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Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma

MedGen UID:
1651944
•Concept ID:
C4744990
•
Neoplastic Process

Definition

A small intestinal large cell neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Small Intestinal Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

NETest in advanced high-grade gastroenteropancreatic neuroendocrine neoplasms.
Sorbye H, Hjortland GO, Vestermark LW, Sundlov A, Assmus J, Couvelard A, Perren A, Langer SW
J Neuroendocrinol 2024 Nov;36(11):e13428. Epub 2024 Jun 27 doi: 10.1111/jne.13428. PMID: 38937137
Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article

Diagnosis

NETest in advanced high-grade gastroenteropancreatic neuroendocrine neoplasms.
Sorbye H, Hjortland GO, Vestermark LW, Sundlov A, Assmus J, Couvelard A, Perren A, Langer SW
J Neuroendocrinol 2024 Nov;36(11):e13428. Epub 2024 Jun 27 doi: 10.1111/jne.13428. PMID: 38937137
Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
Nassar H, Albores-Saavedra J, Klimstra DS
Am J Surg Pathol 2005 May;29(5):588-94. doi: 10.1097/01.pas.0000157974.05397.4f. PMID: 15832081

Therapy

Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Neuroendocrine carcinoma of the stomach with peripancreatic lymph node metastases successfully treated with pancreaticoduodenectomy.
Ma J, Kimura W, Takeshita A, Hirai I, Moriya T, Mizutani M
Hepatogastroenterology 2007 Oct-Nov;54(79):1945-50. PMID: 18251134
Endocrine cells in colorectal carcinomas. Immunohistochemical study.
Swatek J, Chibowski D
Pol J Pathol 2000;51(3):127-36. PMID: 11247395

Prognosis

Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Clinical prediction guides

NETest in advanced high-grade gastroenteropancreatic neuroendocrine neoplasms.
Sorbye H, Hjortland GO, Vestermark LW, Sundlov A, Assmus J, Couvelard A, Perren A, Langer SW
J Neuroendocrinol 2024 Nov;36(11):e13428. Epub 2024 Jun 27 doi: 10.1111/jne.13428. PMID: 38937137

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