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Intraretinal hemorrhage

MedGen UID:
1635066
•Concept ID:
C4551659
•
Disease or Syndrome
Synonym: Intraretinal haemorrhage
SNOMED CT: Intraretinal hemorrhage (28998008)
 
HPO: HP:0031805

Definition

A subtype of fundus hemorrhage occurring within the neurosensory retina. Intraretinal hemorrhages may be 'dot' or' blot' shaped or flame shaped depending upon their depth within the retina. [from HPO]

Professional guidelines

PubMed

Cytomegalovirus Retinitis: Clinical Manifestations, Diagnosis and Treatment.
Zhang J, Kamoi K, Zong Y, Yang M, Zou Y, Miyagaki M, Ohno-Matsui K
Viruses 2024 Sep 7;16(9) doi: 10.3390/v16091427. PMID: 39339903Free PMC Article
Eyes With Acute, Treatment-Naïve CRVO and Foveal Intraretinal Hemorrhage: Characteristics and Outcomes.
Mir TA, Thomas AS, Yoon SP, Birnbaum F, Goerlitz-Jessen M, Fekrat S
Ophthalmic Surg Lasers Imaging Retina 2019 Dec 1;50(12):752-759. doi: 10.3928/23258160-20191119-02. PMID: 31877220
The retinal disease screening study: retrospective comparison of nonmydriatic fundus photography and three-dimensional optical coherence tomography for detection of retinal irregularities.
Ouyang Y, Heussen FM, Keane PA, Sadda SR, Walsh AC
Invest Ophthalmol Vis Sci 2013 Aug 21;54(8):5694-700. doi: 10.1167/iovs.13-12043. PMID: 23847317

Recent clinical studies

Etiology

Clinical features of retinopathy after cardiopulmonary resuscitation.
Park SH, Kim SY, Park SW, Byon I, Lee SM
BMC Ophthalmol 2023 Sep 21;23(1):386. doi: 10.1186/s12886-023-03137-3. PMID: 37735637Free PMC Article
Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm.
Kim JH, Kim JW, Kim CG, Lew YJ, Cho HJ
Sci Rep 2021 Jul 9;11(1):14246. doi: 10.1038/s41598-021-93811-7. PMID: 34244580Free PMC Article
ADVERSE EFFECT OF MACULAR INTRARETINAL HEMORRHAGE ON THE PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE.
Doi S, Kimura S, Morizane Y, Hosokawa MM, Shiode Y, Hirano M, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Okanouchi T, Inoue Y, Shiraga F
Retina 2020 May;40(5):989-997. doi: 10.1097/IAE.0000000000002460. PMID: 30649079
Eyes With Acute, Treatment-Naïve CRVO and Foveal Intraretinal Hemorrhage: Characteristics and Outcomes.
Mir TA, Thomas AS, Yoon SP, Birnbaum F, Goerlitz-Jessen M, Fekrat S
Ophthalmic Surg Lasers Imaging Retina 2019 Dec 1;50(12):752-759. doi: 10.3928/23258160-20191119-02. PMID: 31877220
Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography.
Munk MR, Dunavoelgyi R, Baratsits M, Matt G, Montuoro A, Buehl W, Schmidt-Erfurth U, Sacu S; Macula Study Group
Curr Eye Res 2015;40(10):1046-54. Epub 2014 Oct 20 doi: 10.3109/02713683.2014.971931. PMID: 25329527

Diagnosis

Cytomegalovirus Retinitis: Clinical Manifestations, Diagnosis and Treatment.
Zhang J, Kamoi K, Zong Y, Yang M, Zou Y, Miyagaki M, Ohno-Matsui K
Viruses 2024 Sep 7;16(9) doi: 10.3390/v16091427. PMID: 39339903Free PMC Article
Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography.
Munk MR, Dunavoelgyi R, Baratsits M, Matt G, Montuoro A, Buehl W, Schmidt-Erfurth U, Sacu S; Macula Study Group
Curr Eye Res 2015;40(10):1046-54. Epub 2014 Oct 20 doi: 10.3109/02713683.2014.971931. PMID: 25329527
Ocular involvement of brucellosis.
Bazzazi N, Yavarikia A, Keramat F
Middle East Afr J Ophthalmol 2013 Jan-Mar;20(1):95-7. doi: 10.4103/0974-9233.106407. PMID: 23580863Free PMC Article
Subacute sclerosing panencephalitis.
Gravina RF, Nakanishi AS, Faden A
Am J Ophthalmol 1978 Jul;86(1):106-9. doi: 10.1016/0002-9394(78)90024-7. PMID: 677221
Retinal macroaneurysms.
Asdourian GK, Goldberg MF, Jampol L, Rabb M
Arch Ophthalmol 1977 Apr;95(4):624-8. doi: 10.1001/archopht.1977.04450040090013. PMID: 557969

Therapy

Cytomegalovirus Retinitis: Clinical Manifestations, Diagnosis and Treatment.
Zhang J, Kamoi K, Zong Y, Yang M, Zou Y, Miyagaki M, Ohno-Matsui K
Viruses 2024 Sep 7;16(9) doi: 10.3390/v16091427. PMID: 39339903Free PMC Article
Clinical features of retinopathy after cardiopulmonary resuscitation.
Park SH, Kim SY, Park SW, Byon I, Lee SM
BMC Ophthalmol 2023 Sep 21;23(1):386. doi: 10.1186/s12886-023-03137-3. PMID: 37735637Free PMC Article
Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm.
Kim JH, Kim JW, Kim CG, Lew YJ, Cho HJ
Sci Rep 2021 Jul 9;11(1):14246. doi: 10.1038/s41598-021-93811-7. PMID: 34244580Free PMC Article
Eyes With Acute, Treatment-Naïve CRVO and Foveal Intraretinal Hemorrhage: Characteristics and Outcomes.
Mir TA, Thomas AS, Yoon SP, Birnbaum F, Goerlitz-Jessen M, Fekrat S
Ophthalmic Surg Lasers Imaging Retina 2019 Dec 1;50(12):752-759. doi: 10.3928/23258160-20191119-02. PMID: 31877220
Ocular involvement of brucellosis.
Bazzazi N, Yavarikia A, Keramat F
Middle East Afr J Ophthalmol 2013 Jan-Mar;20(1):95-7. doi: 10.4103/0974-9233.106407. PMID: 23580863Free PMC Article

Prognosis

IMPACT OF MACULAR INTRARETINAL HEMORRHAGE AND MACULAR HOLE ON THE VISUAL PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE.
Doi S, Kimura S, Saito S, Inoue M, Sakurai T, Kobori A, Hisatomi T, Imai H, Kuriyama S, Takasu I, Hosokawa MM, Shiode Y, Matoba R, Suzuki E, Morizane Y
Retina 2023 Apr 1;43(4):585-593. doi: 10.1097/IAE.0000000000003725. PMID: 36735920
Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm.
Kim JH, Kim JW, Kim CG, Lew YJ, Cho HJ
Sci Rep 2021 Jul 9;11(1):14246. doi: 10.1038/s41598-021-93811-7. PMID: 34244580Free PMC Article
Vitreous and Chorioretinal Lesions in People Who Inject Drugs and Are Hospitalized with Bloodstream and Related Infections.
Greven MA, Weinstein JE, Tsamis KA, Vadala SA, Barnes EW, Peacock JE Jr
Ophthalmol Retina 2021 Dec;5(12):1263-1268. Epub 2021 Mar 3 doi: 10.1016/j.oret.2021.02.018. PMID: 33667700
SCORE2 Report 13: Intraretinal Hemorrhage Changes in Eyes With Central or Hemiretinal Vein Occlusion Managed With Aflibercept, Bevacizumab or Observation. Secondary Analysis of the SCORE and SCORE2 Clinical Trials.
Hendrick A, VanVeldhuisen PC, Scott IU, King J, Blodi BA, Ip MS, Khurana RN, Oden NL; SCORE2 Investigator Group
Am J Ophthalmol 2021 Feb;222:185-193. Epub 2020 Aug 20 doi: 10.1016/j.ajo.2020.08.030. PMID: 32828880Free PMC Article
ADVERSE EFFECT OF MACULAR INTRARETINAL HEMORRHAGE ON THE PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE.
Doi S, Kimura S, Morizane Y, Hosokawa MM, Shiode Y, Hirano M, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Okanouchi T, Inoue Y, Shiraga F
Retina 2020 May;40(5):989-997. doi: 10.1097/IAE.0000000000002460. PMID: 30649079

Clinical prediction guides

Clinical features of retinopathy after cardiopulmonary resuscitation.
Park SH, Kim SY, Park SW, Byon I, Lee SM
BMC Ophthalmol 2023 Sep 21;23(1):386. doi: 10.1186/s12886-023-03137-3. PMID: 37735637Free PMC Article
Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm.
Kim JH, Kim JW, Kim CG, Lew YJ, Cho HJ
Sci Rep 2021 Jul 9;11(1):14246. doi: 10.1038/s41598-021-93811-7. PMID: 34244580Free PMC Article
ADVERSE EFFECT OF MACULAR INTRARETINAL HEMORRHAGE ON THE PROGNOSIS OF SUBMACULAR HEMORRHAGE DUE TO RETINAL ARTERIAL MACROANEURYSM RUPTURE.
Doi S, Kimura S, Morizane Y, Hosokawa MM, Shiode Y, Hirano M, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Okanouchi T, Inoue Y, Shiraga F
Retina 2020 May;40(5):989-997. doi: 10.1097/IAE.0000000000002460. PMID: 30649079
Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography.
Munk MR, Dunavoelgyi R, Baratsits M, Matt G, Montuoro A, Buehl W, Schmidt-Erfurth U, Sacu S; Macula Study Group
Curr Eye Res 2015;40(10):1046-54. Epub 2014 Oct 20 doi: 10.3109/02713683.2014.971931. PMID: 25329527
Retinal macroaneurysms.
Asdourian GK, Goldberg MF, Jampol L, Rabb M
Arch Ophthalmol 1977 Apr;95(4):624-8. doi: 10.1001/archopht.1977.04450040090013. PMID: 557969

Recent systematic reviews

A systematic review of the diagnostic accuracy of ocular signs in pediatric abusive head trauma.
Bhardwaj G, Chowdhury V, Jacobs MB, Moran KT, Martin FJ, Coroneo MT
Ophthalmology 2010 May;117(5):983-992.e17. Epub 2010 Mar 27 doi: 10.1016/j.ophtha.2009.09.040. PMID: 20347153

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