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Testicular Follicular Lymphoma

MedGen UID:
1654691
•Concept ID:
C4725856
•
Neoplastic Process

Definition

A distinctive variant of follicular lymphoma arising from the testis. It has been reported with higher frequency in children, but is also seen rarely in adults. It differs biologically from nodal follicular lymphoma because it lacks evidence of the BCL2 translocation. It is usually of high cytological grade, usually grade 3A, but has a good prognosis, even without additional therapy beyond surgical excision. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Follicular Lymphoma

Professional guidelines

PubMed

Testicular diffuse large cell lymphoma with tubule preservation--molecular genetic evidence of transformation from previous follicular lymphoma.
Lasota J, Nordling S, Miettinen M
Virchows Arch 2000 Mar;436(3):276-83. doi: 10.1007/s004280050041. PMID: 10782887

Recent clinical studies

Etiology

Evolution of Lymphoma Diagnosis in the Era of Personalized Medicine: A Marriage of Pathology and Genomics for Clinical Practice.
Jaffe ES
Am J Pathol 2023 Dec;193(12):1880-1886. Epub 2023 Sep 19 doi: 10.1016/j.ajpath.2023.08.012. PMID: 37734589Free PMC Article
Detection of a second primary cancer in a 18F-fluorocholine PET/CT - multicentre retrospective analysis on a group of 1345 prostate cancer patients.
Cegla P, Scibisz-Dziedzic K, Witkowska K, Kubiak A, Wierzchoslawska E, Kycler W, Chrapko B, Czepczyński R
Nucl Med Rev Cent East Eur 2022;25(1):25-30. doi: 10.5603/NMR.a2022.0006. PMID: 35137934
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449

Diagnosis

Evolution of Lymphoma Diagnosis in the Era of Personalized Medicine: A Marriage of Pathology and Genomics for Clinical Practice.
Jaffe ES
Am J Pathol 2023 Dec;193(12):1880-1886. Epub 2023 Sep 19 doi: 10.1016/j.ajpath.2023.08.012. PMID: 37734589Free PMC Article
Follicular lymphoma and marginal zone lymphoma: how many diseases?
Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631Free PMC Article
Pathology of extra-nodal non Hodgkin lymphomas.
Wright DH
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):319-28. Epub 2012 Apr 3 doi: 10.1016/j.clon.2012.02.004. PMID: 22480571
Multiple osteolytic lesions and testicular involvement at first relapse of follicular lymphoma grade 1 in transformation.
Dölken MT, Schüler F, Hirt C, Lorenz G, Hosten N, Dölken G
Leuk Lymphoma 2006 Feb;47(2):369-71. doi: 10.1080/10428190500287687. PMID: 16321874
Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia.
Swerdlow SH
Am J Clin Pathol 2004 Dec;122 Suppl:S98-109. doi: 10.1309/4BKNAKE4D7CT3C1B. PMID: 15690646

Therapy

Diffuse large B-cell lymphoma of stomach presenting with paraneoplastic cerebellar degeneration syndrome.
Nomani AZ, Wazir M, Kashmir SB, Qureshi MS
J Coll Physicians Surg Pak 2014 Mar;24 Suppl 1:S11-3. PMID: 24717988
Pathology of extra-nodal non Hodgkin lymphomas.
Wright DH
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):319-28. Epub 2012 Apr 3 doi: 10.1016/j.clon.2012.02.004. PMID: 22480571
Multiple osteolytic lesions and testicular involvement at first relapse of follicular lymphoma grade 1 in transformation.
Dölken MT, Schüler F, Hirt C, Lorenz G, Hosten N, Dölken G
Leuk Lymphoma 2006 Feb;47(2):369-71. doi: 10.1080/10428190500287687. PMID: 16321874
Follicular lymphoma with bilateral testicular and epididymal involvement: case report and review of the literature.
Jacobsen E, Lomo L, Briccetti F, Longtine J, Freedman A
Leuk Lymphoma 2005 Nov;46(11):1663-6. doi: 10.1080/10428190500178548. PMID: 16236619
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449

Prognosis

Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.
Mansoor A, Akhter A, Hamidi M, Roshan TM, Shabani-Rad MT, Stewart D
Anticancer Res 2023 Nov;43(11):4801-4807. doi: 10.21873/anticanres.16677. PMID: 37909960
Primary follicular lymphoma of the testis in children and adolescents.
Lones MA, Raphael M, McCarthy K, Wotherspoon A, Terrier-Lacombe MJ, Ramsay AD, Maclennan K, Cairo MS, Gerrard M, Michon J, Patte C, Pinkerton R, Sender L, Auperin A, Sposto R, Weston C, Heerema NA, Sanger WG, von Allmen D, Perkins SL
J Pediatr Hematol Oncol 2012 Jan;34(1):68-71. doi: 10.1097/MPH.0b013e31820e4636. PMID: 22215099Free PMC Article
Primary follicular lymphoma of the testis and epididymis in adults.
Bacon CM, Ye H, Diss TC, McNamara C, Kueck B, Hasserjian RP, Rohatiner AZ, Ferry J, Du MQ, Dogan A
Am J Surg Pathol 2007 Jul;31(7):1050-8. doi: 10.1097/PAS.0b013e31802ee4ab. PMID: 17592272
Primary follicular lymphoma of the testis in childhood: an entity with peculiar clinical and molecular characteristics.
Pileri SA, Sabattini E, Rosito P, Zinzani PL, Ascani S, Fraternali-Orcioni G, Gamberi B, Piccioli M, Vivenza D, Falini B, Gaidano G
J Clin Pathol 2002 Sep;55(9):684-8. doi: 10.1136/jcp.55.9.684. PMID: 12194999Free PMC Article
Malignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis.
Ferry JA, Harris NL, Young RH, Coen J, Zietman A, Scully RE
Am J Surg Pathol 1994 Apr;18(4):376-90. doi: 10.1097/00000478-199404000-00006. PMID: 8141430

Clinical prediction guides

Exploring TBL1XR1 and NCOR1 Expression in B-cell Lymphoma Subtypes: Interaction With DNA Damage Repair Genes.
Mansoor A, Akhter A, Hamidi M, Roshan TM, Shabani-Rad MT, Stewart D
Anticancer Res 2023 Nov;43(11):4801-4807. doi: 10.21873/anticanres.16677. PMID: 37909960
Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.
Oda R, Okuda K, Murase T, Watanabe T, Sakane T, Tatematsu T, Yokota K, Haneda H, Nakanishi R
Thorac Cancer 2019 Jan;10(1):116-119. Epub 2018 Nov 23 doi: 10.1111/1759-7714.12914. PMID: 30467988Free PMC Article
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449
Molecular pathological analysis of testicular diffuse large cell lymphomas.
Hyland J, Lasota J, Jasinski M, Petersen RO, Nordling S, Miettinen M
Hum Pathol 1998 Nov;29(11):1231-9. doi: 10.1016/s0046-8177(98)90250-7. PMID: 9824100

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