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Locally Advanced Small Intestinal Carcinoma

MedGen UID:
1649363
•Concept ID:
C4727194
•
Neoplastic Process

Definition

Small intestinal carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Small Intestinal Carcinoma

Professional guidelines

PubMed

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Small Bowel Adenocarcinoma: From Molecular Insights to Clinical Management.
Gelsomino F, Balsano R, De Lorenzo S, Garajová I
Curr Oncol 2022 Feb 17;29(2):1223-1236. doi: 10.3390/curroncol29020104. PMID: 35200603Free PMC Article

Recent clinical studies

Etiology

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial.
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Feasibility of Using Hydrogel Spacers for Borderline-Resectable and Locally Advanced Pancreatic Tumors.
Kerdsirichairat T, Narang AK, Thompson E, Kim SH, Rao A, Ding K, Shin EJ
Gastroenterology 2019 Oct;157(4):933-935. Epub 2019 Jul 12 doi: 10.1053/j.gastro.2019.07.012. PMID: 31306631Free PMC Article
Hypofractionated intensity-modulated radiotherapy in locally advanced unresectable pancreatic cancer: A pilot study.
De Felice F, Benevento I, Bulzonetti N, Shima B, Rubini F, Marampon F, Musio D, Tombolini V
Curr Probl Cancer 2019 Oct;43(5):495-503. Epub 2019 May 23 doi: 10.1016/j.currproblcancer.2019.04.003. PMID: 31146956
Ampullary tumors: endoscopic versus operative management.
Tran TC, Vitale GC
Surg Innov 2004 Dec;11(4):255-63. doi: 10.1177/155335060401100409. PMID: 15756395

Diagnosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Progress in the Treatment of Small Intestine Cancer.
Symons R, Daly D, Gandy R, Goldstein D, Aghmesheh M
Curr Treat Options Oncol 2023 Apr;24(4):241-261. Epub 2023 Feb 24 doi: 10.1007/s11864-023-01058-3. PMID: 36826686
Hypofractionated intensity-modulated radiotherapy in locally advanced unresectable pancreatic cancer: A pilot study.
De Felice F, Benevento I, Bulzonetti N, Shima B, Rubini F, Marampon F, Musio D, Tombolini V
Curr Probl Cancer 2019 Oct;43(5):495-503. Epub 2019 May 23 doi: 10.1016/j.currproblcancer.2019.04.003. PMID: 31146956
Radiation-induced distal ileal obstruction complicating ileostomy closure.
Zakaria Z, Toomey D, Deasy J
Tech Coloproctol 2014 Feb;18(2):195-8. Epub 2013 Mar 20 doi: 10.1007/s10151-013-0997-8. PMID: 23512579
Ampullary tumors: endoscopic versus operative management.
Tran TC, Vitale GC
Surg Innov 2004 Dec;11(4):255-63. doi: 10.1177/155335060401100409. PMID: 15756395

Therapy

FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
Duke ES, Bradford D, Marcovitz M, Amatya AK, Mishra-Kalyani PS, Nguyen E, Price LSL, Fourie Zirkelbach J, Li Y, Bi Y, Kraft J, Dorff SE, Scepura B, Stephenson M, Ojofeitimi I, Nair A, Han Y, Tezak Z, Lemery SJ, Pazdur R, Larkins E, Singh H
Clin Cancer Res 2023 Sep 15;29(18):3573-3578. doi: 10.1158/1078-0432.CCR-23-0459. PMID: 37265412Free PMC Article
Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial.
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Management of small bowel adenocarcinoma: making the most of the available evidence to inform routine practice.
Mazlom H, Teuwen LA, Peeters M
Curr Opin Oncol 2021 Jul 1;33(4):368-371. doi: 10.1097/CCO.0000000000000747. PMID: 33882527
Feasibility of Using Hydrogel Spacers for Borderline-Resectable and Locally Advanced Pancreatic Tumors.
Kerdsirichairat T, Narang AK, Thompson E, Kim SH, Rao A, Ding K, Shin EJ
Gastroenterology 2019 Oct;157(4):933-935. Epub 2019 Jul 12 doi: 10.1053/j.gastro.2019.07.012. PMID: 31306631Free PMC Article
Hypofractionated intensity-modulated radiotherapy in locally advanced unresectable pancreatic cancer: A pilot study.
De Felice F, Benevento I, Bulzonetti N, Shima B, Rubini F, Marampon F, Musio D, Tombolini V
Curr Probl Cancer 2019 Oct;43(5):495-503. Epub 2019 May 23 doi: 10.1016/j.currproblcancer.2019.04.003. PMID: 31146956

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Hypofractionated intensity-modulated radiotherapy in locally advanced unresectable pancreatic cancer: A pilot study.
De Felice F, Benevento I, Bulzonetti N, Shima B, Rubini F, Marampon F, Musio D, Tombolini V
Curr Probl Cancer 2019 Oct;43(5):495-503. Epub 2019 May 23 doi: 10.1016/j.currproblcancer.2019.04.003. PMID: 31146956
Gastrointestinal carcinoid tumors: diagnosis and treatment.
Stamatakos M, Kontzoglou K, Sargedi C, Tsaknaki S, Iannescu R, Safioleas C, Kaitanidi V, Safioleas M
Chirurgia (Bucur) 2010 Nov-Dec;105(6):759-66. PMID: 21351698
Pharyngo-cervical esophageal reconstruction.
Archibald S, Young JE, Thoma A
Clin Plast Surg 2005 Jul;32(3):339-46, vi. doi: 10.1016/j.cps.2005.01.002. PMID: 15979473
Ampullary tumors: endoscopic versus operative management.
Tran TC, Vitale GC
Surg Innov 2004 Dec;11(4):255-63. doi: 10.1177/155335060401100409. PMID: 15756395

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Radical Resection Combined With Intestinal Autotransplantation for Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy: A Report of 36 Consecutive Cases.
Liang T, Zhang Q, Wu G, Liu C, Bai X, Gao S, Ma T, Sun K, Yan S, Xiao W, Jiang T, Lu F, Zhang Y, Shen Y, Zhang M, Zhang X, Shan J
Ann Surg 2023 Nov 1;278(5):e1055-e1062. Epub 2023 Jan 24 doi: 10.1097/SLA.0000000000005797. PMID: 36727746
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Surgical approach in locally advanced colorectal cancer--combined, extended and compound surgery.
Sokolov M
Khirurgiia (Sofiia) 2013;(4):29-50. PMID: 24800318
Classification and treatment of anastomotic leakage after extended total gastrectomy in gastric carcinoma.
Csendes A, Díaz JC, Burdiles P, Braghetto I, Maluenda F, Nava O, Korn O
Hepatogastroenterology 1990 Dec;37 Suppl 2:174-7. PMID: 2083933

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Abdel-Rahman O, Elsayed Z, Elhalawani H
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD011746. doi: 10.1002/14651858.CD011746.pub2. PMID: 29624208Free PMC Article
Rectal carcinoids: a systematic review.
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484
Surgical management of the duodenal manifestations of familial adenomatous polyposis.
Parc Y, Mabrut JY, Shields C; Mallorca Group
Br J Surg 2011 Apr;98(4):480-4. Epub 2011 Jan 6 doi: 10.1002/bjs.7374. PMID: 21656714

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