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Thyroid Gland Follicular Carcinoma, Encapsulated Angioinvasive

MedGen UID:
1652915
•Concept ID:
C4744586
•
Neoplastic Process
Synonym: FTC, Encapsulated Angioinvasive

Definition

An encapsulated follicular carcinoma of the thyroid gland which shows angioinvasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Carcinoma, Encapsulated Angioinvasive

Professional guidelines

PubMed

Evaluation of the follicular patterned thyroid lesions based on the WHO 2022 criteria with an emphasis on the grey-zone lesions.
Misra S, Dhawan S, Badwal S, Sengupta A, Khosla A, Agarwal SK, Rao S
Ann Diagn Pathol 2024 Aug;71:152282. Epub 2024 Feb 14 doi: 10.1016/j.anndiagpath.2024.152282. PMID: 38522359
Selection Criteria for Completion Thyroidectomy in Follicular Thyroid Carcinoma Using Primary Tumor Size and TERT Promoter Mutational Status.
Park H, Heo J, Ki CS, Shin JH, Oh YL, Son YI, Kim JS, Kim SW, Chung JH, Kim TY, Kim TH, Kim JH
Ann Surg Oncol 2023 May;30(5):2916-2925. Epub 2023 Jan 13 doi: 10.1245/s10434-022-13089-5. PMID: 36637642Free PMC Article

Recent clinical studies

Etiology

RAS-Mutant Follicular Thyroid Tumors: A Continuous Challenge for Pathologists.
Hernandez-Prera JC, Wenig BM
Endocr Pathol 2024 Sep;35(3):167-184. Epub 2024 Jun 18 doi: 10.1007/s12022-024-09812-5. PMID: 38888731
Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma.
Yamazaki H, Sugino K, Katoh R, Matsuzu K, Kitagawa W, Nagahama M, Rino Y, Saito A, Ito K
J Clin Endocrinol Metab 2024 Apr 19;109(5):1291-1300. doi: 10.1210/clinem/dgad689. PMID: 38006314
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Encapsulated malignant follicular cell-derived thyroid tumors.
Ghossein R
Endocr Pathol 2010 Dec;21(4):212-8. doi: 10.1007/s12022-010-9141-8. PMID: 21088998

Diagnosis

Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings.
Ito Y, Miyauchi A
Eur Thyroid J 2024 Oct 1;13(5) Epub 2024 Oct 4 doi: 10.1530/ETJ-24-0196. PMID: 39213599Free PMC Article
RAS-Mutant Follicular Thyroid Tumors: A Continuous Challenge for Pathologists.
Hernandez-Prera JC, Wenig BM
Endocr Pathol 2024 Sep;35(3):167-184. Epub 2024 Jun 18 doi: 10.1007/s12022-024-09812-5. PMID: 38888731
Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma.
Yamazaki H, Sugino K, Katoh R, Matsuzu K, Kitagawa W, Nagahama M, Rino Y, Saito A, Ito K
J Clin Endocrinol Metab 2024 Apr 19;109(5):1291-1300. doi: 10.1210/clinem/dgad689. PMID: 38006314
Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
The surgical dilemma of primary surgery for follicular thyroid neoplasms.
Staubitz JI, Musholt PB, Musholt TJ
Best Pract Res Clin Endocrinol Metab 2019 Aug;33(4):101292. Epub 2019 Jul 9 doi: 10.1016/j.beem.2019.101292. PMID: 31434622

Therapy

Clinical Outcomes and Implications of Radioactive Iodine Therapy on Cancer-specific Survival in WHO Classification of FTC.
Li G, Ye Z, Wei T, Zhu J, Li Z, Lei J
J Clin Endocrinol Metab 2024 Aug 13;109(9):2294-2305. doi: 10.1210/clinem/dgae122. PMID: 38436929
Follicular neoplasms of the thyroid. Total circumferential evaluation of the fibrous capsule.
Yamashina M
Am J Surg Pathol 1992 Apr;16(4):392-400. doi: 10.1097/00000478-199204000-00008. PMID: 1373582

Prognosis

Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma.
Yamazaki H, Sugino K, Katoh R, Matsuzu K, Kitagawa W, Nagahama M, Rino Y, Saito A, Ito K
J Clin Endocrinol Metab 2024 Apr 19;109(5):1291-1300. doi: 10.1210/clinem/dgad689. PMID: 38006314
Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology.
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T
J Clin Endocrinol Metab 2018 Jul 1;103(7):2640-2650. doi: 10.1210/jc.2018-00277. PMID: 29726952

Clinical prediction guides

Clinical Outcomes and Implications of Radioactive Iodine Therapy on Cancer-specific Survival in WHO Classification of FTC.
Li G, Ye Z, Wei T, Zhu J, Li Z, Lei J
J Clin Endocrinol Metab 2024 Aug 13;109(9):2294-2305. doi: 10.1210/clinem/dgae122. PMID: 38436929
Role of the Degree of Vascular Invasion in Predicting Prognosis of Follicular Thyroid Carcinoma.
Yamazaki H, Sugino K, Katoh R, Matsuzu K, Kitagawa W, Nagahama M, Rino Y, Saito A, Ito K
J Clin Endocrinol Metab 2024 Apr 19;109(5):1291-1300. doi: 10.1210/clinem/dgad689. PMID: 38006314
Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology.
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T
J Clin Endocrinol Metab 2018 Jul 1;103(7):2640-2650. doi: 10.1210/jc.2018-00277. PMID: 29726952

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