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Anterior chamber flare grade 1+

MedGen UID:
1633105
•Concept ID:
C4703443
•
Finding
HPO: HP:0031618

Definition

Faint anterior chamber flare. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior chamber flare grade 1+

Professional guidelines

PubMed

Pars Plana Vitrectomy for the Treatment of Uveitis.
Henry CR, Becker MD, Yang Y, Davis JL
Am J Ophthalmol 2018 Jun;190:142-149. Epub 2018 Mar 28 doi: 10.1016/j.ajo.2018.03.031. PMID: 29601822
Mycophenolate mofetil monotherapy in the management of paediatric uveitis.
Chang PY, Giuliari GP, Shaikh M, Thakuria P, Makhoul D, Foster CS
Eye (Lond) 2011 Apr;25(4):427-35. Epub 2011 Mar 18 doi: 10.1038/eye.2011.23. PMID: 21423146Free PMC Article
Infliximab and etanercept in the treatment of chronic uveitis associated with refractory juvenile idiopathic arthritis.
Tynjälä P, Lindahl P, Honkanen V, Lahdenne P, Kotaniemi K
Ann Rheum Dis 2007 Apr;66(4):548-50. Epub 2006 Oct 26 doi: 10.1136/ard.2006.058248. PMID: 17068061Free PMC Article

Recent clinical studies

Etiology

Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis.
Miserocchi E, Giuffrè C, Cicinelli MV, Marchese A, Gattinara M, Modorati G, Bandello F
Eur J Ophthalmol 2020 Nov;30(6):1390-1396. Epub 2019 Dec 4 doi: 10.1177/1120672119892804. PMID: 31801359
Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Evaluation of Intraocular Inflammation with Laser Flare Photometry in Behçet Uveitis.
Yalcindag FN, Bingol Kiziltunc P, Savku E
Ocul Immunol Inflamm 2017 Feb;25(1):41-45. Epub 2016 Jan 30 doi: 10.3109/09273948.2015.1108444. PMID: 26828233
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302

Diagnosis

Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery.
Yalçınkaya Çakır G, Altan Ç, Çakır İ
Int Ophthalmol 2024 Feb 8;44(1):35. doi: 10.1007/s10792-024-02959-4. PMID: 38332452
Non-invasive Instrument-Based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review.
Liu X, McNally TW, Beese S, Downie LE, Solebo AL, Faes L, Husain S, Keane PA, Moore DJ, Denniston AK
Ocul Immunol Inflamm 2021 Jul 4;29(5):982-990. Epub 2020 Apr 7 doi: 10.1080/09273948.2019.1709650. PMID: 32255392
Evaluation of Intraocular Inflammation with Laser Flare Photometry in Behçet Uveitis.
Yalcindag FN, Bingol Kiziltunc P, Savku E
Ocul Immunol Inflamm 2017 Feb;25(1):41-45. Epub 2016 Jan 30 doi: 10.3109/09273948.2015.1108444. PMID: 26828233
Discrepancies in assessing anterior chamber activity among uveitis specialists.
Yeo TH, Ilangovan S, Keane PA, Pavesio C, Agrawal R
Jpn J Ophthalmol 2016 May;60(3):206-11. Epub 2016 Mar 28 doi: 10.1007/s10384-016-0438-0. PMID: 27020454
Laser flare-cell photometry: methodology and clinical applications.
Ladas JG, Wheeler NC, Morhun PJ, Rimmer SO, Holland GN
Surv Ophthalmol 2005 Jan-Feb;50(1):27-47. doi: 10.1016/j.survophthal.2004.10.004. PMID: 15621076

Therapy

Anterior chamber flare and choroidal vascular index as inflammatory markers after uncomplicated phacoemulsification surgery.
Yalçınkaya Çakır G, Altan Ç, Çakır İ
Int Ophthalmol 2024 Feb 8;44(1):35. doi: 10.1007/s10792-024-02959-4. PMID: 38332452
Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis.
Miserocchi E, Giuffrè C, Cicinelli MV, Marchese A, Gattinara M, Modorati G, Bandello F
Eur J Ophthalmol 2020 Nov;30(6):1390-1396. Epub 2019 Dec 4 doi: 10.1177/1120672119892804. PMID: 31801359
Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302

Prognosis

Incidence and Risk Factors of Recurrent Anterior Uveitis in Initial Acute-Onset Vogt-Koyanagi-Harada Disease.
Lim YJ, Byon I, Kim HW, Park SW, Kwon HJ, Kim E
Korean J Ophthalmol 2023 Aug;37(4):299-306. Epub 2023 Jul 3 doi: 10.3341/kjo.2023.0017. PMID: 37400085Free PMC Article
Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis.
Miserocchi E, Giuffrè C, Cicinelli MV, Marchese A, Gattinara M, Modorati G, Bandello F
Eur J Ophthalmol 2020 Nov;30(6):1390-1396. Epub 2019 Dec 4 doi: 10.1177/1120672119892804. PMID: 31801359
Comparative evaluation of femtosecond laser-assisted cataract surgery and conventional phacoemulsification in eyes with a shallow anterior chamber.
Vasavada VA, Vasavada S, Vasavada AR, Vasavada V, Srivastava S
J Cataract Refract Surg 2019 May;45(5):547-552. doi: 10.1016/j.jcrs.2018.11.037. PMID: 31030773
Ocular Hypotony in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis.
Böhm MR, Tappeiner C, Breitbach MA, Zurek-Imhoff B, Heinz C, Heiligenhaus A
Am J Ophthalmol 2017 Jan;173:45-55. Epub 2016 Sep 21 doi: 10.1016/j.ajo.2016.09.018. PMID: 27664701
Adalimumab in Patients with Active Noninfectious Uveitis.
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665

Clinical prediction guides

Switch from BAK-preserved to preservative-free latanoprost decreases anterior chamber flare in POAG patients.
Kestelyn PA, Kestelyn PG, De Bacquer D, Stevens AM
Int Ophthalmol 2019 Jan;39(1):105-109. Epub 2017 Dec 22 doi: 10.1007/s10792-017-0792-z. PMID: 29274019
Evaluation of Intraocular Inflammation with Laser Flare Photometry in Behçet Uveitis.
Yalcindag FN, Bingol Kiziltunc P, Savku E
Ocul Immunol Inflamm 2017 Feb;25(1):41-45. Epub 2016 Jan 30 doi: 10.3109/09273948.2015.1108444. PMID: 26828233
Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial.
Nguyen QD, Merrill PT, Jaffe GJ, Dick AD, Kurup SK, Sheppard J, Schlaen A, Pavesio C, Cimino L, Van Calster J, Camez AA, Kwatra NV, Song AP, Kron M, Tari S, Brézin AP
Lancet 2016 Sep 17;388(10050):1183-92. Epub 2016 Aug 16 doi: 10.1016/S0140-6736(16)31339-3. PMID: 27542302
A comparative study between clinical grading of anterior chamber flare and flare reading using the Kowa laser flare meter.
Konstantopoulou K, Del'Omo R, Morley AM, Karagiannis D, Bunce C, Pavesio C
Int Ophthalmol 2015 Oct;35(5):629-33. Epub 2012 Aug 2 doi: 10.1007/s10792-012-9616-3. PMID: 22855363
Efficacy and tolerability of preservative-free and preserved diclofenac and preserved ketorolac eyedrops after cataract surgery.
Maca SM, Amon M, Findl O, Kahraman G, Barisani-Asenbauer T
Am J Ophthalmol 2010 May;149(5):777-84. Epub 2010 Feb 11 doi: 10.1016/j.ajo.2009.12.010. PMID: 20152959

Recent systematic reviews

The Efficacy and Safety of Standard versus Soft Topical Steroids after Cataract Surgery: A Systematic Review and Meta-analysis.
Noyman DBE, Chan CC, Mimouni M, Safir M
Ophthalmology 2024 May;131(5):595-610. Epub 2023 Nov 23 doi: 10.1016/j.ophtha.2023.11.022. PMID: 38007198
Non-invasive Instrument-Based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review.
Liu X, McNally TW, Beese S, Downie LE, Solebo AL, Faes L, Husain S, Keane PA, Moore DJ, Denniston AK
Ocul Immunol Inflamm 2021 Jul 4;29(5):982-990. Epub 2020 Apr 7 doi: 10.1080/09273948.2019.1709650. PMID: 32255392
Difluprednate versus Prednisolone Acetate after Cataract Surgery: a Systematic Review and Meta-Analysis.
KhalafAllah MT, Basiony A, Salama A
BMJ Open 2019 Nov 2;9(11):e026752. doi: 10.1136/bmjopen-2018-026752. PMID: 31678934Free PMC Article
Pars Plana Vitrectomy for the Treatment of Uveitis.
Henry CR, Becker MD, Yang Y, Davis JL
Am J Ophthalmol 2018 Jun;190:142-149. Epub 2018 Mar 28 doi: 10.1016/j.ajo.2018.03.031. PMID: 29601822
Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery.
Juthani VV, Clearfield E, Chuck RS
Cochrane Database Syst Rev 2017 Jul 3;7(7):CD010516. doi: 10.1002/14651858.CD010516.pub2. PMID: 28670710Free PMC Article

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