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Luminal A Prostate Carcinoma

MedGen UID:
1624277
Concept ID:
C4527415
Neoplastic Process
Synonym: Luminal A Prostate Cancer

Definition

Prostate carcinoma associated with increased androgen receptor expression and signaling (androgen activity pathway), increased luminal markers, and a lower proliferation score than the luminal B and basal-like prostate carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLuminal A Prostate Carcinoma

Professional guidelines

PubMed

Carreras MJ, Tomás-Guillén E, Farriols A, Renedo-Miró B, Valdivia C, Vidal J, Saura C, Carles J, Felip E, Gorgas MQ, Tabernero J, Monterde J
Curr Oncol 2023 Aug 30;30(9):7984-8004. doi: 10.3390/curroncol30090580. PMID: 37754495Free PMC Article
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
González Del Alba A, Arranz JÁ, Puente J, Méndez-Vidal MJ, Gallardo E, Grande E, Pérez-Valderrama B, González-Billalabeitia E, Lázaro-Quintela M, Pinto Á, Lainez N, Piulats JM, Esteban E, Maroto Rey JP, García JA, Suárez C
Crit Rev Oncol Hematol 2017 May;113:171-190. Epub 2017 Mar 14 doi: 10.1016/j.critrevonc.2017.03.010. PMID: 28427506

Recent clinical studies

Etiology

Graham LS, Haffner MC, Sayar E, Gawne A, Schweizer MT, Pritchard CC, Coleman I, Nelson PS, Yu EY
Prostate 2023 May;83(7):641-648. Epub 2023 Feb 13 doi: 10.1002/pros.24497. PMID: 36779357Free PMC Article
Storck WK, May AM, Westbrook TC, Duan Z, Morrissey C, Yates JA, Alumkal JJ
Front Endocrinol (Lausanne) 2022;13:926585. Epub 2022 Jul 14 doi: 10.3389/fendo.2022.926585. PMID: 35909568Free PMC Article
Mikoshi A, Miyai K, Hamabe F, Edo H, Ito K, Matsukuma S, Tsuda H, Shinmoto H
Prostate 2022 Mar;82(4):452-463. Epub 2021 Dec 28 doi: 10.1002/pros.24291. PMID: 34964158
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
Huang YH, Zhang YQ, Huang JT
Asian J Androl 2019 May-Jun;21(3):291-295. doi: 10.4103/aja.aja_128_18. PMID: 30924452Free PMC Article

Diagnosis

Romero R, Chu T, González Robles TJ, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina MV, Lawrence KE, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus WR, DeStanchina E, Ruggles KV, Westcott PMK, Chaligné R, Pe'er D, Sawyers CL
Nat Cancer 2024 Nov;5(11):1641-1659. Epub 2024 Oct 11 doi: 10.1038/s43018-024-00838-6. PMID: 39394434Free PMC Article
Fedele M, Cerchia L, Battista S
Cells 2024 Feb 17;13(4) doi: 10.3390/cells13040350. PMID: 38391963Free PMC Article
Samaratunga H, Delahunt B, Yaxley JW, Johannsen S, Egevad L
Am J Surg Pathol 2021 Nov 1;45(11):1527-1533. doi: 10.1097/PAS.0000000000001776. PMID: 34265803
Beltran H, Demichelis F
Endocr Relat Cancer 2021 Jul 15;28(8):T67-T78. doi: 10.1530/ERC-21-0140. PMID: 34111024Free PMC Article
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068

Therapy

Storck WK, May AM, Westbrook TC, Duan Z, Morrissey C, Yates JA, Alumkal JJ
Front Endocrinol (Lausanne) 2022;13:926585. Epub 2022 Jul 14 doi: 10.3389/fendo.2022.926585. PMID: 35909568Free PMC Article
Han H, Lee HH, Choi K, Moon YJ, Heo JE, Ham WS, Jang WS, Rha KH, Cho NH, Giancotti FG, Choi YD
Prostate Cancer Prostatic Dis 2021 Dec;24(4):1080-1092. Epub 2021 Apr 26 doi: 10.1038/s41391-021-00364-x. PMID: 33903734Free PMC Article
Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
Clin Cancer Res 2019 Apr 15;25(8):2450-2457. Epub 2018 Dec 20 doi: 10.1158/1078-0432.CCR-18-3121. PMID: 30573691
Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H, Huang J
Asian J Androl 2014 Jul-Aug;16(4):541-4. doi: 10.4103/1008-682X.123669. PMID: 24589459Free PMC Article
Smith JA Jr
J Urol 1994 Jul;152(1):132-4. doi: 10.1016/s0022-5347(17)32835-5. PMID: 8201642

Prognosis

Fedele M, Cerchia L, Battista S
Cells 2024 Feb 17;13(4) doi: 10.3390/cells13040350. PMID: 38391963Free PMC Article
Samaratunga H, Delahunt B, Yaxley JW, Johannsen S, Egevad L
Am J Surg Pathol 2021 Nov 1;45(11):1527-1533. doi: 10.1097/PAS.0000000000001776. PMID: 34265803
Beltran H, Demichelis F
Endocr Relat Cancer 2021 Jul 15;28(8):T67-T78. doi: 10.1530/ERC-21-0140. PMID: 34111024Free PMC Article
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
Humphrey PA
Mod Pathol 2018 Jan;31(S1):S64-70. doi: 10.1038/modpathol.2017.137. PMID: 29297496

Clinical prediction guides

Fedele M, Cerchia L, Battista S
Cells 2024 Feb 17;13(4) doi: 10.3390/cells13040350. PMID: 38391963Free PMC Article
Rade M, Kreuz M, Borkowetz A, Sommer U, Blumert C, Füssel S, Bertram C, Löffler D, Otto DJ, Wöller LA, Schimmelpfennig C, Köhl U, Gottschling AC, Hönscheid P, Baretton GB, Wirth M, Thomas C, Horn F, Reiche K
Mol Med 2024 Feb 1;30(1):19. doi: 10.1186/s10020-024-00789-9. PMID: 38302875Free PMC Article
Samaratunga H, Delahunt B, Yaxley JW, Johannsen S, Egevad L
Am J Surg Pathol 2021 Nov 1;45(11):1527-1533. doi: 10.1097/PAS.0000000000001776. PMID: 34265803
Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
Humphrey PA
Mod Pathol 2018 Jan;31(S1):S64-70. doi: 10.1038/modpathol.2017.137. PMID: 29297496

Recent systematic reviews

Huang YH, Zhang YQ, Huang JT
Asian J Androl 2019 May-Jun;21(3):291-295. doi: 10.4103/aja.aja_128_18. PMID: 30924452Free PMC Article

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