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Refractory Glioma

MedGen UID:
1633847
•Concept ID:
C4687707
•
Neoplastic Process

Definition

Glioma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Treatment of Pediatric Low-Grade Gliomas.
Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
EANO guidelines for the diagnosis and treatment of meningiomas.
Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, von Deimling A, Stavrinou P, Lefranc F, Lund-Johansen M, Moyal EC, Brandsma D, Henriksson R, Soffietti R, Weller M
Lancet Oncol 2016 Sep;17(9):e383-91. Epub 2016 Aug 30 doi: 10.1016/S1470-2045(16)30321-7. PMID: 27599143
Blood-brain barrier and chemotherapeutic treatment of brain tumors.
de Vries NA, Beijnen JH, Boogerd W, van Tellingen O
Expert Rev Neurother 2006 Aug;6(8):1199-209. doi: 10.1586/14737175.6.8.1199. PMID: 16893347

Recent clinical studies

Etiology

A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01.
Perreault S, Larouche V, Tabori U, Hawkin C, Lippé S, Ellezam B, Décarie JC, Théoret Y, Métras MÉ, Sultan S, Cantin É, Routhier MÈ, Caru M, Legault G, Bouffet É, Lafay-Cousin L, Hukin J, Erker C, Jabado N
BMC Cancer 2019 Dec 27;19(1):1250. doi: 10.1186/s12885-019-6442-2. PMID: 31881853Free PMC Article
miR‑342 inhibits glioma cell proliferation by targeting GPRC5A.
Wang J, Yang Y, Cao Y, Tang X
Mol Med Rep 2019 Jul;20(1):252-260. Epub 2019 May 15 doi: 10.3892/mmr.2019.10242. PMID: 31115523Free PMC Article
An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma.
Arafat WO, Buchsbaum DJ, Gómez-Navarro J, Tawil SA, Olsen C, Xiang J, El-Akad H, Salama AM, Badib AO, Stackhouse MA, Curiel DT
Int J Radiat Oncol Biol Phys 2003 Mar 15;55(4):1037-50. doi: 10.1016/s0360-3016(02)04488-7. PMID: 12605984

Therapy

A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma.
Lopez J, Lai-Kwon J, Molife R, Welsh L, Tunariu N, Roda D, Fernández-García P, Lladó V, McNicholl AG, Rosselló CA, Taylor RJ, Azaro A, Rodón J, Sludden J, Veal GJ, Plummer R, Urruticoechea A, Lahuerta A, Mujika K, Escribá PV
Br J Cancer 2023 Sep;129(5):811-818. Epub 2023 Jul 24 doi: 10.1038/s41416-023-02356-1. PMID: 37488446Free PMC Article
A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01.
Perreault S, Larouche V, Tabori U, Hawkin C, Lippé S, Ellezam B, Décarie JC, Théoret Y, Métras MÉ, Sultan S, Cantin É, Routhier MÈ, Caru M, Legault G, Bouffet É, Lafay-Cousin L, Hukin J, Erker C, Jabado N
BMC Cancer 2019 Dec 27;19(1):1250. doi: 10.1186/s12885-019-6442-2. PMID: 31881853Free PMC Article
The synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines is accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels.
Lu XY, Cao K, Li QY, Yuan ZC, Lu PS
J Int Med Res 2012;40(3):995-1004. doi: 10.1177/147323001204000318. PMID: 22906272
An adenovirus encoding proapoptotic Bax synergistically radiosensitizes malignant glioma.
Arafat WO, Buchsbaum DJ, Gómez-Navarro J, Tawil SA, Olsen C, Xiang J, El-Akad H, Salama AM, Badib AO, Stackhouse MA, Curiel DT
Int J Radiat Oncol Biol Phys 2003 Mar 15;55(4):1037-50. doi: 10.1016/s0360-3016(02)04488-7. PMID: 12605984

Prognosis

miR‑342 inhibits glioma cell proliferation by targeting GPRC5A.
Wang J, Yang Y, Cao Y, Tang X
Mol Med Rep 2019 Jul;20(1):252-260. Epub 2019 May 15 doi: 10.3892/mmr.2019.10242. PMID: 31115523Free PMC Article

Clinical prediction guides

A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01.
Perreault S, Larouche V, Tabori U, Hawkin C, Lippé S, Ellezam B, Décarie JC, Théoret Y, Métras MÉ, Sultan S, Cantin É, Routhier MÈ, Caru M, Legault G, Bouffet É, Lafay-Cousin L, Hukin J, Erker C, Jabado N
BMC Cancer 2019 Dec 27;19(1):1250. doi: 10.1186/s12885-019-6442-2. PMID: 31881853Free PMC Article

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    Practice guidelines

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