, Falci DR, Caceres DH, Chiller T, Pasqualotto AC
Lancet Infect Dis 2017 Nov;17(11):e367-e377. Epub 2017 Jul 31 doi: 10.1016/S1473-3099(17)30306-7. PMID: 28774696
PARACOCCIDIOIDOMYCOSIS TREATMENT.
Shikanai-Yasuda MA
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):31-7. doi: 10.1590/S0036-46652015000700007. PMID: 26465367Free PMC Article
Lobomycosis.
Talhari S, Talhari C
Clin Dermatol 2012 Jul-Aug;30(4):420-4. doi: 10.1016/j.clindermatol.2011.09.014. PMID: 22682191
Advances in paracoccidioidomycosis.
Ameen M, Talhari C, Talhari S
Clin Exp Dermatol 2010 Aug;35(6):576-80. Epub 2009 Oct 23 doi: 10.1111/j.1365-2230.2009.03647.x. PMID: 19874328

Clinical prediction guides

Paracoccidioides and Paracoccidioidomycosis in the 21st Century.
Rodrigues AM, Hagen F, Puccia R, Hahn RC, de Camargo ZP
Mycopathologia 2023 Apr;188(1-2):129-133. Epub 2023 Jan 12 doi: 10.1007/s11046-022-00704-y. PMID: 36633737
Endemic systemic mycoses: coccidioidomycosis, histoplasmosis, paracoccidioidomycosis and blastomycosis.
Bonifaz A, Vázquez-González D, Perusquía-Ortiz AM
J Dtsch Dermatol Ges 2011 Sep;9(9):705-14; quiz 715. Epub 2011 Jul 4 doi: 10.1111/j.1610-0387.2011.07731.x. PMID: 21722309
Paracoccidioidomycosis.
Ferreira MS
Paediatr Respir Rev 2009 Dec;10(4):161-5. Epub 2009 Sep 25 doi: 10.1016/j.prrv.2009.08.001. PMID: 19879504
Neoplasia and paracoccidioidomycosis.
Shikanai-Yasuda MA, Conceição YM, Kono A, Rivitti E, Campos AF, Campos SV
Mycopathologia 2008 Apr-May;165(4-5):303-12. doi: 10.1007/s11046-007-9047-2. PMID: 18780466
Pulmonary paracoccidioidomycosis.
Restrepo A, Benard G, de Castro CC, Agudelo CA, Tobón AM
Semin Respir Crit Care Med 2008 Apr;29(2):182-97. doi: 10.1055/s-2008-1063857. PMID: 18366000

Recent systematic reviews

Endemic Systemic Mycoses in Italy: A Systematic Review of Literature and a Practical Update.
Zerbato V, Di Bella S, Pol R, D'Aleo F, Angheben A, Farina C, Conte M, Luzzaro F; Gianluigi Lombardi on behalf of the AMCLI Mycology Committee, Luzzati R, Principe L
Mycopathologia 2023 Aug;188(4):307-334. Epub 2023 Jun 9 doi: 10.1007/s11046-023-00735-z. PMID: 37294504Free PMC Article
Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging.
de Oliveira VF, Magri MMC, Levin AS, Silva GD
Mycoses 2023 Feb;66(2):168-175. Epub 2022 Sep 13 doi: 10.1111/myc.13525. PMID: 36062632
Intestinal Paracoccidioidomycosis: Case report and systematic review.
da Cruz ER, Forno AD, Pacheco SA, Bigarella LG, Ballotin VR, Salgado K, Freisbelen D, Michelin L, Soldera J
Braz J Infect Dis 2021 Jul-Aug;25(4):101605. Epub 2021 Aug 27 doi: 10.1016/j.bjid.2021.101605. PMID: 34461048Free PMC Article
Oral Paracoccidioidomycosis affecting women: A systematic review.
Costa MC, de Carvalho MM, Sperandio FF, Ribeiro Junior NV, Hanemann JAC, Pigossi SC, de Carli ML
Mycoses 2021 Feb;64(2):108-122. Epub 2020 Oct 25 doi: 10.1111/myc.13194. PMID: 33031605
Drugs for treating paracoccidioidomycosis.
Menezes VM, Soares BG, Fontes CJ
Cochrane Database Syst Rev 2006 Apr 19;2006(2):CD004967. doi: 10.1002/14651858.CD004967.pub2. PMID: 16625617Free PMC Article

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