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Metastatic Adrenal Cortical Carcinoma

MedGen UID:
1667758
•Concept ID:
C4744547
•
Neoplastic Process
Synonym: Metastatic Adrenal Cortex Carcinoma

Definition

A carcinoma that arises from the adrenal cortex and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Adrenal Cortical Carcinoma

Professional guidelines

PubMed

Drugs in the medical treatment of Cushing's syndrome.
Schteingart DE
Expert Opin Emerg Drugs 2009 Dec;14(4):661-71. doi: 10.1517/14728210903413522. PMID: 19939210
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Schlumberger M, Brugieres L, Gicquel C, Travagli JP, Droz JP, Parmentier C
Cancer 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#. PMID: 2044046

Recent clinical studies

Etiology

Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Interpretation of core biopsy of liver mass lesions: A comparison study between cytopathologist and gastrointestinal pathologist.
Washburn ER, Yang Z
Ann Diagn Pathol 2019 Jun;40:152-160. Epub 2019 May 5 doi: 10.1016/j.anndiagpath.2019.05.001. PMID: 31100645
Adrenal cortical carcinoma: a case of late pulmonary metastasis.
Dang C, Mohamed H, Mandal A, Salem F
J Natl Med Assoc 2001 Jan;93(1):37-9. PMID: 12653379Free PMC Article
5-Fluorouracil, doxorubicin, and cisplatin as treatment for adrenal cortical carcinoma.
Schlumberger M, Brugieres L, Gicquel C, Travagli JP, Droz JP, Parmentier C
Cancer 1991 Jun 15;67(12):2997-3000. doi: 10.1002/1097-0142(19910615)67:12<2997::aid-cncr2820671211>3.0.co;2-#. PMID: 2044046
Prolonged survival following six pulmonary resections for metastatic adrenal cortical carcinoma: a case report.
Potter DA, Strott CA, Javadpour N, Roth JA
J Surg Oncol 1984 Apr;25(4):273-7. doi: 10.1002/jso.2930250411. PMID: 6201679

Diagnosis

A novel lynch syndrome kindred with hereditary adrenal cortical carcinoma.
Ahuja K, Goudar R
Cancer Genet 2024 Nov;288-289:137-140. Epub 2024 Nov 15 doi: 10.1016/j.cancergen.2024.11.005. PMID: 39571462
Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.
Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T, Mols-Kowalczewski B
J Adolesc Young Adult Oncol 2022 Feb;11(1):122-125. Epub 2021 May 12 doi: 10.1089/jayao.2020.0229. PMID: 33978483
Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Adrenal cortical carcinoma: a case of late pulmonary metastasis.
Dang C, Mohamed H, Mandal A, Salem F
J Natl Med Assoc 2001 Jan;93(1):37-9. PMID: 12653379Free PMC Article
Adrenal cortical carcinoma metastatic to the brain in a child.
Piniella AM, Siatkowski RM
J Neuroophthalmol 2000 Mar;20(1):35-7. doi: 10.1097/00041327-200020010-00012. PMID: 10770506

Therapy

Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
Metastatic Adrenal Cortical Carcinoma Responding to Octreotide: A Case Report.
Wang X, Zhou N, Xiao Y, Zhu W, Bai C, Zhao L
Oncologist 2019 Aug;24(8):e793-e797. Epub 2019 May 9 doi: 10.1634/theoncologist.2018-0855. PMID: 31073023Free PMC Article
CASE 2. Response in a patient with metastatic adrenal cortical carcinoma with thalidomide.
Chacón R, Tossen G, Loria FS, Chacón M
J Clin Oncol 2005 Mar 1;23(7):1579-80. doi: 10.1200/JCO.2005.03.195. PMID: 15735134
Metastatic adrenal cortical carcinoma: biochemical changes accompanying clinical regression during therapy with o,p'-DDD.
Helson L, Wollner N, Murphy ML, Schwartz MK
Clin Chem 1971 Dec;17(12):1191-3. PMID: 4330217
Testosterone and androstenedione production rates in patients with metastatic adrenal cortical carcinoma.
Bardin CW, Lipsett MB, French AM
J Clin Endocrinol Metab 1968 Feb;28(2):215-20. doi: 10.1210/jcem-28-2-215. PMID: 5636152

Prognosis

Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.
Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T, Mols-Kowalczewski B
J Adolesc Young Adult Oncol 2022 Feb;11(1):122-125. Epub 2021 May 12 doi: 10.1089/jayao.2020.0229. PMID: 33978483
Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma.
Huang R, Liu Z, Tian T, Song D, Yan P, Yin H, Hu P, Zhu X, Liu Y, Li Z, Meng T, Zhang J, Huang Z
Biosci Rep 2020 Mar 27;40(3) doi: 10.1042/BSR20200049. PMID: 32175564Free PMC Article
Adrenal cortical carcinoma: a case of late pulmonary metastasis.
Dang C, Mohamed H, Mandal A, Salem F
J Natl Med Assoc 2001 Jan;93(1):37-9. PMID: 12653379Free PMC Article
Prolonged survival following six pulmonary resections for metastatic adrenal cortical carcinoma: a case report.
Potter DA, Strott CA, Javadpour N, Roth JA
J Surg Oncol 1984 Apr;25(4):273-7. doi: 10.1002/jso.2930250411. PMID: 6201679

Clinical prediction guides

Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma.
Bedrose S, Miller KC, Altameemi L, Ali MS, Nassar S, Garg N, Daher M, Eaton KD, Yorio JT, Daniel DB, Campbell M, Bible KC, Ryder M, Chintakuntlawar AV, Habra MA
J Immunother Cancer 2020 Jul;8(2) doi: 10.1136/jitc-2020-001009. PMID: 32737143Free PMC Article
The construction and analysis of tumor-infiltrating immune cells and ceRNA networks in metastatic adrenal cortical carcinoma.
Huang R, Liu Z, Tian T, Song D, Yan P, Yin H, Hu P, Zhu X, Liu Y, Li Z, Meng T, Zhang J, Huang Z
Biosci Rep 2020 Mar 27;40(3) doi: 10.1042/BSR20200049. PMID: 32175564Free PMC Article
Spontaneously regressing adrenocortical carcinoma in a newborn. A case report with DNA ploidy analysis.
Saracco S, Abramowsky C, Taylor S, Silverman RA, Berman BW
Cancer 1988 Aug 1;62(3):507-11. doi: 10.1002/1097-0142(19880801)62:3<507::aid-cncr2820620311>3.0.co;2-8. PMID: 3390790
5-Fluorouracil, doxorubicin, and cisplatin regimen in adrenal cortical carcinoma.
Schlumberger M, Ostronoff M, Bellaiche M, Rougier P, Droz JP, Parmentier C
Cancer 1988 Apr 15;61(8):1492-4. doi: 10.1002/1097-0142(19880415)61:8<1492::aid-cncr2820610803>3.0.co;2-1. PMID: 3349416
CAP (cyclophosphamide, doxorubicin, and cisplatin) regimen in adrenal cortical carcinoma.
van Slooten H, van Oosterom AT
Cancer Treat Rep 1983 Apr;67(4):377-9. PMID: 6687835

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