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Recurrent Paget Disease of the Anal Canal

MedGen UID:
1652016
•Concept ID:
C4727365
•
Neoplastic Process
Synonym: Recurrent Paget's Disease of the Anal Canal

Definition

The reemergence of Paget disease of the anal canal after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Paget Disease of the Anal Canal

Professional guidelines

PubMed

Photodynamic therapy in the management of neoplasms of the perianal skin.
Petrelli NJ, Cebollero JA, Rodriguez-Bigas M, Mang T
Arch Surg 1992 Dec;127(12):1436-8. doi: 10.1001/archsurg.1992.01420120070013. PMID: 1365690
Treatment of intractable pruritus ani.
Eusebio EB, Graham J, Mody N
Dis Colon Rectum 1990 Sep;33(9):770-2. doi: 10.1007/BF02052324. PMID: 2390913

Recent clinical studies

Etiology

Hematoporphyrine injection-based photodynamic therapy for Perianal Paget's disease: A case report.
Zhao Y, Sun XF, Li CX, Zhou ZX, Wang DX, Zhao ZJ, Zhang GL, Chen YM, Wang XL
Photodiagnosis Photodyn Ther 2024 Dec;50:104352. Epub 2024 Oct 2 doi: 10.1016/j.pdpdt.2024.104352. PMID: 39366475
Extramammary Paget's disease of the perianal region.
Tulchinsky H, Zmora O, Brazowski E, Goldman G, Rabau M
Colorectal Dis 2004 May;6(3):206-9. doi: 10.1111/j.1463-1318.2004.00630.x. PMID: 15109389
The pagetoid variant of bladder urothelial carcinoma in situ A clinicopathological study of 11 cases.
Lopez-Beltran A, Luque RJ, Moreno A, Bollito E, Carmona E, Montironi R
Virchows Arch 2002 Aug;441(2):148-53. Epub 2002 Apr 4 doi: 10.1007/s00428-002-0627-8. PMID: 12189504
Anal carcinoma or "just hemorrhoids"?
Winburn GB
Am Surg 2001 Nov;67(11):1048-58. PMID: 11730221
Photodynamic therapy in the management of neoplasms of the perianal skin.
Petrelli NJ, Cebollero JA, Rodriguez-Bigas M, Mang T
Arch Surg 1992 Dec;127(12):1436-8. doi: 10.1001/archsurg.1992.01420120070013. PMID: 1365690

Diagnosis

Perianal Paget's disease complicated with lung adenocarcinoma and anal canal carcinoma: A case report and literature review.
Zhou L, Yang M, Wang T, Zhang J
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Aug 28;48(8):1274-1280. doi: 10.11817/j.issn.1672-7347.2023.220617. PMID: 37875369Free PMC Article
Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Anal intraepithelial neoplasia and other neoplastic precursor lesions of the anal canal and perianal region.
Shepherd NA
Gastroenterol Clin North Am 2007 Dec;36(4):969-87, ix. doi: 10.1016/j.gtc.2007.08.001. PMID: 17996800
Extramammary Paget's disease of the perianal region.
Tulchinsky H, Zmora O, Brazowski E, Goldman G, Rabau M
Colorectal Dis 2004 May;6(3):206-9. doi: 10.1111/j.1463-1318.2004.00630.x. PMID: 15109389
The pagetoid variant of bladder urothelial carcinoma in situ A clinicopathological study of 11 cases.
Lopez-Beltran A, Luque RJ, Moreno A, Bollito E, Carmona E, Montironi R
Virchows Arch 2002 Aug;441(2):148-53. Epub 2002 Apr 4 doi: 10.1007/s00428-002-0627-8. PMID: 12189504

Therapy

Hematoporphyrine injection-based photodynamic therapy for Perianal Paget's disease: A case report.
Zhao Y, Sun XF, Li CX, Zhou ZX, Wang DX, Zhao ZJ, Zhang GL, Chen YM, Wang XL
Photodiagnosis Photodyn Ther 2024 Dec;50:104352. Epub 2024 Oct 2 doi: 10.1016/j.pdpdt.2024.104352. PMID: 39366475
Perianal extramammary Paget disease treated with topical imiquimod and oral cimetidine.
Gray J, Gray A, Swan J, Eberhardt J, Mudaliar K, Tung R
Cutis 2018 Apr;101(4):E19-E22. PMID: 29763492
Extramammary Paget's disease of the perianal region.
Tulchinsky H, Zmora O, Brazowski E, Goldman G, Rabau M
Colorectal Dis 2004 May;6(3):206-9. doi: 10.1111/j.1463-1318.2004.00630.x. PMID: 15109389
The pagetoid variant of bladder urothelial carcinoma in situ A clinicopathological study of 11 cases.
Lopez-Beltran A, Luque RJ, Moreno A, Bollito E, Carmona E, Montironi R
Virchows Arch 2002 Aug;441(2):148-53. Epub 2002 Apr 4 doi: 10.1007/s00428-002-0627-8. PMID: 12189504
Photodynamic therapy in the management of neoplasms of the perianal skin.
Petrelli NJ, Cebollero JA, Rodriguez-Bigas M, Mang T
Arch Surg 1992 Dec;127(12):1436-8. doi: 10.1001/archsurg.1992.01420120070013. PMID: 1365690

Prognosis

Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
Perianal extramammary Paget disease treated with topical imiquimod and oral cimetidine.
Gray J, Gray A, Swan J, Eberhardt J, Mudaliar K, Tung R
Cutis 2018 Apr;101(4):E19-E22. PMID: 29763492
Extramammary Paget's disease: extended subclinical growth detected using three-dimensional histology in routine paraffin procedure and course of the disease.
Boehringer A, Leiter U, Metzler G, Moehrle M, Garbe C, Breuninger H
Dermatol Surg 2011 Oct;37(10):1417-26. Epub 2011 Jul 18 doi: 10.1111/j.1524-4725.2011.02091.x. PMID: 21767327
Extramammary Paget's disease of the perianal region.
Tulchinsky H, Zmora O, Brazowski E, Goldman G, Rabau M
Colorectal Dis 2004 May;6(3):206-9. doi: 10.1111/j.1463-1318.2004.00630.x. PMID: 15109389
Photodynamic therapy in the management of neoplasms of the perianal skin.
Petrelli NJ, Cebollero JA, Rodriguez-Bigas M, Mang T
Arch Surg 1992 Dec;127(12):1436-8. doi: 10.1001/archsurg.1992.01420120070013. PMID: 1365690

Clinical prediction guides

Perianal Paget's disease complicated with lung adenocarcinoma and anal canal carcinoma: A case report and literature review.
Zhou L, Yang M, Wang T, Zhang J
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Aug 28;48(8):1274-1280. doi: 10.11817/j.issn.1672-7347.2023.220617. PMID: 37875369Free PMC Article
Perianal Paget's-an aggressive disease.
Rudnicki Y, Stapleton SM, Batra R, Gan T, Mathis KL, Kelley SR
Colorectal Dis 2023 Jun;25(6):1213-1221. Epub 2023 Mar 21 doi: 10.1111/codi.16549. PMID: 36945125
A therapeutic approach to perianal extramammary Paget's disease: topical imiquimod can be useful to prevent or defer surgery.
Vereecken P, Awada A, Ghanem G, Marques da Costa C, Larsimont D, Simoens C, Mendes da Costa P, Hendlisz A
Med Sci Monit 2007 Jun;13(6):CS75-7. PMID: 17534239
Treatment of intractable pruritus ani.
Eusebio EB, Graham J, Mody N
Dis Colon Rectum 1990 Sep;33(9):770-2. doi: 10.1007/BF02052324. PMID: 2390913

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