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Focal sub-RPE deposits

MedGen UID:
1617013
•Concept ID:
C4531063
•
Finding
HPO: HP:0031532

Definition

Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in a single focus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal sub-RPE deposits

Recent clinical studies

Etiology

Optical coherence tomography features in vitreoretinal lymphoma compared with non-infectious uveitis.
El Zein L, Smith WM, White LJ, Hodge DO, Olsen TW, Pulido JS, Dalvin LA
BMC Ophthalmol 2024 Jun 13;24(1):255. doi: 10.1186/s12886-024-03513-7. PMID: 38872120Free PMC Article
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years.
Saßmannshausen M, Döngelci S, Vaisband M, von der Emde L, Sloan KR, Hasenauer J, Holz FG, Schmitz-Valckenberg S, Ach T
Invest Ophthalmol Vis Sci 2024 Apr 1;65(4):45. doi: 10.1167/iovs.65.4.45. PMID: 38687492Free PMC Article
Spectral-domain optical coherence tomography biomarkers in vitreoretinal lymphoma.
Guan W, Xiao Y, Zhao H, Hu F, Chen C, Peng X
Clin Exp Ophthalmol 2023 Mar;51(2):144-153. Epub 2023 Jan 4 doi: 10.1111/ceo.14197. PMID: 36567492
Multimodal imaging characteristics in eyes with vitreoretinal lymphoma treated with intravitreal rituximab.
Rishi P, Maitra P, Das K, Rishi E, Manchegowda PT
Int Ophthalmol 2021 Aug;41(8):2711-2722. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01828-8. PMID: 33834345
Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
Alcazar O, Hawkridge AM, Collier TS, Cousins SW, Bhattacharya SK, Muddiman DC, Marin-Castano ME
Mol Cell Proteomics 2009 Oct;8(10):2201-11. Epub 2009 Jun 29 doi: 10.1074/mcp.M900203-MCP200. PMID: 19567368Free PMC Article

Diagnosis

Spectral-domain optical coherence tomography biomarkers in vitreoretinal lymphoma.
Guan W, Xiao Y, Zhao H, Hu F, Chen C, Peng X
Clin Exp Ophthalmol 2023 Mar;51(2):144-153. Epub 2023 Jan 4 doi: 10.1111/ceo.14197. PMID: 36567492
Multimodal imaging characteristics in eyes with vitreoretinal lymphoma treated with intravitreal rituximab.
Rishi P, Maitra P, Das K, Rishi E, Manchegowda PT
Int Ophthalmol 2021 Aug;41(8):2711-2722. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01828-8. PMID: 33834345
HYPERSPECTRAL AUTOFLUORESCENCE IMAGING OF DRUSEN AND RETINAL PIGMENT EPITHELIUM IN DONOR EYES WITH AGE-RELATED MACULAR DEGENERATION.
Tong Y, Ben Ami T, Hong S, Heintzmann R, Gerig G, Ablonczy Z, Curcio CA, Ach T, Smith RT
Retina 2016 Dec;36 Suppl 1(Suppl 1):S127-S136. doi: 10.1097/IAE.0000000000001325. PMID: 28005671Free PMC Article
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography.
Zarranz-Ventura J, Sim DA, Keane PA, Patel PJ, Westcott MC, Lee RW, Tufail A, Pavesio CE
Ophthalmology 2014 Sep;121(9):1790-7. Epub 2014 May 20 doi: 10.1016/j.ophtha.2014.03.011. PMID: 24856311
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.
Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD
Hum Mol Genet 2007 Oct 15;16(20):2423-32. Epub 2007 Jul 30 doi: 10.1093/hmg/ddm199. PMID: 17664227

Therapy

Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.
Alcazar O, Hawkridge AM, Collier TS, Cousins SW, Bhattacharya SK, Muddiman DC, Marin-Castano ME
Mol Cell Proteomics 2009 Oct;8(10):2201-11. Epub 2009 Jun 29 doi: 10.1074/mcp.M900203-MCP200. PMID: 19567368Free PMC Article

Prognosis

Optical coherence tomography features in vitreoretinal lymphoma compared with non-infectious uveitis.
El Zein L, Smith WM, White LJ, Hodge DO, Olsen TW, Pulido JS, Dalvin LA
BMC Ophthalmol 2024 Jun 13;24(1):255. doi: 10.1186/s12886-024-03513-7. PMID: 38872120Free PMC Article
Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years.
Saßmannshausen M, Döngelci S, Vaisband M, von der Emde L, Sloan KR, Hasenauer J, Holz FG, Schmitz-Valckenberg S, Ach T
Invest Ophthalmol Vis Sci 2024 Apr 1;65(4):45. doi: 10.1167/iovs.65.4.45. PMID: 38687492Free PMC Article
Multimodal imaging characteristics in eyes with vitreoretinal lymphoma treated with intravitreal rituximab.
Rishi P, Maitra P, Das K, Rishi E, Manchegowda PT
Int Ophthalmol 2021 Aug;41(8):2711-2722. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01828-8. PMID: 33834345
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.
Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD
Hum Mol Genet 2007 Oct 15;16(20):2423-32. Epub 2007 Jul 30 doi: 10.1093/hmg/ddm199. PMID: 17664227

Clinical prediction guides

Spectral-domain optical coherence tomography biomarkers in vitreoretinal lymphoma.
Guan W, Xiao Y, Zhao H, Hu F, Chen C, Peng X
Clin Exp Ophthalmol 2023 Mar;51(2):144-153. Epub 2023 Jan 4 doi: 10.1111/ceo.14197. PMID: 36567492
Multimodal imaging characteristics in eyes with vitreoretinal lymphoma treated with intravitreal rituximab.
Rishi P, Maitra P, Das K, Rishi E, Manchegowda PT
Int Ophthalmol 2021 Aug;41(8):2711-2722. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01828-8. PMID: 33834345
Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography.
Zarranz-Ventura J, Sim DA, Keane PA, Patel PJ, Westcott MC, Lee RW, Tufail A, Pavesio CE
Ophthalmology 2014 Sep;121(9):1790-7. Epub 2014 May 20 doi: 10.1016/j.ophtha.2014.03.011. PMID: 24856311
Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium.
Seo SJ, Krebs MP, Mao H, Jones K, Conners M, Lewin AS
Exp Eye Res 2012 Aug;101:60-71. Epub 2012 Jun 8 doi: 10.1016/j.exer.2012.05.013. PMID: 22687918Free PMC Article
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.
Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD
Hum Mol Genet 2007 Oct 15;16(20):2423-32. Epub 2007 Jul 30 doi: 10.1093/hmg/ddm199. PMID: 17664227

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