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Hypoxic Ischemic Encephalopathy

MedGen UID:
156258
•Concept ID:
C0752304
•
Disease or Syndrome
Synonyms: Encephalopathies, Hypoxic-Ischemic; Encephalopathies, Ischemic-Hypoxic; Encephalopathy, Hypoxic Ischemic; Encephalopathy, Hypoxic-Ischemic; Encephalopathy, Ischemic-Hypoxic; Hypoxic-Ischemic Encephalopathies; Hypoxic-Ischemic Encephalopathy; Ischemic Hypoxic Encephalopathy; Ischemic-Hypoxic Encephalopathies; Ischemic-Hypoxic Encephalopathy
SNOMED CT: Hypoxic ischemic encephalopathy (703300001); Hypoxic ischemic brain injury (703300001)

Definition

Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Hypoxic Ischemic Encephalopathy

Professional guidelines

PubMed

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment.
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
Diagnosis, treatment, and prevention of cerebral palsy.
O'Shea TM
Clin Obstet Gynecol 2008 Dec;51(4):816-28. doi: 10.1097/GRF.0b013e3181870ba7. PMID: 18981805Free PMC Article

Recent clinical studies

Etiology

Hypoxic Ischemic Encephalopathy (HIE) in Term and Preterm Infants.
Ristovska S, Stomnaroska O, Danilovski D
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2022 Apr 22;43(1):77-84. doi: 10.2478/prilozi-2022-0013. PMID: 35451288
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment.
Yıldız EP, Ekici B, Tatlı B
Expert Rev Neurother 2017 May;17(5):449-459. Epub 2016 Nov 23 doi: 10.1080/14737175.2017.1259567. PMID: 27830959
Erythropoietin and Neonatal Neuroprotection.
Juul SE, Pet GC
Clin Perinatol 2015 Sep;42(3):469-81. Epub 2015 May 14 doi: 10.1016/j.clp.2015.04.004. PMID: 26250911Free PMC Article

Diagnosis

Hypoxic Ischemic Encephalopathy (HIE) in Term and Preterm Infants.
Ristovska S, Stomnaroska O, Danilovski D
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2022 Apr 22;43(1):77-84. doi: 10.2478/prilozi-2022-0013. PMID: 35451288
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Neonatal Encephalopathy: Beyond Hypoxic-Ischemic Encephalopathy.
Russ JB, Simmons R, Glass HC
Neoreviews 2021 Mar;22(3):e148-e162. doi: 10.1542/neo.22-3-e148. PMID: 33649088
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Hypoxic-ischemic encephalopathy: a review for the clinician.
Douglas-Escobar M, Weiss MD
JAMA Pediatr 2015 Apr;169(4):397-403. doi: 10.1001/jamapediatrics.2014.3269. PMID: 25685948

Therapy

The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Neonatal encephalopathy and hypoxic-ischemic encephalopathy.
Gunn AJ, Thoresen M
Handb Clin Neurol 2019;162:217-237. doi: 10.1016/B978-0-444-64029-1.00010-2. PMID: 31324312
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy.
Wassink G, Davidson JO, Dhillon SK, Zhou K, Bennet L, Thoresen M, Gunn AJ
Curr Neurol Neurosci Rep 2019 Jan 14;19(2):2. doi: 10.1007/s11910-019-0916-0. PMID: 30637551
Hypothermia therapy for newborns with hypoxic ischemic encephalopathy.
Silveira RC, Procianoy RS
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S78-83. Epub 2015 Sep 4 doi: 10.1016/j.jped.2015.07.004. PMID: 26354871
Hypoxic-ischemic encephalopathy: a review for the clinician.
Douglas-Escobar M, Weiss MD
JAMA Pediatr 2015 Apr;169(4):397-403. doi: 10.1001/jamapediatrics.2014.3269. PMID: 25685948

Prognosis

Biomarkers of hypoxic-ischemic encephalopathy: a systematic review.
Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Outcome and prognostication after cardiac arrest.
Henson T, Rawanduzy C, Salazar M, Sebastian A, Weber H, Al-Mufti F, Mayer SA
Ann N Y Acad Sci 2022 Feb;1508(1):23-34. Epub 2021 Sep 27 doi: 10.1111/nyas.14699. PMID: 34580886
The Term Newborn: Evaluation for Hypoxic-Ischemic Encephalopathy.
Bonifacio SL, Hutson S
Clin Perinatol 2021 Aug;48(3):681-695. doi: 10.1016/j.clp.2021.05.014. PMID: 34353587
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH; National Institute of Child Health and Human Development Neonatal Research Network
N Engl J Med 2005 Oct 13;353(15):1574-84. doi: 10.1056/NEJMcps050929. PMID: 16221780

Clinical prediction guides

How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy?
Wu YW, Monsell SE, Glass HC, Wisnowski JL, Mathur AM, McKinstry RC, Bluml S, Gonzalez FF, Comstock BA, Heagerty PJ, Juul SE
Pediatr Res 2023 Sep;94(3):1018-1025. Epub 2023 Mar 1 doi: 10.1038/s41390-023-02510-8. PMID: 36859442Free PMC Article
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.
Finder M, Boylan GB, Twomey D, Ahearne C, Murray DM, Hallberg B
JAMA Pediatr 2020 Jan 1;174(1):48-55. doi: 10.1001/jamapediatrics.2019.4011. PMID: 31710357Free PMC Article
Neurology of cardiopulmonary resuscitation.
Mulder M, Geocadin RG
Handb Clin Neurol 2017;141:593-617. doi: 10.1016/B978-0-444-63599-0.00032-6. PMID: 28190437
Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE).
Natarajan G, Pappas A, Shankaran S
Semin Perinatol 2016 Dec;40(8):549-555. Epub 2016 Nov 15 doi: 10.1053/j.semperi.2016.09.007. PMID: 27863707Free PMC Article

Recent systematic reviews

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.
Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Biomarkers of hypoxic-ischemic encephalopathy: a systematic review.
Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Advances in Neonatal Acute Kidney Injury.
Starr MC, Charlton JR, Guillet R, Reidy K, Tipple TE, Jetton JG, Kent AL, Abitbol CL, Ambalavanan N, Mhanna MJ, Askenazi DJ, Selewski DT, Harer MW; Neonatal Kidney Collaborative Board
Pediatrics 2021 Nov;148(5) Epub 2021 Oct 1 doi: 10.1542/peds.2021-051220. PMID: 34599008
Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review.
Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M
Metab Brain Dis 2021 Dec;36(8):2195-2203. Epub 2021 Aug 17 doi: 10.1007/s11011-021-00798-1. PMID: 34403026Free PMC Article
Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.
Andersen M, Andelius TCK, Pedersen MV, Kyng KJ, Henriksen TB
BMC Pediatr 2019 Jul 19;19(1):242. doi: 10.1186/s12887-019-1603-7. PMID: 31324176Free PMC Article

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