U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hypertensive renal disease(HNP1)

MedGen UID:
167258
•Concept ID:
C0848548
•
Disease or Syndrome
Synonyms: HNP1; HYPERTENSIVE NEPHROPATHY
SNOMED CT: Renal disease due to hypertension (38481006); Hypertensive renal disease (38481006); Hypertensive nephropathy (38481006)
 
Monarch Initiative: MONDO:0024633
OMIM®: 608026

Definition

Kidney damage that results from chronically elevated blood pressure; complications include glomerular damage resulting in proteinuria and hematuria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypertensive renal disease

Professional guidelines

PubMed

Current strategies for management of hypertensive renal disease.
Moore MA, Epstein M, Agodoa L, Dworkin LD
Arch Intern Med 1999 Jan 11;159(1):23-8. doi: 10.1001/archinte.159.1.23. PMID: 9892326
Diagnosis and management of vascular disease in systemic sclerosis.
Yost JH, Spencer-Green G
Compr Ther 1993;19(2):53-9. PMID: 8370246
Case-mix and treatment in end-stage renal disease: hemodialysis v peritoneal dialysis.
Radecki SE, Mendenhall RC, Nissenson AR, Freeman RB, Blagg CR, Capelli JP, Gentile DE, Feinstein EI
Am J Kidney Dis 1988 Jan;11(1):7-14. doi: 10.1016/s0272-6386(88)80167-7. PMID: 3122560

Recent clinical studies

Etiology

Mendelian and trans-generational inheritance in hypertensive renal disease.
Braun MC, Doris PA
Ann Med 2012 Jun;44 Suppl 1(Suppl 1):S65-73. doi: 10.3109/07853890.2012.665473. PMID: 22713151Free PMC Article
Genetic susceptibility to hypertensive renal disease.
Doris PA
Cell Mol Life Sci 2012 Nov;69(22):3751-63. Epub 2012 May 5 doi: 10.1007/s00018-012-0996-3. PMID: 22562581Free PMC Article
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group
JAMA 2002 Nov 20;288(19):2421-31. doi: 10.1001/jama.288.19.2421. PMID: 12435255
Nephrectomy: indications and complications in 347 patients.
Schiff M Jr, Glazier WB
J Urol 1977 Dec;118(6):930-1. doi: 10.1016/s0022-5347(17)58253-1. PMID: 926267

Diagnosis

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Susceptibility to Hypertensive Renal Disease in the Spontaneously Hypertensive Rat Is Influenced by 2 Loci Affecting Blood Pressure and Immunoglobulin Repertoire.
Dhande IS, Cranford SM, Zhu Y, Kneedler SC, Hicks MJ, Wenderfer SE, Braun MC, Doris PA
Hypertension 2018 Apr;71(4):700-708. Epub 2018 Feb 5 doi: 10.1161/HYPERTENSIONAHA.117.10593. PMID: 29437896Free PMC Article
The immune system: role in hypertension.
Schiffrin EL
Can J Cardiol 2013 May;29(5):543-8. Epub 2012 Aug 15 doi: 10.1016/j.cjca.2012.06.009. PMID: 22902155
Cardiac consequences of hypertension in hemodialysis patients.
Zoccali C, Benedetto FA, Tripepi G, Mallamaci F
Semin Dial 2004 Jul-Aug;17(4):299-303. doi: 10.1111/j.0894-0959.2004.17331.x. PMID: 15250922
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320

Therapy

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Prevention of the development and progression of renal disease.
Hostetter TH
J Am Soc Nephrol 2003 Jul;14(7 Suppl 2):S144-7. doi: 10.1097/01.asn.0000070150.60928.06. PMID: 12819320
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group
JAMA 2002 Nov 20;288(19):2421-31. doi: 10.1001/jama.288.19.2421. PMID: 12435255
Hypertension and endstage renal disease.
Brown TE, Carter BL
Ann Pharmacother 1994 Mar;28(3):359-66. doi: 10.1177/106002809402800312. PMID: 8193427
Carvedilol and the kidney.
Dupont AG
Clin Investig 1992;70 Suppl 1:S127-31. doi: 10.1007/BF00207623. PMID: 1350479

Prognosis

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Hypertension and kidney disease: a deadly connection.
Barri YM
Curr Hypertens Rep 2008 Feb;10(1):39-45. doi: 10.1007/s11906-008-0009-y. PMID: 18367025
Cardiac consequences of hypertension in hemodialysis patients.
Zoccali C, Benedetto FA, Tripepi G, Mallamaci F
Semin Dial 2004 Jul-Aug;17(4):299-303. doi: 10.1111/j.0894-0959.2004.17331.x. PMID: 15250922
Microalbuminuria in essential hypertension.
Mimran A, Ribstein J, Du Cailar G
Curr Opin Nephrol Hypertens 1999 May;8(3):359-63. doi: 10.1097/00041552-199905000-00014. PMID: 10456269
Pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome.
Settergren B, Ahlm C, Alexeyev O, Billheden J, Stegmayr B
Ren Fail 1997 Jan;19(1):1-14. doi: 10.3109/08860229709026255. PMID: 9044447

Clinical prediction guides

Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics.
Xu X, Eales JM, Jiang X, Sanderson E, Drzal M, Saluja S, Scannali D, Williams B, Morris AP, Guzik TJ, Charchar FJ, Holmes MV, Tomaszewski M
Cardiovasc Res 2022 Dec 9;118(15):3151-3161. doi: 10.1093/cvr/cvab357. PMID: 34893803Free PMC Article
Genetic susceptibility to hypertensive renal disease.
Doris PA
Cell Mol Life Sci 2012 Nov;69(22):3751-63. Epub 2012 May 5 doi: 10.1007/s00018-012-0996-3. PMID: 22562581Free PMC Article
The renin-angiotensin system in glomerular podocytes: mediator of glomerulosclerosis and link to hypertensive nephropathy.
Durvasula RV, Shankland SJ
Curr Hypertens Rep 2006 May;8(2):132-8. doi: 10.1007/s11906-006-0009-8. PMID: 16672146
Cardiac consequences of hypertension in hemodialysis patients.
Zoccali C, Benedetto FA, Tripepi G, Mallamaci F
Semin Dial 2004 Jul-Aug;17(4):299-303. doi: 10.1111/j.0894-0959.2004.17331.x. PMID: 15250922
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial.
Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Charleston J, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG; African American Study of Kidney Disease and Hypertension Study Group
JAMA 2002 Nov 20;288(19):2421-31. doi: 10.1001/jama.288.19.2421. PMID: 12435255

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...