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Locally Advanced Soft Tissue Sarcoma

MedGen UID:
1648947
Concept ID:
C4727772
Neoplastic Process

Definition

Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063

Recent clinical studies

Etiology

Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong A, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco B, Herraez AC, Gronchi A, Mangel L, Sy-Ortin T, Hohenberger P, de Baère T, Le Cesne A, Helfre S, Saada-Bouzid E, Borkowska A, Anghel R, Co A, Gebhart M, Kantor G, Montero A, Loong HH, Vergés R, Lapeire L, Dema S, Kacso G, Austen L, Moureau-Zabotto L, Servois V, Wardelmann E, Terrier P, Lazar AJ, Bovée JVMG, Le Péchoux C, Papai Z
Lancet Oncol 2019 Aug;20(8):1148-1159. Epub 2019 Jul 8 doi: 10.1016/S1470-2045(19)30326-2. PMID: 31296491
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063

Diagnosis

Bonvalot S, Wunder J, Gronchi A, Broto JM, Turcotte R, Rastrelli M, Papai Z, Radaelli S, Lindner LH, Shumelinsky F, Cubillo A, Rutkowski P, Demaire C, Strens D, Nalbantov G
Eur J Surg Oncol 2021 Aug;47(8):2166-2172. Epub 2021 Feb 26 doi: 10.1016/j.ejso.2021.02.024. PMID: 33676792
Villalobos VM, Mo G, Agulnik M, Pollack SM, Rushing DA, Singh A, Van Tine BA, McNaughton R, Decker RL, Zhang W, Shahir A, Cronier DM
Cancer Med 2020 Feb;9(3):882-893. Epub 2019 Dec 10 doi: 10.1002/cam4.2728. PMID: 31821732Free PMC Article
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
van Ginkel RJ, Kole AC, Nieweg OE, Molenaar WM, Pruim J, Koops HS, Vaalburg W, Hoekstra HJ
J Nucl Med 1999 Feb;40(2):262-7. PMID: 10025833
Olieman AF, van Ginkel RJ, Hoekstra HJ, Mooyaart EL, Molenaar WM, Koops HS
Ann Surg Oncol 1997 Jan;4(1):64-9. doi: 10.1007/BF02316812. PMID: 8985519

Therapy

Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong AM, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco BJ, Herráez AC, Gronchi A, Sy-Ortin T, Hohenberger P, de Baère T, Cesne AL, Helfre S, Saada-Bouzid E, Anghel RM, Kantor G, Montero A, Loong HH, Vergés R, Kacso G, Austen L, Servois VF, Wardelmann E, Dimitriu M, Said P, Lazar AJ, Bovée JVMG, Péchoux CL, Pápai Z
Int J Radiat Oncol Biol Phys 2022 Nov 1;114(3):422-432. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.001. PMID: 35850363
Espenel S, Chargari C, Blanchard P, Bockel S, Morel D, Rivera S, Levy A, Deutsch E
Eur J Cancer 2022 Aug;171:242-258. Epub 2022 Jun 29 doi: 10.1016/j.ejca.2022.04.038. PMID: 35779346
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong A, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco B, Herraez AC, Gronchi A, Mangel L, Sy-Ortin T, Hohenberger P, de Baère T, Le Cesne A, Helfre S, Saada-Bouzid E, Borkowska A, Anghel R, Co A, Gebhart M, Kantor G, Montero A, Loong HH, Vergés R, Lapeire L, Dema S, Kacso G, Austen L, Moureau-Zabotto L, Servois V, Wardelmann E, Terrier P, Lazar AJ, Bovée JVMG, Le Péchoux C, Papai Z
Lancet Oncol 2019 Aug;20(8):1148-1159. Epub 2019 Jul 8 doi: 10.1016/S1470-2045(19)30326-2. PMID: 31296491
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063

Prognosis

Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Wang CM, Zhang R, Luo P, Wu Z, Zheng B, Chen Y, Shi Y
J Surg Oncol 2018 Feb;117(2):130-136. Epub 2017 Oct 26 doi: 10.1002/jso.24823. PMID: 29073726
Rossi CR, Mocellin S, Pilati P, Foletto M, Quintieri L, Palatini P, Lise M
Surg Oncol Clin N Am 2003 Jul;12(3):781-94. doi: 10.1016/s1055-3207(03)00030-9. PMID: 14567031

Clinical prediction guides

Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Monga V, Miller BJ, Tanas M, Boukhar S, Allen B, Anderson C, Stephens L, Hartwig S, Varga S, Houtman J, Wang L, Zhang W, Jaber O, Thomason J, Kuehn D, Rajput M, Metz C, Zamba KD, Mott S, Abanonu C, Bhatia S, Milhem M
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-003119. PMID: 34330766Free PMC Article
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong A, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco B, Herraez AC, Gronchi A, Mangel L, Sy-Ortin T, Hohenberger P, de Baère T, Le Cesne A, Helfre S, Saada-Bouzid E, Borkowska A, Anghel R, Co A, Gebhart M, Kantor G, Montero A, Loong HH, Vergés R, Lapeire L, Dema S, Kacso G, Austen L, Moureau-Zabotto L, Servois V, Wardelmann E, Terrier P, Lazar AJ, Bovée JVMG, Le Péchoux C, Papai Z
Lancet Oncol 2019 Aug;20(8):1148-1159. Epub 2019 Jul 8 doi: 10.1016/S1470-2045(19)30326-2. PMID: 31296491
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Uno T, Itami J, Kato H
Anticancer Res 1995 Nov-Dec;15(6B):2655-7. PMID: 8669842

Recent systematic reviews

Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681

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