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Malignant Pancreatic Insulinoma

MedGen UID:
1655258
Concept ID:
C4721412
Neoplastic Process
Synonyms: Beta cell tumor, malignant; Insulinoma, malignant; Malignant beta cell tumor; Malignant Insulinoma; Malignant insulinoma; Pancreatic Beta Islet Cell Carcinoma; Pancreatic Insulin Producing Carcinoma
SNOMED CT: Malignant beta cell tumor (20955008); Malignant insulinoma (20955008); Malignant insulinoma (713189001); Insulinoma, malignant (20955008); Beta cell tumor, malignant (20955008)

Definition

An insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin. It displays vascular invasion and metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Pancreatic Insulinoma

Professional guidelines

PubMed

Giannis D, Moris D, Karachaliou GS, Tsilimigras DI, Karaolanis G, Papalampros A, Felekouras E
J BUON 2020 May-Jun;25(3):1302-1314. PMID: 32862570
Scoazec JY, Couvelard A, Leteurtre E, Terris B; French Endocrine Society
Ann Endocrinol (Paris) 2013 Jul;74(3):203-6. Epub 2013 Jun 14 doi: 10.1016/j.ando.2013.05.005. PMID: 23768679
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article

Recent clinical studies

Etiology

Christ E, Iacovazzo D, Korbonits M, Perren A
Endocr Relat Cancer 2023 Jun 1;30(6) Epub 2023 May 16 doi: 10.1530/ERC-22-0327. PMID: 36952647
Douillard C, Jannin A, Vantyghem MC
Ann Endocrinol (Paris) 2020 Jun;81(2-3):110-117. Epub 2020 Apr 10 doi: 10.1016/j.ando.2020.04.003. PMID: 32409005
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Grant CS
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):783-98. doi: 10.1016/j.bpg.2005.05.008. PMID: 16253900
Tseng LJ, Jao YT, Liu SM, Yang TM, Tsai CC, Mo LR
Gastrointest Endosc 2003 Jul;58(1):97-8. doi: 10.1067/mge.2003.287. PMID: 12838231

Diagnosis

Palani G, Stortz E, Moheet A
Endocr Pract 2023 Apr;29(4):286-294. Epub 2022 Dec 2 doi: 10.1016/j.eprac.2022.11.010. PMID: 36464132
Giannis D, Moris D, Karachaliou GS, Tsilimigras DI, Karaolanis G, Papalampros A, Felekouras E
J BUON 2020 May-Jun;25(3):1302-1314. PMID: 32862570
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Vanderveen K, Grant C
Cancer Treat Res 2010;153:235-52. doi: 10.1007/978-1-4419-0857-5_13. PMID: 19957228
Besemer B, Müssig K
Exp Clin Endocrinol Diabetes 2010 Jan;118(1):9-18. Epub 2009 Apr 16 doi: 10.1055/s-0029-1202272. PMID: 19373751

Therapy

Hofland J, Refardt JC, Feelders RA, Christ E, de Herder WW
J Clin Endocrinol Metab 2024 Mar 15;109(4):1109-1118. doi: 10.1210/clinem/dgad641. PMID: 37925662Free PMC Article
Erhamamcı S, Sager S, Asa S, Uslu L, Akgun E, Sonmezoglu K
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2020 Nov-Dec;39(6):383-386. Epub 2020 May 30 doi: 10.1016/j.remn.2019.12.002. PMID: 32487444
Krampitz GW, Norton JA
Curr Probl Surg 2013 Nov;50(11):509-45. doi: 10.1067/j.cpsurg.2013.08.001. PMID: 24206780
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Chun J, Doherty GM
Curr Opin Oncol 2001 Jan;13(1):52-6. doi: 10.1097/00001622-200101000-00010. PMID: 11148686

Prognosis

Anderson CW, Bennett JJ
Surg Oncol Clin N Am 2016 Apr;25(2):363-74. Epub 2016 Feb 18 doi: 10.1016/j.soc.2015.12.003. PMID: 27013370
Krampitz GW, Norton JA
Curr Probl Surg 2013 Nov;50(11):509-45. doi: 10.1067/j.cpsurg.2013.08.001. PMID: 24206780
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Grant CS
Best Pract Res Clin Gastroenterol 2005 Oct;19(5):783-98. doi: 10.1016/j.bpg.2005.05.008. PMID: 16253900
Grant CS
Surg Oncol Clin N Am 1998 Oct;7(4):819-44. PMID: 9735136

Clinical prediction guides

Crinò SF, Napoleon B, Facciorusso A, Lakhtakia S, Borbath I, Caillol F, Do-Cong Pham K, Rizzatti G, Forti E, Palazzo L, Belle A, Vilmann P, van Laethem JL, Mohamadnejad M, Godat S, Hindryckx P, Benson A, Tacelli M, De Nucci G, Binda C, Kovacevic B, Jacob H, Partelli S, Falconi M, Salvia R, Landoni L; ERASING study collaborators, Larghi A
Clin Gastroenterol Hepatol 2023 Oct;21(11):2834-2843.e2. Epub 2023 Mar 4 doi: 10.1016/j.cgh.2023.02.022. PMID: 36871765
Deguelte S, de Mestier L, Hentic O, Cros J, Lebtahi R, Hammel P, Kianmanesh R
J Visc Surg 2018 Dec;155(6):483-492. Epub 2018 Nov 15 doi: 10.1016/j.jviscsurg.2018.08.010. PMID: 30448206
Birol M, Kumar S, Rhoades E, Miranker AD
Nat Commun 2018 Apr 3;9(1):1312. doi: 10.1038/s41467-018-03651-9. PMID: 29615609Free PMC Article
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, Kobayashi M, Hanazaki K
World J Gastroenterol 2013 Feb 14;19(6):829-37. doi: 10.3748/wjg.v19.i6.829. PMID: 23430217Free PMC Article
Virally ML, Guillausseau PJ
Diabetes Metab 1999 Dec;25(6):477-90. PMID: 10633872

Recent systematic reviews

Guerrero-Pérez F, Vilarrasa N, Huánuco LV, Busquets J, Secanella L, Vercher-Conejero JL, Vidal N, Näf Cortés S, Villabona C
Rev Endocr Metab Disord 2023 Dec;24(6):1135-1146. Epub 2023 Jul 12 doi: 10.1007/s11154-023-09824-2. PMID: 37434098
Shah R, Garg R, Majmundar M, Purandare N, Malhotra G, Patil V, Ramteke-Jadhav S, Lila A, Shah N, Bandgar T
Clin Endocrinol (Oxf) 2021 Aug;95(2):354-364. Epub 2021 Jan 21 doi: 10.1111/cen.14406. PMID: 33386617
Maiorano BA, Schinzari G, Chiloiro S, Visconti F, Milardi D, Bianchi A
Protein Pept Lett 2020;27(12):1276-1287. doi: 10.2174/0929866527666200504122116. PMID: 31804164
Wang H, Ba Y, Xing Q, Du JL
PLoS One 2018;13(10):e0206099. Epub 2018 Oct 23 doi: 10.1371/journal.pone.0206099. PMID: 30352083Free PMC Article
Hurtado-Pardo L, Cienfuegos JA, Ruiz-Canela M, Panadero P, Benito A, Hernández Lizoain JL
Rev Esp Enferm Dig 2017 Nov;109(11):778-787. doi: 10.17235/reed.2017.5044/2017. PMID: 29072081

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