U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast Carcinoma Metastatic in the Central Nervous System

MedGen UID:
1612003
•Concept ID:
C4524681
•
Neoplastic Process
Synonym: Breast Carcinoma Metastatic in the CNS

Definition

A carcinoma that has spread to the central nervous system from its original site in the breast, through the hematogenous route. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Central Nervous System

Professional guidelines

PubMed

Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors.
Lange M, Joly F, Vardy J, Ahles T, Dubois M, Tron L, Winocur G, De Ruiter MB, Castel H
Ann Oncol 2019 Dec 1;30(12):1925-1940. doi: 10.1093/annonc/mdz410. PMID: 31617564Free PMC Article
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR
Pharmacol Res 2018 Jun;132:47-68. Epub 2018 Mar 28 doi: 10.1016/j.phrs.2018.03.021. PMID: 29604436Free PMC Article

Recent clinical studies

Etiology

Implementing antibody-drug conjugates (ADCs) in HER2-positive breast cancer: state of the art and future directions.
Ferraro E, Drago JZ, Modi S
Breast Cancer Res 2021 Aug 11;23(1):84. doi: 10.1186/s13058-021-01459-y. PMID: 34380530Free PMC Article
ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases.
Kumthekar P, Tang SC, Brenner AJ, Kesari S, Piccioni DE, Anders C, Carrillo J, Chalasani P, Kabos P, Puhalla S, Tkaczuk K, Garcia AA, Ahluwalia MS, Wefel JS, Lakhani N, Ibrahim N
Clin Cancer Res 2020 Jun 15;26(12):2789-2799. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3258. PMID: 31969331
Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors.
Lange M, Joly F, Vardy J, Ahles T, Dubois M, Tron L, Winocur G, De Ruiter MB, Castel H
Ann Oncol 2019 Dec 1;30(12):1925-1940. doi: 10.1093/annonc/mdz410. PMID: 31617564Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Brain metastases.
Ewend MG, Carey LA, Morris DE, Harvey RD, Hensing TA
Curr Treat Options Oncol 2001 Dec;2(6):537-47. doi: 10.1007/s11864-001-0075-8. PMID: 12057099

Diagnosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Brain malignancies: Glioblastoma and brain metastases.
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR
Pharmacol Res 2018 Jun;132:47-68. Epub 2018 Mar 28 doi: 10.1016/j.phrs.2018.03.021. PMID: 29604436Free PMC Article
Leptomeningeal Metastases.
Graber JJ, Kesari S
Curr Treat Options Oncol 2018 Jan 23;19(1):3. doi: 10.1007/s11864-018-0518-0. PMID: 29362920

Therapy

Systematic characterization of antibody-drug conjugate targets in central nervous system tumors.
Coy S, Lee JS, Chan SJ, Woo T, Jones J, Alexandrescu S, Wen PY, Sorger PK, Ligon KL, Santagata S
Neuro Oncol 2024 Mar 4;26(3):458-472. doi: 10.1093/neuonc/noad205. PMID: 37870091Free PMC Article
Targeting brain metastases in breast cancer.
Corti C, Antonarelli G, Criscitiello C, Lin NU, Carey LA, Cortés J, Poortmans P, Curigliano G
Cancer Treat Rev 2022 Feb;103:102324. Epub 2021 Dec 16 doi: 10.1016/j.ctrv.2021.102324. PMID: 34953200
Implementing antibody-drug conjugates (ADCs) in HER2-positive breast cancer: state of the art and future directions.
Ferraro E, Drago JZ, Modi S
Breast Cancer Res 2021 Aug 11;23(1):84. doi: 10.1186/s13058-021-01459-y. PMID: 34380530Free PMC Article
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR
Pharmacol Res 2018 Jun;132:47-68. Epub 2018 Mar 28 doi: 10.1016/j.phrs.2018.03.021. PMID: 29604436Free PMC Article
Brain metastases.
Ewend MG, Carey LA, Morris DE, Harvey RD, Hensing TA
Curr Treat Options Oncol 2001 Dec;2(6):537-47. doi: 10.1007/s11864-001-0075-8. PMID: 12057099

Prognosis

Leptomeningeal Metastasis: A Review of the Pathophysiology, Diagnostic Methodology, and Therapeutic Landscape.
Nguyen A, Nguyen A, Dada OT, Desai PD, Ricci JC, Godbole NB, Pierre K, Lucke-Wold B
Curr Oncol 2023 Jun 19;30(6):5906-5931. doi: 10.3390/curroncol30060442. PMID: 37366925Free PMC Article
Targeting brain metastases in breast cancer.
Corti C, Antonarelli G, Criscitiello C, Lin NU, Carey LA, Cortés J, Poortmans P, Curigliano G
Cancer Treat Rev 2022 Feb;103:102324. Epub 2021 Dec 16 doi: 10.1016/j.ctrv.2021.102324. PMID: 34953200
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR
Pharmacol Res 2018 Jun;132:47-68. Epub 2018 Mar 28 doi: 10.1016/j.phrs.2018.03.021. PMID: 29604436Free PMC Article
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article

Clinical prediction guides

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment.
Song Q, Ruiz J, Xing F, Lo HW, Craddock L, Pullikuth AK, Miller LD, Soike MH, O'Neill SS, Watabe K, Chan MD, Su J
Commun Biol 2023 Jul 21;6(1):760. doi: 10.1038/s42003-023-05124-2. PMID: 37479733Free PMC Article
Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.
Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D
Nat Cell Biol 2019 Nov;21(11):1403-1412. Epub 2019 Nov 4 doi: 10.1038/s41556-019-0404-4. PMID: 31685984Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article

Recent systematic reviews

A Systematic Review of Peripheral Neuropathies in Breast Cancer-Related Lymphedema.
Forte AJ, Huayllani MT, Boczar D, Manrique OJ, Lu X, McLaughlin SA, Kung TA
Hand (N Y) 2022 Jul;17(4):668-675. Epub 2020 Oct 19 doi: 10.1177/1558944720963944. PMID: 33073616Free PMC Article
Receptor Conversion in Distant Breast Cancer Metastases: A Systematic Review and Meta-analysis.
Schrijver WAME, Suijkerbuijk KPM, van Gils CH, van der Wall E, Moelans CB, van Diest PJ
J Natl Cancer Inst 2018 Jun 1;110(6):568-580. doi: 10.1093/jnci/djx273. PMID: 29315431
Leptomeningeal metastasis in breast cancer - a systematic review.
Scott BJ, Oberheim-Bush NA, Kesari S
Oncotarget 2016 Jan 26;7(4):3740-7. doi: 10.18632/oncotarget.5911. PMID: 26543235Free PMC Article
Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis.
He W, Chen F, Dalm B, Kirby PA, Greenlee JD
Pituitary 2015 Feb;18(1):159-68. doi: 10.1007/s11102-014-0552-2. PMID: 24445565
Trastuzumab-containing regimens for metastatic breast cancer.
Balduzzi S, Mantarro S, Guarneri V, Tagliabue L, Pistotti V, Moja L, D'Amico R
Cochrane Database Syst Rev 2014 Jun 12;2014(6):CD006242. doi: 10.1002/14651858.CD006242.pub2. PMID: 24919460Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...