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Audiogenic seizures

MedGen UID:
155927
•Concept ID:
C0751791
•
Disease or Syndrome
Synonyms: Audiogenic Epilepsies; Audiogenic Epilepsy; Audiogenic Reflex Epilepsies; Audiogenic Reflex Epilepsy; Epilepsies, Audiogenic Reflex; Epilepsy, Audiogenic; Epilepsy, Audiogenic Reflex; Reflex Epilepsies, Audiogenic; Reflex Epilepsy, Audiogenic
SNOMED CT: Audiogenic epilepsy (765216006); Audiogenic seizures (765216006)
 
Monarch Initiative: MONDO:0015644
Orphanet: ORPHA166415

Definition

A rare neurologic disease with characteristics of seizures that are triggered by acoustic stimulation, which can be simple (as in startle epilepsy) or complex (for example musicogenic seizures, seizures triggered by the voice). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAudiogenic seizures
Follow this link to review classifications for Audiogenic seizures in Orphanet.

Professional guidelines

PubMed

Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L
J Feline Med Surg 2017 Feb;19(2):200-206. Epub 2016 Jul 9 doi: 10.1177/1098612X15622806. PMID: 26690830Free PMC Article
Genetic factors in neurotoxicology and neuropharmacology: a critical evaluation of the use of genetics as a research tool.
Festing MF
Experientia 1991 Oct 15;47(10):990-8. doi: 10.1007/BF01923334. PMID: 1936208

Recent clinical studies

Etiology

ADGRV1 is implicated in myoclonic epilepsy.
Myers KA, Nasioulas S, Boys A, McMahon JM, Slater H, Lockhart P, Sart DD, Scheffer IE
Epilepsia 2018 Feb;59(2):381-388. Epub 2017 Dec 20 doi: 10.1111/epi.13980. PMID: 29266188
Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L
J Feline Med Surg 2017 Feb;19(2):200-206. Epub 2016 Jul 9 doi: 10.1177/1098612X15622806. PMID: 26690830Free PMC Article
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy.
Gürses C, Alpay K, Ciftçi FD, Bebek N, Baykan B, Gökyiğit A
Seizure 2008 Oct;17(7):625-30. doi: 10.1016/j.seizure.2008.04.003. PMID: 18486495
Intractable reflex audiogenic seizures in Aicardi syndrome.
Grosso S, Farnetani MA, Bernardoni E, Morgese G, Balestri P
Brain Dev 2007 May;29(4):243-6. Epub 2006 Nov 7 doi: 10.1016/j.braindev.2006.09.005. PMID: 17084998
Effect of ethanol and ethanol withdrawal on 3H-muscimol binding and behaviour in the rat: a pilot study.
Linnoila M, Stowell L, Marangos PJ, Thurman RG
Acta Pharmacol Toxicol (Copenh) 1981 Nov;49(5):407-11. doi: 10.1111/j.1600-0773.1981.tb00923.x. PMID: 6285669

Diagnosis

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A
JCI Insight 2021 Jan 11;6(1) doi: 10.1172/jci.insight.143251. PMID: 33232300Free PMC Article
Reflex epileptic mechanisms in humans: Lessons about natural ictogenesis.
Wolf P
Epilepsy Behav 2017 Jun;71(Pt B):118-123. Epub 2015 May 6 doi: 10.1016/j.yebeh.2015.01.009. PMID: 25958226
The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].
Sarkisova K, van Luijtelaar G
Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1;35(4):854-76. Epub 2010 Nov 17 doi: 10.1016/j.pnpbp.2010.11.010. PMID: 21093520
Ethanol and neurotransmitter interactions--from molecular to integrative effects.
Faingold CL, N'Gouemo P, Riaz A
Prog Neurobiol 1998 Aug;55(5):509-35. doi: 10.1016/s0301-0082(98)00027-6. PMID: 9670216
Genetic factors in drug neuroteratogenicity.
Yanai J
Subst Alcohol Actions Misuse 1983;4(1):19-30. PMID: 6353625

Therapy

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A
JCI Insight 2021 Jan 11;6(1) doi: 10.1172/jci.insight.143251. PMID: 33232300Free PMC Article
The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: History and perspectives.
Garcia-Cairasco N, Umeoka EHL, Cortes de Oliveira JA
Epilepsy Behav 2017 Jun;71(Pt B):250-273. Epub 2017 May 11 doi: 10.1016/j.yebeh.2017.04.001. PMID: 28506440
Abnormalities of serotonergic neurotransmission in animal models of SUDEP.
Feng HJ, Faingold CL
Epilepsy Behav 2017 Jun;71(Pt B):174-180. Epub 2015 Aug 10 doi: 10.1016/j.yebeh.2015.06.008. PMID: 26272185Free PMC Article
The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65years.
Poletaeva II, Surina NM, Kostina ZA, Perepelkina OV, Fedotova IB
Epilepsy Behav 2017 Jun;71(Pt B):130-141. Epub 2015 Jul 28 doi: 10.1016/j.yebeh.2015.04.072. PMID: 26228091
Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features.
Vinogradova LV
Epilepsy Behav 2017 Jun;71(Pt B):142-153. Epub 2015 Jul 3 doi: 10.1016/j.yebeh.2015.06.014. PMID: 26148984

Prognosis

Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study.
Lowrie M, Thomson S, Bessant C, Sparkes A, Harvey RJ, Garosi L
J Feline Med Surg 2017 Feb;19(2):200-206. Epub 2016 Jul 9 doi: 10.1177/1098612X15622806. PMID: 26690830Free PMC Article
The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].
Sarkisova K, van Luijtelaar G
Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1;35(4):854-76. Epub 2010 Nov 17 doi: 10.1016/j.pnpbp.2010.11.010. PMID: 21093520
Physiologically based pharmacokinetic/pharmacodynamic animal-to-man prediction of therapeutic dose in a model of epilepsy.
Brochot A, Zamacona M, Stockis A
Basic Clin Pharmacol Toxicol 2010 Mar;106(3):256-62. Epub 2010 Jan 25 doi: 10.1111/j.1742-7843.2009.00536.x. PMID: 20102365
The efficacy and tolerability of Levetiracetam as an add-on therapy in patients with startle epilepsy.
Gürses C, Alpay K, Ciftçi FD, Bebek N, Baykan B, Gökyiğit A
Seizure 2008 Oct;17(7):625-30. doi: 10.1016/j.seizure.2008.04.003. PMID: 18486495
Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action.
Faingold CL
Prog Neurobiol 2004 Jan;72(1):55-85. doi: 10.1016/j.pneurobio.2003.11.003. PMID: 15019176

Clinical prediction guides

Abnormalities of serotonergic neurotransmission in animal models of SUDEP.
Feng HJ, Faingold CL
Epilepsy Behav 2017 Jun;71(Pt B):174-180. Epub 2015 Aug 10 doi: 10.1016/j.yebeh.2015.06.008. PMID: 26272185Free PMC Article
Atypical antipsychotic drugs and ethanol withdrawal syndrome: a review.
Uzbay TI
Alcohol Alcohol 2012 Jan-Feb;47(1):33-41. Epub 2011 Oct 21 doi: 10.1093/alcalc/agr142. PMID: 22021556
The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depression [corrected].
Sarkisova K, van Luijtelaar G
Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 1;35(4):854-76. Epub 2010 Nov 17 doi: 10.1016/j.pnpbp.2010.11.010. PMID: 21093520
Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.
Uzbay IT
Alcohol Alcohol 2008 Jan-Feb;43(1):15-24. Epub 2007 Oct 12 doi: 10.1093/alcalc/agm145. PMID: 17934195
Ethanol and neurotransmitter interactions--from molecular to integrative effects.
Faingold CL, N'Gouemo P, Riaz A
Prog Neurobiol 1998 Aug;55(5):509-35. doi: 10.1016/s0301-0082(98)00027-6. PMID: 9670216

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