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Abnormal circulating glutamate concentration

MedGen UID:
1670972
•Concept ID:
C4732902
•
Finding
Synonym: Abnormality of glutamate metabolism
 
HPO: HP:0500148

Definition

Any deviation from the normal concentration of glutamate in the blood circulation. [from HPO]

Recent clinical studies

Etiology

The Relationships between Dopaminergic, Glutamatergic, and Cognitive Functioning in 22q11.2 Deletion Syndrome: A Cross-Sectional, Multimodal (1)H-MRS and (18)F-Fallypride PET Study.
van Hooijdonk CFM, Tse DHY, Roosenschoon J, Ceccarini J, Booij J, van Amelsvoort TAMJ, Vingerhoets C
Genes (Basel) 2022 Sep 19;13(9) doi: 10.3390/genes13091672. PMID: 36140839Free PMC Article
Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
Free amino acid concentrations in normal and abnormal third trimester placental villi.
Morris NH, Burston D, Ramsay B, Sooranna SR
Eur J Clin Invest 1995 Oct;25(10):796-8. doi: 10.1111/j.1365-2362.1995.tb01960.x. PMID: 8557068
Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography.
Camici P, Ferrannini E, Opie LH
Prog Cardiovasc Dis 1989 Nov-Dec;32(3):217-38. doi: 10.1016/0033-0620(89)90027-3. PMID: 2682779

Diagnosis

Development and validation of a UPLC-MS/MS method for the simultaneous determination of gamma-aminobutyric acid and glutamic acid in human plasma.
de Bie TH, Witkamp RF, Jongsma MA, Balvers MGJ
J Chromatogr B Analyt Technol Biomed Life Sci 2021 Feb 1;1164:122519. Epub 2020 Dec 28 doi: 10.1016/j.jchromb.2020.122519. PMID: 33454439
Adipokines in children with sleep disordered breathing.
Tauman R, Serpero LD, Capdevila OS, O'Brien LM, Goldbart AD, Kheirandish-Gozal L, Gozal D
Sleep 2007 Apr;30(4):443-9. doi: 10.1093/sleep/30.4.443. PMID: 17520788
Brain imaging in idiopathic generalized epilepsies.
Duncan JS
Epilepsia 2005;46 Suppl 9:108-11. doi: 10.1111/j.1528-1167.2005.00321.x. PMID: 16302883
Regional cerebral blood flow and cerebrospinal fluid glutamate in leukoaraiosis.
Oishi M, Mochizuki Y
J Neurol 1998 Dec;245(12):777-80. doi: 10.1007/s004150050286. PMID: 9840349
Imaging and epilepsy.
Duncan JS
Brain 1997 Feb;120 ( Pt 2):339-77. doi: 10.1093/brain/120.2.339. PMID: 9117380

Therapy

Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity after Kidney Transplantation.
Lepping RJ, Montgomery RN, Sharma P, Mahnken JD, Vidoni ED, Choi IY, Sarnak MJ, Brooks WM, Burns JM, Gupta A
J Am Soc Nephrol 2021 Jan;32(1):177-187. Epub 2020 Oct 16 doi: 10.1681/ASN.2020050584. PMID: 33067382Free PMC Article
Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle.
Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep 2020 Jun 2;10(1):8930. doi: 10.1038/s41598-020-65852-x. PMID: 32488174Free PMC Article
Metabolic changes after cardiac surgery.
Jakob SM, Ensinger H, Takala J
Curr Opin Clin Nutr Metab Care 2001 Mar;4(2):149-55. doi: 10.1097/00075197-200103000-00012. PMID: 11224661
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation.
Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA
Eur J Appl Physiol Occup Physiol 1997;75(1):47-53. doi: 10.1007/s004210050125. PMID: 9007457
Acquired vitamin K-dependent carboxylation deficiency in liver disease.
Blanchard RA, Furie BC, Jorgensen M, Kruger SF, Furie B
N Engl J Med 1981 Jul 30;305(5):242-8. doi: 10.1056/NEJM198107303050502. PMID: 6165889

Prognosis

The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease.
Mayer O Jr, Seidlerová J, Vaněk J, Karnosová P, Bruthans J, Filipovský J, Wohlfahrt P, Cífková R, Windrichová J, Knapen MH, Drummen NE, Vermeer C
Int J Cardiol 2016 Jan 15;203:916-22. Epub 2015 Oct 31 doi: 10.1016/j.ijcard.2015.10.226. PMID: 26618253
Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encephalopathy.
Grover VP, Dresner MA, Forton DM, Counsell S, Larkman DJ, Patel N, Thomas HC, Taylor-Robinson SD
World J Gastroenterol 2006 May 21;12(19):2969-78. doi: 10.3748/wjg.v12.i19.2969. PMID: 16718775Free PMC Article
Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation.
Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA
Eur J Appl Physiol Occup Physiol 1997;75(1):47-53. doi: 10.1007/s004210050125. PMID: 9007457
Quantification of wear, hemolysis and coagulation deficits in patients with Beall mitral valves.
Clark RE, Pavlovic TA, Knight BE, Joist JH, Burrows SD, McKnight RC, Brown EB
Circulation 1977 Sep;56(3 Suppl):II139-43. PMID: 884818

Clinical prediction guides

Development and validation of a UPLC-MS/MS method for the simultaneous determination of gamma-aminobutyric acid and glutamic acid in human plasma.
de Bie TH, Witkamp RF, Jongsma MA, Balvers MGJ
J Chromatogr B Analyt Technol Biomed Life Sci 2021 Feb 1;1164:122519. Epub 2020 Dec 28 doi: 10.1016/j.jchromb.2020.122519. PMID: 33454439
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
Sookoian S, Castaño GO, Scian R, Fernández Gianotti T, Dopazo H, Rohr C, Gaj G, San Martino J, Sevic I, Flichman D, Pirola CJ
Am J Clin Nutr 2016 Feb;103(2):422-34. Epub 2016 Jan 20 doi: 10.3945/ajcn.115.118695. PMID: 26791191
The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease.
Mayer O Jr, Seidlerová J, Vaněk J, Karnosová P, Bruthans J, Filipovský J, Wohlfahrt P, Cífková R, Windrichová J, Knapen MH, Drummen NE, Vermeer C
Int J Cardiol 2016 Jan 15;203:916-22. Epub 2015 Oct 31 doi: 10.1016/j.ijcard.2015.10.226. PMID: 26618253
Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
Kakazu E, Ueno Y, Kondo Y, Inoue J, Ninomiya M, Kimura O, Wakui Y, Fukushima K, Tamai K, Shimosegawa T
PLoS One 2011;6(8):e23402. Epub 2011 Aug 17 doi: 10.1371/journal.pone.0023402. PMID: 21858100Free PMC Article
Myocardial metabolism in ischemic heart disease: basic principles and application to imaging by positron emission tomography.
Camici P, Ferrannini E, Opie LH
Prog Cardiovasc Dis 1989 Nov-Dec;32(3):217-38. doi: 10.1016/0033-0620(89)90027-3. PMID: 2682779

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