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Abnormal perifollicular morphology

MedGen UID:
1615717
Concept ID:
C4531226
Anatomical Abnormality
HPO: HP:0031285

Definition

Any structural anomaly in the areas surrounding the hair follicles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal perifollicular morphology

Conditions with this feature

Keratosis pilaris atrophicans
MedGen UID:
75520
Concept ID:
C0263428
Disease or Syndrome
Keratosis pilaris atrophicans (KPA) represents a group of rare genodermatoses characterized by perifollicular keratosis and inflammation that progresses to atrophy and scarring of the facial skin. Keratosis pilaris of extensor surfaces of limbs is a common associated finding. Affected individuals may present with features that overlap between 3 subtypes, keratosis pilaris atrophicans faciei (KPAF), keratosis follicularis spinulosa decalvans (KFSD), and atrophoderma vermiculata (AVA; see 209700) (summary by Klar et al., 2015).

Professional guidelines

PubMed

Greenzaid J, Nussbaum D, Friedman A
J Drugs Dermatol 2023 Oct 1;22(10):985-989. doi: 10.36849/JDD.7534. PMID: 37801530
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Kwiek B, Rożalski M, Sieczych J, Paluch Ł, Kowalewski C, Ambroziak M
Lasers Surg Med 2019 Sep;51(7):569-583. Epub 2019 Mar 12 doi: 10.1002/lsm.23083. PMID: 30860283

Recent clinical studies

Etiology

Lan X, Qiao R, Sun J, Song H, Gao M, Mo R, Song Z, Yang Y, Jiang Y
J Dermatol 2024 Feb;51(2):253-260. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17026. PMID: 38087855
Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Pangan AL, Robinson D
J Rheumatol 2001 Aug;28(8):1923-5. PMID: 11508601
Stevens HP, Kelsell DP, Bryant SP, Bishop DT, Dawber RP, Spurr NK, Leigh IM
J Invest Dermatol 1996 Apr;106(4):795-7. doi: 10.1111/1523-1747.ep12346400. PMID: 8618025

Diagnosis

Greenzaid J, Nussbaum D, Friedman A
J Drugs Dermatol 2023 Oct 1;22(10):985-989. doi: 10.36849/JDD.7534. PMID: 37801530
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Andrés-Ramos I, Alegría-Landa V, Gimeno I, Pérez-Plaza A, Rütten A, Kutzner H, Requena L
Am J Dermatopathol 2019 Feb;41(2):85-117. doi: 10.1097/DAD.0000000000001275. PMID: 30688725
Rudnicka L, Olszewska M, Rakowska A, Kowalska-Oledzka E, Slowinska M
J Drugs Dermatol 2008 Jul;7(7):651-4. PMID: 18664157
Frieden IJ, Prose NS, Fletcher V, Turner ML
Arch Dermatol 1989 Mar;125(3):369-73. PMID: 2923443

Therapy

Greenzaid J, Nussbaum D, Friedman A
J Drugs Dermatol 2023 Oct 1;22(10):985-989. doi: 10.36849/JDD.7534. PMID: 37801530
Lessing JN, LaMotte ED, Moshiri AS, Mark NM
Postgrad Med J 2015 Dec;91(1082):719-20. Epub 2015 Oct 27 doi: 10.1136/postgradmedj-2015-133661. PMID: 26508719
George SM, Taylor MR, Farrant PB
Clin Exp Dermatol 2015 Oct;40(7):717-21. Epub 2015 Jul 23 doi: 10.1111/ced.12715. PMID: 26202646
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Shvili D, David M, Mimouni M
Pediatr Dermatol 1987 May;4(1):21-3. doi: 10.1111/j.1525-1470.1987.tb00747.x. PMID: 2954034

Prognosis

Pimenta R, Borges-Costa J
Acta Dermatovenerol Croat 2019 Mar;27(1):49-50. PMID: 31032795
Lis-Święty A, Miziołek B, Ranosz-Janicka I, Bierzyńska-Macyszyn G, Brzezińska-Wcisło L
J Cosmet Dermatol 2018 Apr;17(2):268-273. Epub 2017 Jul 20 doi: 10.1111/jocd.12379. PMID: 28727235
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Carbillon L, Perrot N, Uzan M, Uzan S
Fetal Diagn Ther 2001 Nov-Dec;16(6):327-32. doi: 10.1159/000053936. PMID: 11694734
Sladkevicius P, Campbell S
Br Med Bull 2000;56(3):691-703. doi: 10.1258/0007142001903472. PMID: 11255554

Clinical prediction guides

Lan X, Qiao R, Sun J, Song H, Gao M, Mo R, Song Z, Yang Y, Jiang Y
J Dermatol 2024 Feb;51(2):253-260. Epub 2023 Dec 12 doi: 10.1111/1346-8138.17026. PMID: 38087855
Miracco C, DE Piano E, Marruganti C, Baldino G, Sorrentino E, Batsikosta A, Rubegni P, Angotti R, Messina M, Cinotti E
Ital J Dermatol Venerol 2022 Aug;157(4):342-347. Epub 2022 Jun 6 doi: 10.23736/S2784-8671.22.07301-7. PMID: 35666664
Pesqué D, Marcantonio O, Vázquez I, Papaleo N, Sánchez-González B, Gallardo F, Colomo L, Pujol RM
Am J Dermatopathol 2022 Apr 1;44(4):e41-e45. doi: 10.1097/DAD.0000000000002110. PMID: 34966050
Ubaldi F, Rienzi L
Placenta 2008 Oct;29 Suppl B:115-20. Epub 2008 Aug 31 doi: 10.1016/j.placenta.2008.08.009. PMID: 18762336
Kaya G, Augsburger E, Chavaz P, Saurat JH
J Cutan Pathol 2006 Mar;33(3):227-30. doi: 10.1111/j.0303-6987.2006.00463.x. PMID: 16466510

Recent systematic reviews

Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M
Exp Dermatol 2023 Jul;32(7):945-954. Epub 2023 May 4 doi: 10.1111/exd.14830. PMID: 37140216

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