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Thyroid Gland Follicular Tumor of Uncertain Malignant Potential

MedGen UID:
1650267
•Concept ID:
C4744484
•
Neoplastic Process
Synonym: Thyroid Gland Follicular Neoplasm of Uncertain Malignant Potential

Definition

An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with no nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Gamma-glutamyl cyclotransferase, a molecule identified from the invasive front of follicular thyroid carcinoma, is useful for differential diagnosis of follicular thyroid tumors.
Mitsuhashi T, Ogasawara S, Nakayama M, Kondo R, Akiba J, Murotani K, Ono T, Sato F, Umeno H, Yano H
Pathol Res Pract 2024 Dec;264:155678. Epub 2024 Oct 28 doi: 10.1016/j.prp.2024.155678. PMID: 39488118
Ultrasound and cytopathological characteristics of thyroid tumours of uncertain malignant potential - from diagnosis to treatment.
Żyłka A, Dobruch-Sobczak K, Piotrzkowska-Wróblewska H, Jędrzejczyk M, Góralski P, Gałczyński J, Bakuła-Zalewska E, Dedecjus M
Endokrynol Pol 2024;75(2):170-178. Epub 2024 Apr 22 doi: 10.5603/ep.98488. PMID: 38646986
Diagnostic criteria of well differentiated thyroid tumor of uncertain malignant potential; a histomorphological and immunohistochemical appraisal.
Yassin Fel-Z
J Egypt Natl Canc Inst 2015 Jun;27(2):59-67. Epub 2015 Mar 21 doi: 10.1016/j.jnci.2015.02.003. PMID: 25800580

Recent clinical studies

Etiology

Ultrasound and cytopathological characteristics of thyroid tumours of uncertain malignant potential - from diagnosis to treatment.
Żyłka A, Dobruch-Sobczak K, Piotrzkowska-Wróblewska H, Jędrzejczyk M, Góralski P, Gałczyński J, Bakuła-Zalewska E, Dedecjus M
Endokrynol Pol 2024;75(2):170-178. Epub 2024 Apr 22 doi: 10.5603/ep.98488. PMID: 38646986
Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article

Diagnosis

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

Therapy

Thyroid fine-needle aspiration with atypia of undetermined significance: a necessary or optional category?
Shi Y, Ding X, Klein M, Sugrue C, Matano S, Edelman M, Wasserman P
Cancer 2009 Oct 25;117(5):298-304. doi: 10.1002/cncy.20039. PMID: 19711470

Prognosis

Ultrasound and cytopathological characteristics of thyroid tumours of uncertain malignant potential - from diagnosis to treatment.
Żyłka A, Dobruch-Sobczak K, Piotrzkowska-Wróblewska H, Jędrzejczyk M, Góralski P, Gałczyński J, Bakuła-Zalewska E, Dedecjus M
Endokrynol Pol 2024;75(2):170-178. Epub 2024 Apr 22 doi: 10.5603/ep.98488. PMID: 38646986
Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

Clinical prediction guides

Surgical and Pathological Challenges in Thyroidectomy after Thermal Ablation of Thyroid Nodules.
Kuo TC, Chen KY, Hu HW, Jhuang JY, Lin MT, Chang CH, Wu MH
Thyroid 2024 Dec;34(12):1503-1512. Epub 2024 Nov 22 doi: 10.1089/thy.2024.0281. PMID: 39574349
Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347
Do benign thyroid nodules have malignant potential? An evidence-based review.
Arora N, Scognamiglio T, Zhu B, Fahey TJ 3rd
World J Surg 2008 Jul;32(7):1237-46. doi: 10.1007/s00268-008-9484-1. PMID: 18327528

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