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Recurrent Submandibular Gland Mucoepidermoid Carcinoma

MedGen UID:
1665754
•Concept ID:
C4727414
•
Neoplastic Process

Definition

The reemergence of submandibular gland mucoepidermoid carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Submandibular Gland Mucoepidermoid Carcinoma

Professional guidelines

PubMed

Management and outcome of patients with mucoepidermoid carcinoma of major salivary gland origin: a single institution's 30-year experience.
Aro K, Leivo I, Mäkitie AA
Laryngoscope 2008 Feb;118(2):258-62. doi: 10.1097/MLG.0b013e31815a6b0b. PMID: 18030166
Effect of initial treatment on disease outcome for patients with submandibular gland carcinoma.
Kaszuba SM, Zafereo ME, Rosenthal DI, El-Naggar AK, Weber RS
Arch Otolaryngol Head Neck Surg 2007 Jun;133(6):546-50. doi: 10.1001/archotol.133.6.546. PMID: 17576904
Management and outcome of patients with malignant salivary gland tumors.
Bell RB, Dierks EJ, Homer L, Potter BE
J Oral Maxillofac Surg 2005 Jul;63(7):917-28. doi: 10.1016/j.joms.2005.03.006. PMID: 16003616

Recent clinical studies

Etiology

The protective role of postoperative radiation therapy in low and intermediate grade major salivary gland malignancies: A study of the Canadian Head and Neck Collaborative Research Initiative.
Morand GB, Eskander A, Fu R, de Almeida J, Goldstein D, Noroozi H, Hosni A, Seikaly H, Tabet P, Pyne JM, Matthews TW, Dort J, Nakoneshny S, Christopoulos A, Bahig H, Johnson-Obaseki S, Hua N, Gaudet M, Jooya A, Nichols A, Laxague F, Cecchini M, Du J, Shapiro J, Karam I, Dziegielewski PT, Hanubal K, Erovic B, Grasl S, Davies J, Monteiro E, Gete M, Witterick I, Sadeghi N, Richardson K, Shenouda G, Maniakas A, Landry V, Gupta M, Zhou K, Mlynarek AM, Pusztaszeri M, Sultanem K, Hier MP
Cancer 2023 Oct 15;129(20):3263-3274. Epub 2023 Jul 4 doi: 10.1002/cncr.34932. PMID: 37401841
Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Submandibular salivary gland tumors: Clinical course and outcome of a 20-year multicenter study.
Mizrachi A, Bachar G, Unger Y, Hilly O, Fliss DM, Shpitzer T
Ear Nose Throat J 2017 Mar;96(3):E17-E20. doi: 10.1177/014556131709600320. PMID: 28346650
Distant metastases from salivary glands cancer.
Bradley PJ
ORL J Otorhinolaryngol Relat Spec 2001 Jul-Aug;63(4):233-42. doi: 10.1159/000055748. PMID: 11408820

Diagnosis

NUT carcinoma of the submandibular gland: A case report.
Rota S, Quattrone P, Centonze G, Dagrada G, Ottini A, Colombo E, Nuzzolese I, Calareso G, Franceschini M, Iacovelli NA, Perrone F, Tamborini E, Cavalieri S
Cancer Rep (Hoboken) 2023 Dec;6(12):e1900. Epub 2023 Sep 8 doi: 10.1002/cnr2.1900. PMID: 37680121Free PMC Article
Mucoepidermoid carcinoma: Analysis of 76 cytologic cases and correlation with histologic grade.
Wakely PE Jr
Cancer Cytopathol 2022 Oct;130(10):783-799. Epub 2022 May 31 doi: 10.1002/cncy.22600. PMID: 35640091
Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma.
Byrd SA, Spector ME, Carey TE, Bradford CR, McHugh JB
Otolaryngol Head Neck Surg 2013 Sep;149(3):402-8. Epub 2013 May 21 doi: 10.1177/0194599813489659. PMID: 23695589Free PMC Article

Therapy

Radiation-induced epithelial-myoepithelial carcinoma in a patient previously treated with mantle-field radiation therapy for Hodgkin lymphoma.
Mann JM, Kellman RM, Hahn SS, de la Roza GL, Gajra A
Head Neck 2015 Aug;37(8):E96-8. Epub 2015 May 26 doi: 10.1002/hed.23873. PMID: 25242451
Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy.
Schoenfeld JD, Sher DJ, Norris CM Jr, Haddad RI, Posner MR, Balboni TA, Tishler RB
Int J Radiat Oncol Biol Phys 2012 Jan 1;82(1):308-14. Epub 2010 Nov 13 doi: 10.1016/j.ijrobp.2010.09.042. PMID: 21075557
Mucoepidermoid carcinoma of the salivary gland.
Connell HC, Evans JC
Am J Surg 1972 Oct;124(4):519-21. doi: 10.1016/0002-9610(72)90078-5. PMID: 4342488

Prognosis

Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Mucoepidermoid carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Mack JW, Marcus KJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 May;120:93-99. Epub 2019 Feb 10 doi: 10.1016/j.ijporl.2019.02.020. PMID: 30772619
Survival in patients with submandibular gland carcinoma - Results of a multi-institutional retrospective study.
Yamada K, Honda K, Tamaki H, Tanaka S, Shinohara S, Takebayashi S, Tateya I, Kitamura M, Mizuta M, Maetani T, Kojima T, Kitani Y, Asato R, Ichimaru K, Kumabe Y, Ushiro K, Omori K
Auris Nasus Larynx 2018 Oct;45(5):1066-1072. Epub 2018 Feb 7 doi: 10.1016/j.anl.2018.01.011. PMID: 29428494
Submandibular salivary gland tumors: Clinical course and outcome of a 20-year multicenter study.
Mizrachi A, Bachar G, Unger Y, Hilly O, Fliss DM, Shpitzer T
Ear Nose Throat J 2017 Mar;96(3):E17-E20. doi: 10.1177/014556131709600320. PMID: 28346650
Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma.
Byrd SA, Spector ME, Carey TE, Bradford CR, McHugh JB
Otolaryngol Head Neck Surg 2013 Sep;149(3):402-8. Epub 2013 May 21 doi: 10.1177/0194599813489659. PMID: 23695589Free PMC Article

Clinical prediction guides

Mucoepidermoid carcinoma: Evaluating the prognostic impact of primary tumor site.
Mimica X, Yuan A, Hay A, Katabi N, Zanoni DK, Valero C, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2021 Dec;123:105602. Epub 2021 Nov 9 doi: 10.1016/j.oraloncology.2021.105602. PMID: 34768210Free PMC Article
Survival in patients with submandibular gland carcinoma - Results of a multi-institutional retrospective study.
Yamada K, Honda K, Tamaki H, Tanaka S, Shinohara S, Takebayashi S, Tateya I, Kitamura M, Mizuta M, Maetani T, Kojima T, Kitani Y, Asato R, Ichimaru K, Kumabe Y, Ushiro K, Omori K
Auris Nasus Larynx 2018 Oct;45(5):1066-1072. Epub 2018 Feb 7 doi: 10.1016/j.anl.2018.01.011. PMID: 29428494
Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period.
Granic M, Suton P, Mueller D, Cvrljevic I, Luksic I
Int J Oral Maxillofac Surg 2018 Mar;47(3):283-288. Epub 2017 Sep 29 doi: 10.1016/j.ijom.2017.09.005. PMID: 28969884
Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma.
Byrd SA, Spector ME, Carey TE, Bradford CR, McHugh JB
Otolaryngol Head Neck Surg 2013 Sep;149(3):402-8. Epub 2013 May 21 doi: 10.1177/0194599813489659. PMID: 23695589Free PMC Article
Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria.
Goode RK, Auclair PL, Ellis GL
Cancer 1998 Apr 1;82(7):1217-24. doi: 10.1002/(sici)1097-0142(19980401)82:7<1217::aid-cncr2>3.0.co;2-c. PMID: 9529011

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