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Post-Mastectomy Pain Syndrome

MedGen UID:
1631351
•Concept ID:
C4682758
•
Disease or Syndrome

Definition

Chronic pain following mastectomy or lumpectomy that usually affects the anterior thorax, axilla, and/or medial upper arm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-Mastectomy Pain Syndrome

Professional guidelines

PubMed

Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
The Post-mastectomy Pain Syndrome-A Systematic Review of the Treatment Modalities.
Larsson IM, Ahm Sørensen J, Bille C
Breast J 2017 May;23(3):338-343. Epub 2017 Jan 30 doi: 10.1111/tbj.12739. PMID: 28133848

Recent clinical studies

Etiology

Exercise Therapy in Oncology.
Baumann FT, Jensen W, Berling-Ernst A, Theurich S, Leitzmann M, Götte M
Dtsch Arztebl Int 2024 May 17;121(10):331-337. doi: 10.3238/arztebl.m2024.0038. PMID: 38509786Free PMC Article
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
Post-mastectomy pain syndrome: incidence and risks.
Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahão K, da Costa Leite Ferreira MG, de Almeida Dias R, Santos Thuler LC
Breast 2012 Jun;21(3):321-5. Epub 2012 Feb 27 doi: 10.1016/j.breast.2012.01.019. PMID: 22377590
Post-mastectomy pain syndrome: the magnitude of the problem.
Couceiro TC, Menezes TC, Valênça MM
Rev Bras Anestesiol 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. PMID: 19488550

Diagnosis

Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial.
Khan JS, Gilron I, Devereaux PJ, Clarke H, Ayach N, Tomlinson G, Quan ML, Ladha KS, Choi S, Munro A, Brull R, Lim DW, Avramescu S, Richebé P, Hodgson N, Paul J, McIsaac DI, Derzi S, Zbitnew GL, Easson AM, Siddiqui NT, Miles SJ, Karkouti K; PLAN Trial Investigators
Trials 2024 May 22;25(1):337. doi: 10.1186/s13063-024-08151-4. PMID: 38773653Free PMC Article
Exercise Therapy in Oncology.
Baumann FT, Jensen W, Berling-Ernst A, Theurich S, Leitzmann M, Götte M
Dtsch Arztebl Int 2024 May 17;121(10):331-337. doi: 10.3238/arztebl.m2024.0038. PMID: 38509786Free PMC Article
Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Post-breast surgery pain syndrome: establishing a consensus for the definition of post-mastectomy pain syndrome to provide a standardized clinical and research approach - a review of the literature and discussion.
Waltho D, Rockwell G
Can J Surg 2016 Sep;59(5):342-50. doi: 10.1503/cjs.000716. PMID: 27668333Free PMC Article
Post-mastectomy pain syndrome: the magnitude of the problem.
Couceiro TC, Menezes TC, Valênça MM
Rev Bras Anestesiol 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. PMID: 19488550

Therapy

Interventional Treatment Options for Post-mastectomy Pain.
Murugappan A, Khanna A
Curr Oncol Rep 2023 Oct;25(10):1175-1179. Epub 2023 Aug 30 doi: 10.1007/s11912-023-01435-z. PMID: 37646901
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Persistent Post-Mastectomy Pain: Risk Factors and Current Approaches to Treatment.
Tait RC, Zoberi K, Ferguson M, Levenhagen K, Luebbert RA, Rowland K, Salsich GB, Herndon C
J Pain 2018 Dec;19(12):1367-1383. Epub 2018 Jun 30 doi: 10.1016/j.jpain.2018.06.002. PMID: 29966772Free PMC Article
A review of the literature and discussion: establishing a consensus for the definition of post-mastectomy pain syndrome to provide a standardized clinical and research approach.
Brackstone M
Can J Surg 2016 Sep;59(5):294-5. doi: 10.1503/cjs.012016. PMID: 27668326Free PMC Article
Post-mastectomy pain syndrome: incidence and risks.
Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahão K, da Costa Leite Ferreira MG, de Almeida Dias R, Santos Thuler LC
Breast 2012 Jun;21(3):321-5. Epub 2012 Feb 27 doi: 10.1016/j.breast.2012.01.019. PMID: 22377590

Prognosis

Intraoperative infusion of esmolol reduces the incidence and intensity of post-mastectomy pain syndrome.
Mendonça FT, Volpe Júnior JF, Tramontini AJ, DE Carvalho LS, Sposito AC
Minerva Anestesiol 2022 May;88(5):414-415. Epub 2021 Oct 12 doi: 10.23736/S0375-9393.21.16152-8. PMID: 34636226
Single institution analysis of incidence and risk factors for post-mastectomy pain syndrome.
Cui L, Fan P, Qiu C, Hong Y
Sci Rep 2018 Jul 31;8(1):11494. doi: 10.1038/s41598-018-29946-x. PMID: 30065342Free PMC Article
Prevalence of post-mastectomy pain syndrome and associated risk factors: a cross-sectional cohort study.
Couceiro TC, Valença MM, Raposo MC, Orange FA, Amorim MM
Pain Manag Nurs 2014 Dec;15(4):731-7. Epub 2013 Oct 19 doi: 10.1016/j.pmn.2013.07.011. PMID: 24144570
Post-mastectomy pain syndrome: incidence and risks.
Alves Nogueira Fabro E, Bergmann A, do Amaral E Silva B, Padula Ribeiro AC, de Souza Abrahão K, da Costa Leite Ferreira MG, de Almeida Dias R, Santos Thuler LC
Breast 2012 Jun;21(3):321-5. Epub 2012 Feb 27 doi: 10.1016/j.breast.2012.01.019. PMID: 22377590
Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome.
Macdonald L, Bruce J, Scott NW, Smith WC, Chambers WA
Br J Cancer 2005 Jan 31;92(2):225-30. doi: 10.1038/sj.bjc.6602304. PMID: 15655557Free PMC Article

Clinical prediction guides

Post mastectomy pain syndrome at an Indian tertiary cancer centre and its impact on quality of life.
Kakati B, Nair N, Chatterjee A
Indian J Cancer 2023 Apr-Jun;60(2):275-281. doi: 10.4103/ijc.ijc_861_21. PMID: 37530253
Postmastectomy pain syndrome after preoperative stellate ganglion block: a randomized controlled trial.
Salman AS, Abbas DN, Elrawas MM, Kamel MA, Mohammed AM, Abouel Soud AH, Abdelgalil AS
Minerva Anestesiol 2021 Jul;87(7):786-793. Epub 2021 May 3 doi: 10.23736/S0375-9393.21.15112-0. PMID: 33938674
Radiofrequency Thoracic Sympathectomy for Sympathetically Maintained Chronic Post-Mastectomy Pain, a Preliminary Report: 6-Month Results.
Hetta DF, Mohamed AA, Hetta HF, Abd El-Hakeem EE, Boshra MM, El-Barody MM, Fattah Mohammad MA
Pain Pract 2021 Jan;21(1):54-63. Epub 2020 Aug 4 doi: 10.1111/papr.12933. PMID: 32629535
Prevalence of post-mastectomy pain syndrome and associated risk factors: a cross-sectional cohort study.
Couceiro TC, Valença MM, Raposo MC, Orange FA, Amorim MM
Pain Manag Nurs 2014 Dec;15(4):731-7. Epub 2013 Oct 19 doi: 10.1016/j.pmn.2013.07.011. PMID: 24144570
Long-term follow-up of breast cancer survivors with post-mastectomy pain syndrome.
Macdonald L, Bruce J, Scott NW, Smith WC, Chambers WA
Br J Cancer 2005 Jan 31;92(2):225-30. doi: 10.1038/sj.bjc.6602304. PMID: 15655557Free PMC Article

Recent systematic reviews

The Efficacy of Fat Grafting on Treating Post-Mastectomy Pain with and without Breast Reconstruction: A Systematic Review and Meta-Analysis.
Chen J, Alghamdi AA, Wong CY, Alnaim MF, Kuper G, Zhang J
Curr Oncol 2024 Apr 4;31(4):2057-2066. doi: 10.3390/curroncol31040152. PMID: 38668055Free PMC Article
Novel Prevention Approaches of Breast Cancer Surgery Related Complications: Systematic Review and Network Meta-Analysis.
Dzhantemirova N, Ahmedin D, Khasenov D, Khakimova G, Khakimova S, Bekisheva A, Mauletbaev M, Makishev A
Asian Pac J Cancer Prev 2024 Jan 1;25(1):9-23. doi: 10.31557/APJCP.2024.25.1.9. PMID: 38285764Free PMC Article
Efficacy of physical therapy interventions on quality of life and upper quadrant pain severity in women with post-mastectomy pain syndrome: a systematic review and meta-analysis.
Kannan P, Lam HY, Ma TK, Lo CN, Mui TY, Tang WY
Qual Life Res 2022 Apr;31(4):951-973. Epub 2021 Jun 29 doi: 10.1007/s11136-021-02926-x. PMID: 34185226Free PMC Article
Prevalence of pain in patients with breast cancer post-treatment: A systematic review.
Wang K, Yee C, Tam S, Drost L, Chan S, Zaki P, Rico V, Ariello K, Dasios M, Lam H, DeAngelis C, Chow E
Breast 2018 Dec;42:113-127. Epub 2018 Sep 4 doi: 10.1016/j.breast.2018.08.105. PMID: 30243159
The Post-mastectomy Pain Syndrome-A Systematic Review of the Treatment Modalities.
Larsson IM, Ahm Sørensen J, Bille C
Breast J 2017 May;23(3):338-343. Epub 2017 Jan 30 doi: 10.1111/tbj.12739. PMID: 28133848

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