Basal-Like Prostate Carcinoma

MedGen UID:: 1621429
•Concept ID:: C4527417
•: Neoplastic Process

Synonym:

Basal-Like Prostate Cancer

Definition

Prostate carcinoma in which the CD49f signature is increased, the luminal markers and androgen receptor expression and signaling (androgen activity pathway) are not increased, and the proliferation score is higher than the luminal A prostate carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBasal-Like Prostate Carcinoma

Epithelial neoplasm
- Carcinoma
  - Genitourinary System Carcinoma
    - Male Reproductive System Carcinoma
      - Prostate carcinoma
        Prostate Carcinoma by Gene Expression Profile
        Basal-Like Prostate Carcinoma

Recent clinical studies

Etiology

TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis.

Galoczova M, Nenutil R, Pokorna Z, Vojtesek B, Coates PJ
Virchows Arch 2021 Apr;478(4):627-636. Epub 2020 Oct 10 doi: 10.1007/s00428-020-02944-z. PMID: 33037932

Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.

Tan HL, Haffner MC, Esopi DM, Vaghasia AM, Giannico GA, Ross HM, Ghosh S, Hicks JL, Zheng Q, Sangoi AR, Yegnasubramanian S, Osunkoya AO, De Marzo AM, Epstein JI, Lotan TL
Mod Pathol 2015 Mar;28(3):446-56. Epub 2014 Sep 12 doi: 10.1038/modpathol.2014.115. PMID: 25216229 Free PMC Article

See all (2)

Diagnosis

Subtype Transdifferentiation in Human Cancer: The Power of Tissue Plasticity in Tumor Progression.

Fedele M, Cerchia L, Battista S
Cells 2024 Feb 17;13(4) doi: 10.3390/cells13040350. PMID: 38391963 Free PMC Article

Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Genitsch V, Kollár A, Vandekerkhove G, Blarer J, Furrer M, Annala M, Herberts C, Pycha A, de Jong JJ, Liu Y, Krentel F, Davicioni E, Gibb EA, Kruithof-de Julio M, Wyatt AW, Seiler R
Urol Oncol 2019 Nov;37(11):826-836. Epub 2019 Oct 1 doi: 10.1016/j.urolonc.2019.09.025. PMID: 31585777

Olfactory receptor gene abundance in invasive breast carcinoma.

Masjedi S, Zwiebel LJ, Giorgio TD
Sci Rep 2019 Sep 24;9(1):13736. doi: 10.1038/s41598-019-50085-4. PMID: 31551495 Free PMC Article

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691

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Therapy

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

See all (1)

Prognosis

Subtype Transdifferentiation in Human Cancer: The Power of Tissue Plasticity in Tumor Progression.

Fedele M, Cerchia L, Battista S
Cells 2024 Feb 17;13(4) doi: 10.3390/cells13040350. PMID: 38391963 Free PMC Article

Morphologic and genomic characterization of urothelial to sarcomatoid transition in muscle-invasive bladder cancer.

Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas.

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies.

Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW
Oncotarget 2014 Mar 30;5(6):1458-74. doi: 10.18632/oncotarget.1538. PMID: 24681547 Free PMC Article

18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.

Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, Kastenhuber ER, Taschereau R, Plaisier SB, Tran C, Heguy A, Wu H, Sander C, Phelps ME, Brennan C, Port E, Huse JT, Graeber TG, Mellinghoff IK
Cancer Res 2011 Aug 1;71(15):5164-74. Epub 2011 Jun 6 doi: 10.1158/0008-5472.CAN-10-4633. PMID: 21646475 Free PMC Article

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