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Eyelid sebaceous gland carcinoma

MedGen UID:
1612781
•Concept ID:
C4525405
•
Neoplastic Process
Synonyms: carcinoma of sebaceous gland of eyelid; Eyelid Sebaceous Gland Carcinoma; eyelid sebaceous gland carcinoma; Eyelid SGC; eyelid SGC; Sebaceous Gland Carcinoma of the Eyelid; sebaceous gland carcinoma of the eyelid; sebaceous gland of eyelid carcinoma
 
Monarch Initiative: MONDO:0021588

Definition

A sebaceous gland carcinoma affecting the eyelid. It arises from the meibomian glands, glands of Zeis, or glands associated with the caruncle. It usually affects elderly women and is characterized by high rate of local recurrence, regional, and distant metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid sebaceous gland carcinoma

Professional guidelines

PubMed

Second primary tumors in retinoblastoma survivors: a study of 7 Asian Indian patients.
Kaliki S, Palkonda VAR
Int Ophthalmol 2020 Dec;40(12):3303-3308. Epub 2020 Jul 31 doi: 10.1007/s10792-020-01517-y. PMID: 32737729
Neoadjuvant Systemic Chemotherapy in the Management of Extensive Eyelid Sebaceous Gland Carcinoma: A study of 10 Cases.
Kaliki S, Ayyar A, Nair AG, Mishra DK, Reddy VA, Naik MN
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):35-9. doi: 10.1097/IOP.0000000000000398. PMID: 25675161

Recent clinical studies

Etiology

Molecular landscape of eyelid sebaceous gland carcinoma: A comprehensive review.
Jayaraj P, Ray D, Goel K, Singh A, Kant N, Sen S
Indian J Ophthalmol 2024 Oct 1;72(10):1393-1403. Epub 2024 Sep 27 doi: 10.4103/IJO.IJO_167_24. PMID: 39331429Free PMC Article
Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study.
Yang MK, Kim N, Choung H, Kim JE, Khwarg SI
BMC Ophthalmol 2023 Sep 26;23(1):390. doi: 10.1186/s12886-023-03131-9. PMID: 37752463Free PMC Article
Development and validation of a nomogram to predict the recurrence of eyelid sebaceous gland carcinoma.
Nie Z, Geng J, Xu X, Zhang R, Li D
Cancer Med 2023 Jul;12(14):14912-14921. Epub 2023 Jun 30 doi: 10.1002/cam4.6126. PMID: 37387455Free PMC Article
Eyelid sebaceous gland carcinoma, validation of AJCC 8th edition T staging- a retrospective study from North India.
Sen S, Bhardwaj M, Jayaraj P, Bakhshi S, Pushker N, Kashyap S, Bajaj MS, Khandpur S
Acta Ophthalmol 2023 Feb;101(1):49-56. Epub 2022 Jun 24 doi: 10.1111/aos.15204. PMID: 35751173
Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians.
Kaliki S, Ayyar A, Dave TV, Ali MJ, Mishra DK, Naik MN
Eye (Lond) 2015 Jul;29(7):958-63. Epub 2015 May 22 doi: 10.1038/eye.2015.79. PMID: 25998946Free PMC Article

Diagnosis

Masqueraded sebaceous gland carcinoma of the lower eyelid in a young pregnant patient.
Randelovic K, Petric Vickovic I, Lacmanovic Loncar V, Pazanin L, Pusic Sesar A, Ivekovic R, Vatavuk Z
Wien Klin Wochenschr 2025 Jan;137(1-2):13-15. Epub 2024 Apr 18 doi: 10.1007/s00508-024-02349-x. PMID: 38634909
Molecular landscape of eyelid sebaceous gland carcinoma: A comprehensive review.
Jayaraj P, Ray D, Goel K, Singh A, Kant N, Sen S
Indian J Ophthalmol 2024 Oct 1;72(10):1393-1403. Epub 2024 Sep 27 doi: 10.4103/IJO.IJO_167_24. PMID: 39331429Free PMC Article
Corneal melt with systemic chemotherapy in eyelid sebaceous gland carcinoma: Chemo-toxicity or tumor-necrosis-induced inflammation.
Meel R, Kumar N, Anand M, Bakhshi S
Indian J Ophthalmol 2024 May 1;72(5):757-758. Epub 2024 Apr 22 doi: 10.4103/IJO.IJO_1975_23. PMID: 38648442Free PMC Article
Development and validation of a nomogram to predict the recurrence of eyelid sebaceous gland carcinoma.
Nie Z, Geng J, Xu X, Zhang R, Li D
Cancer Med 2023 Jul;12(14):14912-14921. Epub 2023 Jun 30 doi: 10.1002/cam4.6126. PMID: 37387455Free PMC Article
Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians.
Kaliki S, Ayyar A, Dave TV, Ali MJ, Mishra DK, Naik MN
Eye (Lond) 2015 Jul;29(7):958-63. Epub 2015 May 22 doi: 10.1038/eye.2015.79. PMID: 25998946Free PMC Article

Therapy

Eyelid sebaceous gland carcinoma: a protocol for a systematic review and meta-analysis of clinicopathological studies of prevalence.
Thagaard MS, Vest SD, Heegaard S, Marcussen N
BMJ Open 2024 Jun 12;14(6):e086213. doi: 10.1136/bmjopen-2024-086213. PMID: 38866573Free PMC Article
The effect of direct cell injury inflicted by cryotherapy on eyelid sebaceous gland carcinoma cells: An ex-vivo experimental study.
Alam MS, Banerjee P, Krishnakumar S
Indian J Ophthalmol 2022 Feb;70(2):630-633. doi: 10.4103/ijo.IJO_1814_21. PMID: 35086251Free PMC Article
Neoadjuvant Systemic Chemotherapy in the Management of Extensive Eyelid Sebaceous Gland Carcinoma: A study of 10 Cases.
Kaliki S, Ayyar A, Nair AG, Mishra DK, Reddy VA, Naik MN
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):35-9. doi: 10.1097/IOP.0000000000000398. PMID: 25675161
Topical mitomycin-C for pagetoid invasion of the conjunctiva by eyelid sebaceous gland carcinoma.
Shields CL, Naseripour M, Shields JA, Eagle RC Jr
Ophthalmology 2002 Nov;109(11):2129-33. doi: 10.1016/s0161-6420(02)01239-3. PMID: 12414427

Prognosis

Molecular landscape of eyelid sebaceous gland carcinoma: A comprehensive review.
Jayaraj P, Ray D, Goel K, Singh A, Kant N, Sen S
Indian J Ophthalmol 2024 Oct 1;72(10):1393-1403. Epub 2024 Sep 27 doi: 10.4103/IJO.IJO_167_24. PMID: 39331429Free PMC Article
Development and validation of a nomogram to predict the recurrence of eyelid sebaceous gland carcinoma.
Nie Z, Geng J, Xu X, Zhang R, Li D
Cancer Med 2023 Jul;12(14):14912-14921. Epub 2023 Jun 30 doi: 10.1002/cam4.6126. PMID: 37387455Free PMC Article
Eyelid sebaceous gland carcinoma, validation of AJCC 8th edition T staging- a retrospective study from North India.
Sen S, Bhardwaj M, Jayaraj P, Bakhshi S, Pushker N, Kashyap S, Bajaj MS, Khandpur S
Acta Ophthalmol 2023 Feb;101(1):49-56. Epub 2022 Jun 24 doi: 10.1111/aos.15204. PMID: 35751173
ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma.
Bhardwaj M, Sen S, Sharma A, Kashyap S, Chosdol K, Pushker N, Bajaj MS, Bakhshi S
Hum Pathol 2015 Oct;46(10):1437-42. Epub 2015 Jun 10 doi: 10.1016/j.humpath.2015.05.026. PMID: 26220160
Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians.
Kaliki S, Ayyar A, Dave TV, Ali MJ, Mishra DK, Naik MN
Eye (Lond) 2015 Jul;29(7):958-63. Epub 2015 May 22 doi: 10.1038/eye.2015.79. PMID: 25998946Free PMC Article

Clinical prediction guides

Development and validation of a nomogram to predict the recurrence of eyelid sebaceous gland carcinoma.
Nie Z, Geng J, Xu X, Zhang R, Li D
Cancer Med 2023 Jul;12(14):14912-14921. Epub 2023 Jun 30 doi: 10.1002/cam4.6126. PMID: 37387455Free PMC Article
Eyelid sebaceous gland carcinoma, validation of AJCC 8th edition T staging- a retrospective study from North India.
Sen S, Bhardwaj M, Jayaraj P, Bakhshi S, Pushker N, Kashyap S, Bajaj MS, Khandpur S
Acta Ophthalmol 2023 Feb;101(1):49-56. Epub 2022 Jun 24 doi: 10.1111/aos.15204. PMID: 35751173
Eyelid sebaceous gland carcinoma: An assessment of the T classification of the American Joint Committee of Cancer TNM staging system 8th versus 7th edition.
AlHammad F, Edward DP, Alkatan HM, Elkhamary S, Iuliano A, Maktabi A, Al-Horani SE, Al-Sheikh O, Al Hussain H, Strianese D
Eur J Ophthalmol 2021 Jul;31(4):2055-2063. Epub 2020 Jun 21 doi: 10.1177/1120672120936488. PMID: 32567368
Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma.
Bhardwaj M, Sen S, Chosdol K, Bakhshi S, Pushker N, Sharma A, Kashyap S, Bajaj MS, Singh VK
Br J Ophthalmol 2020 Jun;104(6):879-884. Epub 2019 Apr 2 doi: 10.1136/bjophthalmol-2018-313285. PMID: 30940620
Sebaceous gland carcinoma of the eyelid: clinicopathological features and outcome in Asian Indians.
Kaliki S, Ayyar A, Dave TV, Ali MJ, Mishra DK, Naik MN
Eye (Lond) 2015 Jul;29(7):958-63. Epub 2015 May 22 doi: 10.1038/eye.2015.79. PMID: 25998946Free PMC Article

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