U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Pancreatic Neuroendocrine Carcinoma

MedGen UID:
1617685
•Concept ID:
C4527255
•
Neoplastic Process

Definition

Pancreatic neuroendocrine carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Pancreatic Neuroendocrine Carcinoma

Professional guidelines

PubMed

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers.
Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A
Am J Clin Oncol 2012 Apr;35(2):167-77. doi: 10.1097/COC.0b013e3181f47923. PMID: 21127414
Diagnosis and treatment of gastrinoma in the era of proton pump inhibitors.
Banasch M, Schmitz F
Wien Klin Wochenschr 2007;119(19-20):573-8. doi: 10.1007/s00508-007-0884-2. PMID: 17985090

Recent clinical studies

Etiology

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review.
Bonaccorsi-Riani E, Apestegui C, Jouret-Mourin A, Sempoux C, Goffette P, Ciccarelli O, Borbath I, Hubert C, Gigot JF, Hassoun Z, Lerut J
Transpl Int 2010 Jul;23(7):668-78. Epub 2010 May 5 doi: 10.1111/j.1432-2277.2010.01086.x. PMID: 20478000
Islet cell tumors of the pancreas.
Bieligk S, Jaffe BM
Surg Clin North Am 1995 Oct;75(5):1025-40. doi: 10.1016/s0039-6109(16)46744-7. PMID: 7660247

Diagnosis

Belzutifan in a Patient With VHL-Associated Metastatic Pancreatic Neuroendocrine Tumor.
Pelle E, Al-Toubah T, Morse B, Strosberg J
J Natl Compr Canc Netw 2022 Dec;20(12):1285-1287. doi: 10.6004/jnccn.2022.7047. PMID: 36509068
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Zollinger-Ellison syndrome: classical considerations and current controversies.
Epelboym I, Mazeh H
Oncologist 2014 Jan;19(1):44-50. Epub 2013 Dec 6 doi: 10.1634/theoncologist.2013-0369. PMID: 24319020Free PMC Article
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Brentjens R, Saltz L
Surg Clin North Am 2001 Jun;81(3):527-42. doi: 10.1016/s0039-6109(05)70141-9. PMID: 11459269

Therapy

Emerging therapies for advanced insulinomas and glucagonomas.
Alexandraki KI, Kaltsas GA, Grozinsky-Glasberg S
Endocr Relat Cancer 2023 Sep 1;30(9) Epub 2023 Aug 7 doi: 10.1530/ERC-23-0020. PMID: 37343152
Molecular basis and targeted therapy in thyroid cancer: Progress and opportunities.
Zhang L, Feng Q, Wang J, Tan Z, Li Q, Ge M
Biochim Biophys Acta Rev Cancer 2023 Jul;1878(4):188928. Epub 2023 May 29 doi: 10.1016/j.bbcan.2023.188928. PMID: 37257629
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Chemotherapy for advanced poorly differentiated pancreatic neuroendocrine carcinoma.
Ikeda M, Okuyama H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Kondo S, Morizane C, Ueno H, Okusaka T
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):623-7. Epub 2015 Mar 5 doi: 10.1002/jhbp.228. PMID: 25755102
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Brentjens R, Saltz L
Surg Clin North Am 2001 Jun;81(3):527-42. doi: 10.1016/s0039-6109(05)70141-9. PMID: 11459269

Prognosis

Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma.
Pothuri VS, Hogg GD, Conant L, Borcherding N, James CA, Mudd J, Williams G, Seo YD, Hawkins WG, Pillarisetty VG, DeNardo DG, Fields RC
Oncoimmunology 2024;13(1):2320411. Epub 2024 Mar 15 doi: 10.1080/2162402X.2024.2320411. PMID: 38504847Free PMC Article
Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Liver transplantation and neuroendocrine tumors: lessons from a single centre experience and from the literature review.
Bonaccorsi-Riani E, Apestegui C, Jouret-Mourin A, Sempoux C, Goffette P, Ciccarelli O, Borbath I, Hubert C, Gigot JF, Hassoun Z, Lerut J
Transpl Int 2010 Jul;23(7):668-78. Epub 2010 May 5 doi: 10.1111/j.1432-2277.2010.01086.x. PMID: 20478000
Vasoactive intestinal polypeptide-secreting tumours: biology and therapy.
Park SK, O'Dorisio MS, O'Dorisio TM
Baillieres Clin Gastroenterol 1996 Dec;10(4):673-96. doi: 10.1016/s0950-3528(96)90018-4. PMID: 9113317

Clinical prediction guides

Outcomes Analysis of Yttrium-90 Radioembolization for Tumors Other Than Metastatic Colorectal Cancer from the Radiation-Emitting SIR-Spheres in Nonresectable (RESiN) Registry.
Zhou W, Du L, Brown DB, Shah RP, Sze DY
J Vasc Interv Radiol 2024 Nov;35(11):1591-1600.e3. Epub 2024 Jul 14 doi: 10.1016/j.jvir.2024.07.006. PMID: 39009301
Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma.
Pothuri VS, Hogg GD, Conant L, Borcherding N, James CA, Mudd J, Williams G, Seo YD, Hawkins WG, Pillarisetty VG, DeNardo DG, Fields RC
Oncoimmunology 2024;13(1):2320411. Epub 2024 Mar 15 doi: 10.1080/2162402X.2024.2320411. PMID: 38504847Free PMC Article
Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Expression of liver X receptors in normal and refractory carcinoma tissues of the human lung and pancreas.
Kashiwagi K, Yanagida M, Matsui D, Tanaka M, Sugimoto K, Chen H, Ichikawa-Tomikawa N, Marubashi S, Suzuki H, Chiba H
Histol Histopathol 2018 May;33(5):497-505. Epub 2017 Nov 28 doi: 10.14670/HH-11-949. PMID: 29181837
Radioembolization of liver tumors with yttrium-90 microspheres.
Ahmadzadehfar H, Biersack HJ, Ezziddin S
Semin Nucl Med 2010 Mar;40(2):105-21. doi: 10.1053/j.semnuclmed.2009.11.001. PMID: 20113679

Recent systematic reviews

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...