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Carcinoma, Pancreatic Ductal

MedGen UID:
165776
Concept ID:
C0887833
Neoplastic Process
Synonyms: Carcinoma, Ductal, Pancreatic; Carcinoma, Pancreas Duct-Cell; Carcinomas, Pancreas Duct-Cell; Carcinomas, Pancreatic Ductal; Duct Cell Carcinoma of the Pancreas; Duct Cell Carcinoma, Pancreas; Duct-Cell Carcinoma of the Pancreas; Duct-Cell Carcinoma, Pancreas; Duct-Cell Carcinomas, Pancreas; Ductal Carcinoma of the Pancreas; Ductal Carcinoma, Pancreatic; Ductal Carcinomas, Pancreatic; Pancreas Duct-Cell Carcinoma; Pancreas Duct-Cell Carcinomas; Pancreatic Duct Cell Carcinoma; Pancreatic Ductal Carcinoma; Pancreatic Ductal Carcinomas

Definition

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma, Pancreatic Ductal

Professional guidelines

PubMed

Macarulla T, Fernández T, Gallardo ME, Hernando O, López AM, Hidalgo M
Clin Transl Oncol 2017 Oct;19(10):1199-1204. Epub 2017 Jun 21 doi: 10.1007/s12094-017-1683-5. PMID: 28639051
Frampas E, David A, Regenet N, Touchefeu Y, Meyer J, Morla O
Diagn Interv Imaging 2016 Dec;97(12):1207-1223. Epub 2016 Aug 24 doi: 10.1016/j.diii.2016.07.008. PMID: 27567314
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Recent clinical studies

Etiology

Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Younan G
Surg Clin North Am 2020 Jun;100(3):565-580. Epub 2020 Apr 9 doi: 10.1016/j.suc.2020.02.008. PMID: 32402301
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Vege SS, Ziring B, Jain R, Moayyedi P; Clinical Guidelines Committee; American Gastroenterology Association
Gastroenterology 2015 Apr;148(4):819-22; quize12-3. doi: 10.1053/j.gastro.2015.01.015. PMID: 25805375
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Therapy

Hu ZI, O'Reilly EM
Nat Rev Gastroenterol Hepatol 2024 Jan;21(1):7-24. Epub 2023 Oct 5 doi: 10.1038/s41575-023-00840-w. PMID: 37798442
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
Piersma B, Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2020 Apr;1873(2):188356. Epub 2020 Mar 5 doi: 10.1016/j.bbcan.2020.188356. PMID: 32147542Free PMC Article
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C, Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J, Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M, Reddy A, Röelli C, Ruddy DA, Salangsang F, Santacroce F, Singh AP, Tang Y, Tinetto W, Tobler S, Velazquez R, Venkatesan K, Von Arx F, Wang HQ, Wang Z, Wiesmann M, Wyss D, Xu F, Bitter H, Atadja P, Lees E, Hofmann F, Li E, Keen N, Cozens R, Jensen MR, Pryer NK, Williams JA, Sellers WR
Nat Med 2015 Nov;21(11):1318-25. Epub 2015 Oct 19 doi: 10.1038/nm.3954. PMID: 26479923

Prognosis

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
O'Kane GM, Ladak F, Gallinger S
CMAJ 2021 Jun 7;193(23):E844-E851. doi: 10.1503/cmaj.201450. PMID: 34099468Free PMC Article
Ayres Pereira M, Chio IIC
Genes (Basel) 2019 Dec 19;11(1) doi: 10.3390/genes11010006. PMID: 31861620Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Siriwardena AK, Siriwardena AM
BMJ 2014 Oct 31;349:g6385. doi: 10.1136/bmj.g6385. PMID: 25361852

Clinical prediction guides

Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Ethun CG, Kooby DA
J Surg Oncol 2016 Mar;113(3):283-8. Epub 2015 Nov 25 doi: 10.1002/jso.24092. PMID: 26603829
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Lee ES, Lee JM
World J Gastroenterol 2014 Jun 28;20(24):7864-77. doi: 10.3748/wjg.v20.i24.7864. PMID: 24976723Free PMC Article

Recent systematic reviews

Hong J, Fu Y, Chen X, Zhang Y, Li X, Li T, Liu Y, Fan M, Lin R
Int J Surg 2024 Sep 1;110(9):5781-5794. doi: 10.1097/JS9.0000000000001724. PMID: 38847785Free PMC Article
Chandana SR, Woods LM, Maxwell F, Gandolfo R, Bekaii-Saab T
Eur J Cancer 2024 Feb;198:113471. Epub 2023 Dec 12 doi: 10.1016/j.ejca.2023.113471. PMID: 38154392
Wood LD, Adsay NV, Basturk O, Brosens LAA, Fukushima N, Hong SM, Kim SJ, Lee JW, Luchini C, Noë M, Pitman MB, Scarpa A, Singhi AD, Tanaka M, Furukawa T
Pancreatology 2023 Nov;23(7):878-891. Epub 2023 Aug 11 doi: 10.1016/j.pan.2023.08.002. PMID: 37604731
Li HB, Yang ZH, Guo QQ
Cell Commun Signal 2021 Nov 24;19(1):117. doi: 10.1186/s12964-021-00789-w. PMID: 34819086Free PMC Article
Carotenuto P, Amato F, Lampis A, Rae C, Hedayat S, Previdi MC, Zito D, Raj M, Guzzardo V, Sclafani F, Lanese A, Parisi C, Vicentini C, Said-Huntingford I, Hahne JC, Hallsworth A, Kirkin V, Young K, Begum R, Wotherspoon A, Kouvelakis K, Azevedo SX, Michalarea V, Upstill-Goddard R, Rao S, Watkins D, Starling N, Sadanandam A, Chang DK, Biankin AV, Jamieson NB, Scarpa A, Cunningham D, Chau I, Workman P, Fassan M, Valeri N, Braconi C
Nat Commun 2021 Nov 18;12(1):6738. doi: 10.1038/s41467-021-27099-6. PMID: 34795259Free PMC Article

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