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Polypoidal choroidal vasculopathy

MedGen UID:
1630949
Concept ID:
C1504336
Disease or Syndrome
Synonyms: Choroidal Vasculopathies, Polypoidal; Choroidal Vasculopathy, Polypoidal; Polypoidal Choroidal Vasculopathies; Polypoidal Choroidal Vasculopathy; Vasculopathy, Polypoidal Choroidal
SNOMED CT: Polypoidal choroidal vasculopathy (1162974001); PCV - polypoidal choroidal vasculopathy (1162974001)
 
HPO: HP:0025569

Definition

The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolypoidal choroidal vasculopathy

Professional guidelines

PubMed

Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
Cheung CMG, Lai TYY, Ruamviboonsuk P, Chen SJ, Chen Y, Freund KB, Gomi F, Koh AH, Lee WK, Wong TY
Ophthalmology 2018 May;125(5):708-724. Epub 2018 Jan 10 doi: 10.1016/j.ophtha.2017.11.019. PMID: 29331556
Tan CS, Lim TH, Hariprasad SM
Ophthalmic Surg Lasers Imaging Retina 2015 Sep;46(8):786-91. doi: 10.3928/23258160-20150909-02. PMID: 26431293

Recent clinical studies

Etiology

Sharma A, Parachuri N, Kumar N, Kuppermann BD, Loewenstein A, Bandello F
Expert Opin Biol Ther 2022 Jul;22(7):809-812. Epub 2022 Jun 27 doi: 10.1080/14712598.2022.2094239. PMID: 35737884
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
Lam WC, Choudhry N, Wong D
Can J Ophthalmol 2020 Jun;55(3):199-211. Epub 2019 Dec 24 doi: 10.1016/j.jcjo.2019.10.011. PMID: 31879067
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438
Ciardella AP, Donsoff IM, Yannuzzi LA
Ophthalmol Clin North Am 2002 Dec;15(4):537-54. doi: 10.1016/s0896-1549(02)00053-6. PMID: 12515086

Diagnosis

Borooah S, Sim PY, Phatak S, Moraes G, Wu CY, Cheung CMG, Pal B, Bujarborua D
Acta Ophthalmol 2021 Sep;99(6):e806-e822. Epub 2020 Nov 30 doi: 10.1111/aos.14683. PMID: 33258304
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
Lam WC, Choudhry N, Wong D
Can J Ophthalmol 2020 Jun;55(3):199-211. Epub 2019 Dec 24 doi: 10.1016/j.jcjo.2019.10.011. PMID: 31879067
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438
Ciardella AP, Donsoff IM, Yannuzzi LA
Ophthalmol Clin North Am 2002 Dec;15(4):537-54. doi: 10.1016/s0896-1549(02)00053-6. PMID: 12515086

Therapy

Sharma A, Parachuri N, Kumar N, Kuppermann BD, Loewenstein A, Bandello F
Expert Opin Biol Ther 2022 Jul;22(7):809-812. Epub 2022 Jun 27 doi: 10.1080/14712598.2022.2094239. PMID: 35737884
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, Gomi F, Koh AH, Kokame G, Jordan-Yu JM, Corvi F, Invernizzi A, Ogura Y, Tan C, Mitchell P, Gupta V, Chhablani J, Chakravarthy U, Sadda SR, Wong TY, Staurenghi G, Lee WK
Ophthalmology 2021 Mar;128(3):443-452. Epub 2020 Aug 11 doi: 10.1016/j.ophtha.2020.08.006. PMID: 32795496
Lam WC, Choudhry N, Wong D
Can J Ophthalmol 2020 Jun;55(3):199-211. Epub 2019 Dec 24 doi: 10.1016/j.jcjo.2019.10.011. PMID: 31879067
Lee WK, Iida T, Ogura Y, Chen SJ, Wong TY, Mitchell P, Cheung GCM, Zhang Z, Leal S, Ishibashi T; PLANET Investigators
JAMA Ophthalmol 2018 Jul 1;136(7):786-793. doi: 10.1001/jamaophthalmol.2018.1804. PMID: 29801063Free PMC Article
Ciardella AP, Donsoff IM, Yannuzzi LA
Ophthalmol Clin North Am 2002 Dec;15(4):537-54. doi: 10.1016/s0896-1549(02)00053-6. PMID: 12515086

Prognosis

Chaikitmongkol V, Cheung CMG, Koizumi H, Govindahar V, Chhablani J, Lai TYY
Asia Pac J Ophthalmol (Phila) 2020 May-Jun;9(3):260-268. doi: 10.1097/01.APO.0000656992.00746.48. PMID: 32332215Free PMC Article
Anantharaman G, Sheth J, Bhende M, Narayanan R, Natarajan S, Rajendran A, Manayath G, Sen P, Biswas R, Banker A, Gupta C
Indian J Ophthalmol 2018 Jul;66(7):896-908. doi: 10.4103/ijo.IJO_1136_17. PMID: 29941728Free PMC Article
Shin MK, Lee JE, Byon IS, Park SW
Curr Eye Res 2017 Feb;42(2):252-259. Epub 2016 Jul 11 doi: 10.1080/02713683.2016.1183794. PMID: 27400136
Honda S, Matsumiya W, Negi A
Ophthalmologica 2014;231(2):59-74. Epub 2013 Nov 21 doi: 10.1159/000355488. PMID: 24280967
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Clinical prediction guides

Bo Q, Zhang M, Chen J, Jia H, Shen M, Sun M, Xu M, Feng J, Yan Q, Yu Y, Huang P, Li T, Wang F, Rosenfeld PJ, Sun X
Ophthalmology 2023 Feb;130(2):167-178. Epub 2022 Sep 22 doi: 10.1016/j.ophtha.2022.09.013. PMID: 36152843
Zhang X, Sivaprasad S
Eye (Lond) 2021 Jan;35(1):121-133. Epub 2020 Nov 18 doi: 10.1038/s41433-020-01265-4. PMID: 33208847Free PMC Article
Lee WK, Iida T, Ogura Y, Chen SJ, Wong TY, Mitchell P, Cheung GCM, Zhang Z, Leal S, Ishibashi T; PLANET Investigators
JAMA Ophthalmol 2018 Jul 1;136(7):786-793. doi: 10.1001/jamaophthalmol.2018.1804. PMID: 29801063Free PMC Article
Qian T, Li X, Zhao M, Xu X
Eur J Clin Invest 2018 Jan;48(1) Epub 2017 Dec 18 doi: 10.1111/eci.12840. PMID: 28981139Free PMC Article
Pang CE, Freund KB
Retina 2015 Jan;35(1):1-9. doi: 10.1097/IAE.0000000000000331. PMID: 25158945

Recent systematic reviews

Mihalache A, Hatamnejad A, Patil NS, Popovic MM, Muni RH, Kertes PJ, Wong DT
Ophthalmologica 2023;246(3-4):245-254. Epub 2023 Aug 17 doi: 10.1159/000533529. PMID: 37591212Free PMC Article
Hatamnejad A, Patil NS, Mihalache A, Popovic MM, Kertes PJ, Muni RH, Wong DT
Surv Ophthalmol 2023 Sep-Oct;68(5):920-928. Epub 2023 May 3 doi: 10.1016/j.survophthal.2023.04.002. PMID: 37146693
Liu L, Tham YC, Wu J, Yue S, Cheng CY
Photodiagnosis Photodyn Ther 2017 Dec;20:215-220. Epub 2017 Sep 19 doi: 10.1016/j.pdpdt.2017.09.008. PMID: 28935532
Wong CW, Cheung CM, Mathur R, Li X, Chan CM, Yeo I, Wong E, Lee SY, Wong D, Wong TY
Retina 2015 Aug;35(8):1577-93. doi: 10.1097/IAE.0000000000000499. PMID: 25719986
Chen H, Liu K, Chen LJ, Hou P, Chen W, Pang CP
Mol Vis 2012;18:816-29. Epub 2012 Apr 4 PMID: 22509112Free PMC Article

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