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Metastatic Lung Adenocarcinoma

MedGen UID:
1660921
•Concept ID:
C4744444
•
Neoplastic Process

Definition

Lung adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lung Adenocarcinoma

Professional guidelines

PubMed

First-line treatment of driver gene-negative metastatic lung adenocarcinoma with malignant pleural effusion: Should chemotherapy be combined with an immune checkpoint inhibitor or bevacizumab?
Zhao Y, Mei T, Na F, Tian X, Ao R, Long X, Luo Q, Duan P, Zhu J, Wang Y, Huang M, Liu Y, Gong Y
Invest New Drugs 2024 Apr;42(2):196-206. Epub 2024 Feb 22 doi: 10.1007/s10637-024-01424-4. PMID: 38386170Free PMC Article
Utility of GATA3 in the differential diagnosis of pheochromocytoma.
Perrino CM, Ho A, Dall CP, Zynger DL
Histopathology 2017 Sep;71(3):475-479. Epub 2017 Jun 5 doi: 10.1111/his.13229. PMID: 28374498
Ceritinib for the treatment of late-stage (metastatic) non-small cell lung cancer.
Massarelli E, Papadimitrakopoulou V
Clin Cancer Res 2015 Feb 15;21(4):670-4. Epub 2015 Jan 6 doi: 10.1158/1078-0432.CCR-14-1291. PMID: 25564153

Recent clinical studies

Etiology

Marantic Endocarditis in Metastatic Lung Adenocarcinoma.
Palicherla A, Pusapati S, Anugula D, Thandra A
Methodist Debakey Cardiovasc J 2023;19(4):100-103. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1243. PMID: 37547896Free PMC Article
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Pembrolizumab-induced acute right L5 neuritis unresponsive to steroids.
Fitzpatrick L, Lwin Z, Gericke C
BMJ Case Rep 2022 Nov 22;15(11) doi: 10.1136/bcr-2022-250971. PMID: 36414343Free PMC Article
Retrospective Data Analysis of Patients With Metastatic Lung Adenocarcinoma With or Without KRAS-Mutation or TTF1-Expression.
Moeller M, Schaedlich F, Schuette W
Cancer Control 2022 Jan-Dec;29:10732748221126949. doi: 10.1177/10732748221126949. PMID: 36355617Free PMC Article
Prognostic factors of EGFR-mutated metastatic adenocarcinoma of lung.
Ng KS, King Sun C, Boom Ting K, Ting Kun AY
Eur J Radiol 2020 Feb;123:108780. Epub 2019 Dec 10 doi: 10.1016/j.ejrad.2019.108780. PMID: 31846863

Diagnosis

Metastatic Lung Adenocarcinoma Presenting as Hydrocele.
Gupta S, Erickson LA
Mayo Clin Proc 2023 Dec;98(12):1894-1896. doi: 10.1016/j.mayocp.2023.08.009. PMID: 38044007
Marantic Endocarditis in Metastatic Lung Adenocarcinoma.
Palicherla A, Pusapati S, Anugula D, Thandra A
Methodist Debakey Cardiovasc J 2023;19(4):100-103. Epub 2023 Aug 1 doi: 10.14797/mdcvj.1243. PMID: 37547896Free PMC Article
A user's guide to lorlatinib.
Nagasaka M, Ge Y, Sukari A, Kukreja G, Ou SI
Crit Rev Oncol Hematol 2020 Jul;151:102969. Epub 2020 May 11 doi: 10.1016/j.critrevonc.2020.102969. PMID: 32416346
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.
Kim N, Kim HK, Lee K, Hong Y, Cho JH, Choi JW, Lee JI, Suh YL, Ku BM, Eum HH, Choi S, Choi YL, Joung JG, Park WY, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ, Lee HO
Nat Commun 2020 May 8;11(1):2285. doi: 10.1038/s41467-020-16164-1. PMID: 32385277Free PMC Article
Metastatic Lung Adenocarcinoma.
Kolomeyer AM, Brucker AJ, O'Brien JM
Ophthalmology 2017 Jul;124(7):969. doi: 10.1016/j.ophtha.2016.12.036. PMID: 28645343

Therapy

Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
The efficacy of T790M mutation testing in liquid biopsy-Real clinic data.
Krawczyk P, Grzycka-Kowalczyk L, Błach J, Reszka K, Chmielewska I, Kieszko R, Wójcik-Superczyńska M, Szczyrek M, Jankowski T, Milanowski J
PLoS One 2022;17(5):e0267846. Epub 2022 May 6 doi: 10.1371/journal.pone.0267846. PMID: 35522668Free PMC Article
Lemierre's syndrome masking metastatic lung adenocarcinoma.
Naran R, Dattani V, Madani Y
Thorax 2022 Mar;77(3):314-316. Epub 2022 Jan 7 doi: 10.1136/thoraxjnl-2021-217330. PMID: 34996853
Metastatic Lung Adenocarcinoma.
Kolomeyer AM, Brucker AJ, O'Brien JM
Ophthalmology 2017 Jul;124(7):969. doi: 10.1016/j.ophtha.2016.12.036. PMID: 28645343
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.
Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, Su WC, Bennouna J, Kato T, Gorbunova V, Lee KH, Shah R, Massey D, Zazulina V, Shahidi M, Schuler M
J Clin Oncol 2013 Sep 20;31(27):3327-34. Epub 2013 Jul 1 doi: 10.1200/JCO.2012.44.2806. PMID: 23816960

Prognosis

Complete response to capmatinib in a patient with metastatic lung adenocarcinoma harboring CD47-MET fusion: a case report.
Alves de Souza G, Dornellas DMS, Campregher PV, Teixeira CHA, Schvartsman G
Oncologist 2024 Sep 6;29(9):764-767. doi: 10.1093/oncolo/oyae106. PMID: 38832711Free PMC Article
m(6) A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis.
Yang X, Bai Q, Chen W, Liang J, Wang F, Gu W, Liu L, Li Q, Chen Z, Zhou A, Long J, Tian H, Wu J, Ding X, Zhou N, Li M, Yang Y, Cai J
Adv Sci (Weinh) 2023 Jul;10(20):e2206744. Epub 2023 May 12 doi: 10.1002/advs.202206744. PMID: 37171793Free PMC Article
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Recurrent Pericardial Effusion While Receiving Nivolumab for Metastatic Lung Adenocarcinoma: Case Report and Review of the Literature.
Vittorio A, Sharma R, Siejka D, Bhattarai K, Hardikar A
Clin Lung Cancer 2018 Sep;19(5):e717-e720. Epub 2018 May 26 doi: 10.1016/j.cllc.2018.05.010. PMID: 29937384
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article

Clinical prediction guides

Metastatic Lung Adenocarcinoma Received Combined 177 Lu-FAP-2286 Radiation Therapy and Targeted Therapy.
Yang H, Liu H, Zhang Y, Zhang Y, Chen Y
Clin Nucl Med 2024 Jun 1;49(6):569-571. Epub 2024 Apr 9 doi: 10.1097/RLU.0000000000005169. PMID: 38598734
Organ-specific heterogeneity in tumor-infiltrating immune cells and cancer antigen expression in primary and autologous metastatic lung adenocarcinoma.
Restle D, Dux J, Li X, Byun AJ, Choe JK, Li Y, Vaghjiani RG, Thomas C, Misawa K, Tan KS, Jones DR, Chintala NK, Adusumilli PS
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2022-006609. PMID: 37349126Free PMC Article
Rationale and Design of the Phase II ANTELOPE Study of Atezolizumab, Carboplatin and nab-Paclitaxel vs. Pembrolizumab, Platinum and Pemetrexed in TTF-1 Negative, Metastatic Lung Adenocarcinoma (AIO-TRK-0122).
Frost N, Bleckmann A, Griesinger F, Grohé C, Janning M, Kollmeier J, Reinmuth N, Sebastian M, Thomas M, Reck M
Clin Lung Cancer 2023 Sep;24(6):568-572. Epub 2023 Apr 23 doi: 10.1016/j.cllc.2023.04.009. PMID: 37169628
Pembrolizumab-induced acute right L5 neuritis unresponsive to steroids.
Fitzpatrick L, Lwin Z, Gericke C
BMJ Case Rep 2022 Nov 22;15(11) doi: 10.1136/bcr-2022-250971. PMID: 36414343Free PMC Article
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Jordan EJ, Kim HR, Arcila ME, Barron D, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu HA, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ
Cancer Discov 2017 Jun;7(6):596-609. Epub 2017 Mar 23 doi: 10.1158/2159-8290.CD-16-1337. PMID: 28336552Free PMC Article

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