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Benign Infratentorial Neoplasm

MedGen UID:
155591
•Concept ID:
C0751592
•
Neoplastic Process
Synonyms: Benign Infratentorial Neoplasms; Infratentorial Neoplasm, Benign; Infratentorial Neoplasms, Benign; Neoplasm, Benign Infratentorial

Definition

A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The evolving role of reirradiation in the management of recurrent brain tumors.
De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G
J Neurooncol 2023 Sep;164(2):271-286. Epub 2023 Aug 25 doi: 10.1007/s11060-023-04407-2. PMID: 37624529Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Differential diagnosis of T2 hyperintense brainstem lesions: Part 2. Diffuse lesions.
Guzmán-De-Villoria JA, Ferreiro-Argüelles C, Fernández-García P
Semin Ultrasound CT MR 2010 Jun;31(3):260-74. doi: 10.1053/j.sult.2010.03.002. PMID: 20483393

Recent clinical studies

Etiology

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Surgery for posterior fossa ependymomas in adults.
Laviv Y, Germano IM, Mahadevan A, Kasper EM
J Neurosurg Sci 2018 Feb;62(1):63-70. Epub 2017 Sep 22 doi: 10.23736/S0390-5616.17.04190-X. PMID: 28945053
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475

Diagnosis

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Improving long-term survival in diffuse intrinsic pontine glioma.
Felker J, Broniscer A
Expert Rev Neurother 2020 Jul;20(7):647-658. Epub 2020 Jun 16 doi: 10.1080/14737175.2020.1775584. PMID: 32543245
Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Intraparenchymal infratentorial ependymoma.
O'Donnell K, Tsui A, Drummond K, Gaillard F
J Clin Neurosci 2016 Feb;24:158-9. Epub 2015 Oct 23 doi: 10.1016/j.jocn.2015.08.022. PMID: 26601816
Cerebellar mutism.
Küper M, Timmann D
Brain Lang 2013 Dec;127(3):327-33. Epub 2013 Feb 9 doi: 10.1016/j.bandl.2013.01.001. PMID: 23398780

Therapy

Mechanistic insights into medulloblastoma relapse.
Peterson K, Turos-Cabal M, Salvador AD, Palomo-Caturla I, Howell AJ, Vieira ME, Greiner SM, Barnoud T, Rodriguez-Blanco J
Pharmacol Ther 2024 Aug;260:108673. Epub 2024 Jun 8 doi: 10.1016/j.pharmthera.2024.108673. PMID: 38857789Free PMC Article
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.
Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK
Cancer Cell 2022 Dec 12;40(12):1488-1502.e7. Epub 2022 Nov 10 doi: 10.1016/j.ccell.2022.10.009. PMID: 36368321
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
Management of high-risk medulloblastoma.
Bouffet E
Neurochirurgie 2021 Feb;67(1):61-68. Epub 2019 Jun 20 doi: 10.1016/j.neuchi.2019.05.007. PMID: 31229532
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066

Prognosis

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Very Long-term Survivorship in Pediatric DIPG: Case Report and Review of the Literature.
Dimentberg E, Marceau MP, Lachance A, Bergeron-Gravel S, Saikali S, Crevier L, Bourget C, Hawkins C, Jabado N, Giannakouros P, Renzi S, Larouche V
J Pediatr Hematol Oncol 2024 May 1;46(4):211-215. Epub 2024 Apr 4 doi: 10.1097/MPH.0000000000002853. PMID: 38573000
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Childhood brain tumors.
Crawford J
Pediatr Rev 2013 Feb;34(2):63-78. doi: 10.1542/pir.34-2-63. PMID: 23378614
Brainstem tumors.
Laigle-Donadey F, Doz F, Delattre JY
Handb Clin Neurol 2012;105:585-605. doi: 10.1016/B978-0-444-53502-3.00010-0. PMID: 22230520

Clinical prediction guides

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Medulloblastoma: Molecular Classification-Based Personal Therapeutics.
Archer TC, Mahoney EL, Pomeroy SL
Neurotherapeutics 2017 Apr;14(2):265-273. doi: 10.1007/s13311-017-0526-y. PMID: 28386677Free PMC Article
Adult Atypical Teratoid/Rhabdoid Tumors.
Wu WW, Bi WL, Kang YJ, Ramkissoon SH, Prasad S, Shih HA, Reardon DA, Dunn IF
World Neurosurg 2016 Jan;85:197-204. Epub 2015 Sep 4 doi: 10.1016/j.wneu.2015.08.076. PMID: 26344637
Brainstem gliomas.
Jallo GI, Biser-Rohrbaugh A, Freed D
Childs Nerv Syst 2004 Mar;20(3):143-53. Epub 2003 Dec 11 doi: 10.1007/s00381-003-0870-6. PMID: 14669023

Recent systematic reviews

Pachymeningeal disease: a systematic review and metanalysis.
Gutiérrez-Valencia E, Sánchez I, Valles A, Díaz O, F González T, Balderrama R, Fuentes J, Ruiz V, Rodríguez J, Saavedra C, Velázquez-Pulido L, Cadavid E, E Ayala-Hernández L, Villalvazo A, H Bayardo L, Jamora K, Kalyvas A, Yang K, Millar BA, B Shultz D
J Neurooncol 2023 Oct;165(1):29-39. Epub 2023 Oct 10 doi: 10.1007/s11060-023-04476-3. PMID: 37815737
Supratentorial Hemangioblastoma in Adults: A Systematic Review and Comparison of Infratentorial and Spinal Cord Locations.
Jankovic D, Vuong K, Splavski B, Rotim K, Arnautovic KI
World Neurosurg 2023 May;173:48-62. Epub 2023 Feb 22 doi: 10.1016/j.wneu.2023.02.071. PMID: 36822402
Recurrent pediatric infratentorial ependymomas: a systematic review and meta-analysis on outcomes and molecular classification.
Montgomery EY, Thirunavu V, Pagadala M, Shlobin NA, Plant-Fox AS, Lam S, DeCuypere M
J Neurosurg Pediatr 2023 Feb 1;31(2):132-142. Epub 2022 Nov 25 doi: 10.3171/2022.10.PEDS22154. PMID: 36433871
Gamma Knife radiosurgery as primary treatment of low-grade brainstem gliomas: A systematic review and metanalysis of current evidence and predictive factors.
Gagliardi F, De Domenico P, Snider S, Pompeo E, Roncelli F, Barzaghi LR, Bailo M, Piloni M, Spina A, Fodor A, Berzero G, Di Muzio N, Filippi M, Finocchiaro G, Mortini P
Crit Rev Oncol Hematol 2021 Dec;168:103508. Epub 2021 Oct 19 doi: 10.1016/j.critrevonc.2021.103508. PMID: 34678323
Executive dysfunction in pediatric posterior fossa tumor survivors: a systematic literature review of neurocognitive deficits and interventions.
Wolfe KR, Madan-Swain A, Kana RK
Dev Neuropsychol 2012;37(2):153-75. doi: 10.1080/87565641.2011.632462. PMID: 22339228Free PMC Article

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