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Castration-Naive Prostate Carcinoma

MedGen UID:
1667471
•Concept ID:
C4725110
•
Neoplastic Process
Synonym: Castration-Naive Prostate Cancer

Definition

Advanced prostatic carcinoma which was not previously treated with androgen-deprivation therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCastration-Naive Prostate Carcinoma

Professional guidelines

PubMed

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.
Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, Halabi S, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM, Beltran H, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Drake CG, Eeles RA, Fanti S, Gleave ME, Heidenreich A, Hussain M, James ND, Lecouvet FE, Logothetis CJ, Mastris K, Nilsson S, Oh WK, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B
Ann Oncol 2015 Aug;26(8):1589-604. Epub 2015 Jun 3 doi: 10.1093/annonc/mdv257. PMID: 26041764Free PMC Article

Recent clinical studies

Etiology

Shared Decision-Making for Patients with Advanced Urological Malignancies: Evaluation of a Joint Urological-Oncological Clinic Model.
Betschart P, Babst C, Schmid S, Rothermundt C, Abt D, Schwab C, Gillessen S, Engeler DS, Klingbiel D, Schmid HP, Omlin A
Oncol Res Treat 2019;42(7-8):366-374. Epub 2019 Jun 6 doi: 10.1159/000499721. PMID: 31170721

Diagnosis

Shared Decision-Making for Patients with Advanced Urological Malignancies: Evaluation of a Joint Urological-Oncological Clinic Model.
Betschart P, Babst C, Schmid S, Rothermundt C, Abt D, Schwab C, Gillessen S, Engeler DS, Klingbiel D, Schmid HP, Omlin A
Oncol Res Treat 2019;42(7-8):366-374. Epub 2019 Jun 6 doi: 10.1159/000499721. PMID: 31170721

Therapy

Shared Decision-Making for Patients with Advanced Urological Malignancies: Evaluation of a Joint Urological-Oncological Clinic Model.
Betschart P, Babst C, Schmid S, Rothermundt C, Abt D, Schwab C, Gillessen S, Engeler DS, Klingbiel D, Schmid HP, Omlin A
Oncol Res Treat 2019;42(7-8):366-374. Epub 2019 Jun 6 doi: 10.1159/000499721. PMID: 31170721
Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.
Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, Halabi S, Nelson PS, Sartor O, Smith MR, Soule HR, Akaza H, Beer TM, Beltran H, Chinnaiyan AM, Daugaard G, Davis ID, De Santis M, Drake CG, Eeles RA, Fanti S, Gleave ME, Heidenreich A, Hussain M, James ND, Lecouvet FE, Logothetis CJ, Mastris K, Nilsson S, Oh WK, Olmos D, Padhani AR, Parker C, Rubin MA, Schalken JA, Scher HI, Sella A, Shore ND, Small EJ, Sternberg CN, Suzuki H, Sweeney CJ, Tannock IF, Tombal B
Ann Oncol 2015 Aug;26(8):1589-604. Epub 2015 Jun 3 doi: 10.1093/annonc/mdv257. PMID: 26041764Free PMC Article
Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer.
De Velasco MA, Tanaka M, Yamamoto Y, Hatanaka Y, Koike H, Nishio K, Yoshikawa K, Uemura H
Carcinogenesis 2014 Sep;35(9):2142-53. Epub 2014 Jul 1 doi: 10.1093/carcin/bgu143. PMID: 24986896Free PMC Article

Prognosis

Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer.
De Velasco MA, Tanaka M, Yamamoto Y, Hatanaka Y, Koike H, Nishio K, Yoshikawa K, Uemura H
Carcinogenesis 2014 Sep;35(9):2142-53. Epub 2014 Jul 1 doi: 10.1093/carcin/bgu143. PMID: 24986896Free PMC Article

Clinical prediction guides

Androgen deprivation induces phenotypic plasticity and promotes resistance to molecular targeted therapy in a PTEN-deficient mouse model of prostate cancer.
De Velasco MA, Tanaka M, Yamamoto Y, Hatanaka Y, Koike H, Nishio K, Yoshikawa K, Uemura H
Carcinogenesis 2014 Sep;35(9):2142-53. Epub 2014 Jul 1 doi: 10.1093/carcin/bgu143. PMID: 24986896Free PMC Article

Supplemental Content

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