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Cardiac Yolk Sac Tumor

MedGen UID:
1643931
•Concept ID:
C4687641
•
Neoplastic Process
Synonym: Heart Yolk Sac Tumor

Definition

A yolk sac tumor that arises within the myocardium or cardiac chambers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiac Yolk Sac Tumor

Recent clinical studies

Etiology

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Multimodal imaging changed clinical decision-making: A rare mediastinal yolk sac tumor infiltrating the heart and follow-up.
Yang Q, Liu H, Liu Y
Echocardiography 2021 Sep;38(9):1662-1665. Epub 2021 Aug 25 doi: 10.1111/echo.15180. PMID: 34435391
Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors.
Al-Hogbani M, Duguay J, Wagner DC, Haferkamp A, Joubert P, Frees S, Rendon R, Power N, Périgny M, Toren P
Urol Oncol 2021 May;39(5):303.e1-303.e8. Epub 2021 Mar 5 doi: 10.1016/j.urolonc.2021.02.014. PMID: 33685799
Imaging in gynecological disease (17): ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors).
Anfelter P, Testa A, Chiappa V, Froyman W, Fruscio R, Guerriero S, Alcazar JL, Mascillini F, Pascual MA, Sibal M, Savelli L, Zannoni GF, Timmerman D, Epstein E
Ultrasound Obstet Gynecol 2020 Aug;56(2):276-284. doi: 10.1002/uog.22002. PMID: 32119168
Right Ventricular Heart Failure from a Cardiac Yolk Sac Tumor.
Isom N, Rali AS, Damjanov I, Hubbard K, Grigsby J, Gupta K
Am J Case Rep 2018 Mar 2;19:229-233. doi: 10.12659/ajcr.907639. PMID: 29497026Free PMC Article

Diagnosis

An unexpected intracardiac location of yolk sac tumor.
Sel K, Alehan D, Yalçin B, Önder SÇ, Aykan HH, Akyüz C, Doğan R
Cardiovasc Pathol 2023 Jan-Feb;62:107480. Epub 2022 Sep 30 doi: 10.1016/j.carpath.2022.107480. PMID: 36183854
Mediastinal yolk sac tumor infiltrating the heart.
Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
Images in cardiology: Pericardial yolk sac tumor presenting as cardiac tamponade in a 21-month-old child.
Chintala K, Bloom DA, Walters HL 3rd, Pettersen MD
Clin Cardiol 2004 Jul;27(7):411. doi: 10.1002/clc.4960270709. PMID: 15298042Free PMC Article
CD105 is important for angiogenesis: evidence and potential applications.
Duff SE, Li C, Garland JM, Kumar S
FASEB J 2003 Jun;17(9):984-92. doi: 10.1096/fj.02-0634rev. PMID: 12773481
Recurrent arterial embolization from a metastatic germ cell tumor invading the left atrium.
Singh A, Jenkins DP, Dahdal M, Dhar S, Ratnatunga CP
Ann Thorac Surg 2000 Dec;70(6):2155-6. doi: 10.1016/s0003-4975(00)01899-3. PMID: 11156144

Therapy

In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliatus ICN25 in zebrafish embryos.
Iniyan AM, Kannan RR, Joseph FRS, Mary TRJ, Rajasekar M, Sumy PC, Rabel AM, Ramachandran D, Vincent SGP
Microb Pathog 2017 Nov;112:76-82. Epub 2017 Sep 21 doi: 10.1016/j.micpath.2017.07.054. PMID: 28943148
CD105 is important for angiogenesis: evidence and potential applications.
Duff SE, Li C, Garland JM, Kumar S
FASEB J 2003 Jun;17(9):984-92. doi: 10.1096/fj.02-0634rev. PMID: 12773481
Stage IV malignant intrapericardial germ cell tumor: a case report.
Bath LE, Walayat M, Mankad P, Godman MJ, Wallace WH
Pediatr Hematol Oncol 1997 Sep-Oct;14(5):451-5. doi: 10.3109/08880019709028775. PMID: 9267877
Endodermal sinus (yolk sac) tumor in infants and children. A clinical and pathologic study: an 11 year review.
Shebib S, Sabbah RS, Sackey K, Akhtar M, Aur RJ
Am J Pediatr Hematol Oncol 1989 Spring;11(1):36-9. doi: 10.1097/00043426-198921000-00009. PMID: 2712240
Intrapericardial yolk sac tumor in an infant girl.
Nelson E, Stenzel P
Cancer 1987 Oct 1;60(7):1567-9. doi: 10.1002/1097-0142(19871001)60:7<1567::aid-cncr2820600726>3.0.co;2-a. PMID: 2441845

Prognosis

Multimodal imaging changed clinical decision-making: A rare mediastinal yolk sac tumor infiltrating the heart and follow-up.
Yang Q, Liu H, Liu Y
Echocardiography 2021 Sep;38(9):1662-1665. Epub 2021 Aug 25 doi: 10.1111/echo.15180. PMID: 34435391
Mediastinal yolk sac tumor infiltrating the heart.
Imaniar R, Syahruddin E, Soepandi PZ, Putra AC, Nurwidya F
Exp Oncol 2018 Mar;40(1):82-84. PMID: 29600980
Right Ventricular Heart Failure from a Cardiac Yolk Sac Tumor.
Isom N, Rali AS, Damjanov I, Hubbard K, Grigsby J, Gupta K
Am J Case Rep 2018 Mar 2;19:229-233. doi: 10.12659/ajcr.907639. PMID: 29497026Free PMC Article
CD105 is important for angiogenesis: evidence and potential applications.
Duff SE, Li C, Garland JM, Kumar S
FASEB J 2003 Jun;17(9):984-92. doi: 10.1096/fj.02-0634rev. PMID: 12773481
Primary intracardiac yolk sac tumor.
Parvathy U, Balakrishnan KR, Ranjit MS, Kuruvilla S, Rao KR
Pediatr Cardiol 1998 Nov-Dec;19(6):495-7. doi: 10.1007/s002469900368. PMID: 9770582

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
An unexpected intracardiac location of yolk sac tumor.
Sel K, Alehan D, Yalçin B, Önder SÇ, Aykan HH, Akyüz C, Doğan R
Cardiovasc Pathol 2023 Jan-Feb;62:107480. Epub 2022 Sep 30 doi: 10.1016/j.carpath.2022.107480. PMID: 36183854
Anti-Tumor Active Isopropylated Fused Azaisocytosine-Containing Congeners Are Safe for Developing Danio rerio as Well as Red Blood Cells and Activate Apoptotic Caspases in Human Breast Carcinoma Cells.
Sztanke M, Rzymowska J, Sztanke K
Molecules 2022 Feb 11;27(4) doi: 10.3390/molecules27041211. PMID: 35209001Free PMC Article
Expression of programmed death ligand-1 (PD-L1) in metastatic and postchemotherapy viable testicular germ cell tumors.
Al-Hogbani M, Duguay J, Wagner DC, Haferkamp A, Joubert P, Frees S, Rendon R, Power N, Périgny M, Toren P
Urol Oncol 2021 May;39(5):303.e1-303.e8. Epub 2021 Mar 5 doi: 10.1016/j.urolonc.2021.02.014. PMID: 33685799
Imaging in gynecological disease (17): ultrasound features of malignant ovarian yolk sac tumors (endodermal sinus tumors).
Anfelter P, Testa A, Chiappa V, Froyman W, Fruscio R, Guerriero S, Alcazar JL, Mascillini F, Pascual MA, Sibal M, Savelli L, Zannoni GF, Timmerman D, Epstein E
Ultrasound Obstet Gynecol 2020 Aug;56(2):276-284. doi: 10.1002/uog.22002. PMID: 32119168

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