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Malignant Pericarditis

MedGen UID:
163427
•Concept ID:
C0852945
•
Disease or Syndrome
Synonym: Pericarditis, Malignant

Definition

Pericarditis caused by the infiltration of the pericardium by a malignant neoplasm. The diagnosis is based on the cytological examination of pericardial fluid or the histologic examination of pericardial tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Pericarditis

Professional guidelines

PubMed

Management of Lung Cancer-Associated Malignant Pericardial Effusion with Intrapericardial Administration of Carboplatin: A Retrospective Study.
Imai H, Kaira K, Masubuchi K, Minato K
Curr Oncol 2021 Dec 30;29(1):163-172. doi: 10.3390/curroncol29010015. PMID: 35049689Free PMC Article
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study.
Kotake M, Imai H, Kaira K, Fujisawa T, Yanagita Y, Minato K
Cancer Chemother Pharmacol 2019 Sep;84(3):655-660. Epub 2019 Jun 27 doi: 10.1007/s00280-019-03897-0. PMID: 31250155Free PMC Article

Recent clinical studies

Etiology

In-hospital adverse events and recurrence in hospitalized patients with acute pericarditis.
Aikawa H, Fujino M, Murai K, Iwai T, Sawada K, Matama H, Miura H, Honda S, Yoneda S, Takagi K, Otsuka F, Kataoka Y, Asaumi Y, Tahara Y, Ogata S, Nishimura K, Tsujita K, Noguchi T
J Cardiol 2023 Oct;82(4):268-273. Epub 2023 Mar 9 doi: 10.1016/j.jjcc.2023.03.002. PMID: 36906259
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study.
Kotake M, Imai H, Kaira K, Fujisawa T, Yanagita Y, Minato K
Cancer Chemother Pharmacol 2019 Sep;84(3):655-660. Epub 2019 Jun 27 doi: 10.1007/s00280-019-03897-0. PMID: 31250155Free PMC Article
Characteristics of Pericardial Biopsy: 100 Cases in a Single Center.
Fallek Boldes O, Dahan S, Segal Y, Ben-Ami Shor D, Huber RK, Barshack I, Horowitz Y, Segal G, Dagan A
Isr Med Assoc J 2019 Mar;21(3):183-188. PMID: 30905104
Diagnosis of malignant pericarditis: a single centre experience.
Pawlak Cieślik A, Szturmowicz M, Fijałkowska A, Gątarek J, Gralec R, Błasińska-Przerwa K, Szczepulska-Wójcik E, Skoczylas A, Bilska A, Tomkowski W
Kardiol Pol 2012;70(11):1147-53. PMID: 23180523
Patient with bilateral pleural effusion: are the findings the same in each fluid?
Kalomenidis I, Rodriguez M, Barnette R, Gupta R, Hawthorne M, Parkes KB, Light RW
Chest 2003 Jul;124(1):167-76. doi: 10.1378/chest.124.1.167. PMID: 12853520

Diagnosis

Characteristics of Pericardial Biopsy: 100 Cases in a Single Center.
Fallek Boldes O, Dahan S, Segal Y, Ben-Ami Shor D, Huber RK, Barshack I, Horowitz Y, Segal G, Dagan A
Isr Med Assoc J 2019 Mar;21(3):183-188. PMID: 30905104
Recurrent cervical cancer presenting as malignant pericarditis: case report and review of the literature.
Verleye L, Thomakos N, Edmondson RJ
Eur J Gynaecol Oncol 2009;30(2):193-5. PMID: 19480253
Patient with bilateral pleural effusion: are the findings the same in each fluid?
Kalomenidis I, Rodriguez M, Barnette R, Gupta R, Hawthorne M, Parkes KB, Light RW
Chest 2003 Jul;124(1):167-76. doi: 10.1378/chest.124.1.167. PMID: 12853520
The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis.
Szturmowicz M, Tomkowski W, Fijalkowska A, Burakowski J, Sakowicz A, Filipecki S
Int J Biol Markers 1997 Jul-Sep;12(3):96-101. doi: 10.1177/172460089701200302. PMID: 9479590
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis.
Koh KK, Kim EJ, Cho CH, Choi MJ, Cho SK, Kim SS, Kim MH, Lee CJ, Jin SH, Kim JM
Circulation 1994 Jun;89(6):2728-35. doi: 10.1161/01.cir.89.6.2728. PMID: 8205688

Therapy

Successful Management of Malignant Pericarditis Using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma.
Uneno Y, Nomura M, Hosokai T, Kurakake Y, Fuki M, Shiomi H, Takeuchi Y, Tamaoki M, Yokoyama A, Katada C, Muto M
Intern Med 2024 Mar 1;63(5):677-680. Epub 2023 Jul 19 doi: 10.2169/internalmedicine.2041-23. PMID: 37468243Free PMC Article
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study.
Kotake M, Imai H, Kaira K, Fujisawa T, Yanagita Y, Minato K
Cancer Chemother Pharmacol 2019 Sep;84(3):655-660. Epub 2019 Jun 27 doi: 10.1007/s00280-019-03897-0. PMID: 31250155Free PMC Article
Direct pericardial involvement of non-small cell lung cancer rapidly developing pericardial constriction.
Wakamatsu T, Koizumi T, Urushihata K, Fujimoto K, Uchikawa S, Kubo K, Iwamura A, Yazawa M
Jpn J Clin Oncol 2004 Oct;34(10):627-9. doi: 10.1093/jjco/hyh109. PMID: 15591462
Controlling malignant pericardial effusion by intrapericardial carboplatin administration in patients with primary non-small-cell lung cancer.
Moriya T, Takiguchi Y, Tabeta H, Watanabe R, Kimura H, Nagao K, Kuriyama T
Br J Cancer 2000 Oct;83(7):858-62. doi: 10.1054/bjoc.2000.1397. PMID: 10970685Free PMC Article

Prognosis

Successful Management of Malignant Pericarditis Using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma.
Uneno Y, Nomura M, Hosokai T, Kurakake Y, Fuki M, Shiomi H, Takeuchi Y, Tamaoki M, Yokoyama A, Katada C, Muto M
Intern Med 2024 Mar 1;63(5):677-680. Epub 2023 Jul 19 doi: 10.2169/internalmedicine.2041-23. PMID: 37468243Free PMC Article
In-hospital adverse events and recurrence in hospitalized patients with acute pericarditis.
Aikawa H, Fujino M, Murai K, Iwai T, Sawada K, Matama H, Miura H, Honda S, Yoneda S, Takagi K, Otsuka F, Kataoka Y, Asaumi Y, Tahara Y, Ogata S, Nishimura K, Tsujita K, Noguchi T
J Cardiol 2023 Oct;82(4):268-273. Epub 2023 Mar 9 doi: 10.1016/j.jjcc.2023.03.002. PMID: 36906259
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study.
Kotake M, Imai H, Kaira K, Fujisawa T, Yanagita Y, Minato K
Cancer Chemother Pharmacol 2019 Sep;84(3):655-660. Epub 2019 Jun 27 doi: 10.1007/s00280-019-03897-0. PMID: 31250155Free PMC Article
Characteristics of Pericardial Biopsy: 100 Cases in a Single Center.
Fallek Boldes O, Dahan S, Segal Y, Ben-Ami Shor D, Huber RK, Barshack I, Horowitz Y, Segal G, Dagan A
Isr Med Assoc J 2019 Mar;21(3):183-188. PMID: 30905104
Diagnosis of malignant pericarditis: a single centre experience.
Pawlak Cieślik A, Szturmowicz M, Fijałkowska A, Gątarek J, Gralec R, Błasińska-Przerwa K, Szczepulska-Wójcik E, Skoczylas A, Bilska A, Tomkowski W
Kardiol Pol 2012;70(11):1147-53. PMID: 23180523

Clinical prediction guides

In-hospital adverse events and recurrence in hospitalized patients with acute pericarditis.
Aikawa H, Fujino M, Murai K, Iwai T, Sawada K, Matama H, Miura H, Honda S, Yoneda S, Takagi K, Otsuka F, Kataoka Y, Asaumi Y, Tahara Y, Ogata S, Nishimura K, Tsujita K, Noguchi T
J Cardiol 2023 Oct;82(4):268-273. Epub 2023 Mar 9 doi: 10.1016/j.jjcc.2023.03.002. PMID: 36906259
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study.
Kotake M, Imai H, Kaira K, Fujisawa T, Yanagita Y, Minato K
Cancer Chemother Pharmacol 2019 Sep;84(3):655-660. Epub 2019 Jun 27 doi: 10.1007/s00280-019-03897-0. PMID: 31250155Free PMC Article
Diagnosis of malignant pericarditis: a single centre experience.
Pawlak Cieślik A, Szturmowicz M, Fijałkowska A, Gątarek J, Gralec R, Błasińska-Przerwa K, Szczepulska-Wójcik E, Skoczylas A, Bilska A, Tomkowski W
Kardiol Pol 2012;70(11):1147-53. PMID: 23180523
Characterization of IL-2-activated TILs and their use in intrapericardial immunotherapy in malignant pericardial effusion.
Toh U, Fujii T, Seki N, Niiya F, Shirouzu K, Yamana H
Cancer Immunol Immunother 2006 Oct;55(10):1219-27. Epub 2005 Dec 16 doi: 10.1007/s00262-005-0112-8. PMID: 16362409Free PMC Article
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis.
Koh KK, Kim EJ, Cho CH, Choi MJ, Cho SK, Kim SS, Kim MH, Lee CJ, Jin SH, Kim JM
Circulation 1994 Jun;89(6):2728-35. doi: 10.1161/01.cir.89.6.2728. PMID: 8205688

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