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Vascular Hemorrhagic Disorder

MedGen UID:
167269
•Concept ID:
C0851563
•
Disease or Syndrome

Definition

A hemorrhagic disorder that is caused by pathologic changes in the vasculature. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVascular Hemorrhagic Disorder

Professional guidelines

PubMed

Post-stroke Movement Disorders: Clinical Spectrum, Pathogenesis, and Management.
Tater P, Pandey S
Neurol India 2021 Mar-Apr;69(2):272-283. doi: 10.4103/0028-3886.314574. PMID: 33904435
Disseminated intravascular coagulation: epidemiology, biomarkers, and management.
Adelborg K, Larsen JB, Hvas AM
Br J Haematol 2021 Mar;192(5):803-818. Epub 2021 Feb 8 doi: 10.1111/bjh.17172. PMID: 33555051
Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.
Faughnan ME, Mager JJ, Hetts SW, Palda VA, Lang-Robertson K, Buscarini E, Deslandres E, Kasthuri RS, Lausman A, Poetker D, Ratjen F, Chesnutt MS, Clancy M, Whitehead KJ, Al-Samkari H, Chakinala M, Conrad M, Cortes D, Crocione C, Darling J, de Gussem E, Derksen C, Dupuis-Girod S, Foy P, Geisthoff U, Gossage JR, Hammill A, Heimdal K, Henderson K, Iyer VN, Kjeldsen AD, Komiyama M, Korenblatt K, McDonald J, McMahon J, McWilliams J, Meek ME, Mei-Zahav M, Olitsky S, Palmer S, Pantalone R, Piccirillo JF, Plahn B, Porteous MEM, Post MC, Radovanovic I, Rochon PJ, Rodriguez-Lopez J, Sabba C, Serra M, Shovlin C, Sprecher D, White AJ, Winship I, Zarrabeitia R
Ann Intern Med 2020 Dec 15;173(12):989-1001. Epub 2020 Sep 8 doi: 10.7326/M20-1443. PMID: 32894695

Recent clinical studies

Etiology

Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
Pseudoxanthoma elasticum.
Germain DP
Orphanet J Rare Dis 2017 May 10;12(1):85. doi: 10.1186/s13023-017-0639-8. PMID: 28486967Free PMC Article
Pulmonary vascular diseases.
Cummings KW, Bhalla S
Clin Chest Med 2015 Jun;36(2):235-48, viii. Epub 2015 Mar 26 doi: 10.1016/j.ccm.2015.02.007. PMID: 26024602
The Ehlers-Danlos syndrome.
Malfait F, De Paepe A
Adv Exp Med Biol 2014;802:129-43. doi: 10.1007/978-94-007-7893-1_9. PMID: 24443025
Ehlers-Danlos syndrome--a historical review.
Parapia LA, Jackson C
Br J Haematol 2008 Apr;141(1):32-5. doi: 10.1111/j.1365-2141.2008.06994.x. PMID: 18324963

Diagnosis

Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
A diagnostic approach to mild bleeding disorders.
Boender J, Kruip MJ, Leebeek FW
J Thromb Haemost 2016 Aug;14(8):1507-16. Epub 2016 Jun 27 doi: 10.1111/jth.13368. PMID: 27208505
Cryoglobulinemia (review).
Takada S, Shimizu T, Hadano Y, Matsumoto K, Kataoka Y, Arima Y, Inoue T, Sorano S
Mol Med Rep 2012 Jul;6(1):3-8. Epub 2012 Apr 6 doi: 10.3892/mmr.2012.861. PMID: 22484457
Hereditary haemorrhagic telangiectasia.
Sharathkumar AA, Shapiro A
Haemophilia 2008 Nov;14(6):1269-80. doi: 10.1111/j.1365-2516.2008.01774.x. PMID: 19141168
Cutaneous pseudovasculitis.
Carlson JA, Chen KR
Am J Dermatopathol 2007 Feb;29(1):44-55. doi: 10.1097/01.dad.0000245195.35106.3c. PMID: 17284961

Therapy

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future.
Parums DV
Med Sci Monit 2024 Jan 28;30:e943912. doi: 10.12659/MSM.943912. PMID: 38281080Free PMC Article
Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.
Ozelo MC, Mahlangu J, Pasi KJ, Giermasz A, Leavitt AD, Laffan M, Symington E, Quon DV, Wang JD, Peerlinck K, Pipe SW, Madan B, Key NS, Pierce GF, O'Mahony B, Kaczmarek R, Henshaw J, Lawal A, Jayaram K, Huang M, Yang X, Wong WY, Kim B; GENEr8-1 Trial Group
N Engl J Med 2022 Mar 17;386(11):1013-1025. doi: 10.1056/NEJMoa2113708. PMID: 35294811
Disseminated intravascular coagulation: epidemiology, biomarkers, and management.
Adelborg K, Larsen JB, Hvas AM
Br J Haematol 2021 Mar;192(5):803-818. Epub 2021 Feb 8 doi: 10.1111/bjh.17172. PMID: 33555051
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
von Willebrand factor regulation of blood vessel formation.
Randi AM, Smith KE, Castaman G
Blood 2018 Jul 12;132(2):132-140. Epub 2018 Jun 4 doi: 10.1182/blood-2018-01-769018. PMID: 29866817Free PMC Article

Prognosis

Hereditary hemorrhagic telangiectasia (HHT): a practical guide to management.
Hammill AM, Wusik K, Kasthuri RS
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):469-477. doi: 10.1182/hematology.2021000281. PMID: 34889398Free PMC Article
Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches.
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G, Jansen F
J Mol Med (Berl) 2021 Mar;99(3):335-348. Epub 2021 Jan 22 doi: 10.1007/s00109-021-02037-7. PMID: 33481059Free PMC Article
Cryoglobulinemia (review).
Takada S, Shimizu T, Hadano Y, Matsumoto K, Kataoka Y, Arima Y, Inoue T, Sorano S
Mol Med Rep 2012 Jul;6(1):3-8. Epub 2012 Apr 6 doi: 10.3892/mmr.2012.861. PMID: 22484457
Single-organ vasculitis.
Hernández-Rodríguez J, Molloy ES, Hoffman GS
Curr Opin Rheumatol 2008 Jan;20(1):40-6. doi: 10.1097/BOR.0b013e3282f176a0. PMID: 18281856
Essential thrombocythemia.
Finazzi G, Harrison C
Semin Hematol 2005 Oct;42(4):230-8. doi: 10.1053/j.seminhematol.2005.05.022. PMID: 16210036

Clinical prediction guides

How we manage haemostasis during sepsis.
Scully M, Levi M
Br J Haematol 2019 Apr;185(2):209-218. Epub 2019 Mar 3 doi: 10.1111/bjh.15821. PMID: 30828800
A diagnostic approach to mild bleeding disorders.
Boender J, Kruip MJ, Leebeek FW
J Thromb Haemost 2016 Aug;14(8):1507-16. Epub 2016 Jun 27 doi: 10.1111/jth.13368. PMID: 27208505
Single-organ vasculitis.
Hernández-Rodríguez J, Molloy ES, Hoffman GS
Curr Opin Rheumatol 2008 Jan;20(1):40-6. doi: 10.1097/BOR.0b013e3282f176a0. PMID: 18281856
Shwartzman reaction.
Brozna JP
Semin Thromb Hemost 1990 Oct;16(4):326-32. doi: 10.1055/s-2007-1002685. PMID: 2281321
Essential thrombocythaemia.
Tobelem G
Baillieres Clin Haematol 1989 Jul;2(3):719-28. doi: 10.1016/s0950-3536(89)80040-x. PMID: 2505875

Recent systematic reviews

Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis.
Misra S, Kasner SE, Dawson J, Tanaka T, Zhao Y, Zaveri HP, Eldem E, Vazquez J, Silva LS, Mohidat S, Hickman LB, Khan EI, Funaro MC, Nicolo JP, Mazumder R, Yasuda CL, Sunnerhagen KS, Ihara M, Ross JS, Liebeskind DS, Kwan P, Quinn TJ, Engel J Jr, Mishra NK
JAMA Neurol 2023 Nov 1;80(11):1155-1165. doi: 10.1001/jamaneurol.2023.3240. PMID: 37721736Free PMC Article
Hypertensive primary intraventricular hemorrhage: a systematic review.
Robles LA, Volovici V
Neurosurg Rev 2022 Jun;45(3):2013-2026. Epub 2022 Feb 20 doi: 10.1007/s10143-022-01758-8. PMID: 35184233
Incidence and mortality rates of intracranial hemorrhage in hemophilia: a systematic review and meta-analysis.
Zwagemaker AF, Gouw SC, Jansen JS, Vuong C, Coppens M, Hu Q, Feng X, Kim SK, Van der Bom JG, Fijnvandraat K
Blood 2021 Dec 30;138(26):2853-2873. doi: 10.1182/blood.2021011849. PMID: 34411236
The Role of TEG and ROTEM in Damage Control Resuscitation.
Brill JB, Brenner M, Duchesne J, Roberts D, Ferrada P, Horer T, Kauvar D, Khan M, Kirkpatrick A, Ordonez C, Perreira B, Priouzram A, Cotton BA
Shock 2021 Dec 1;56(1S):52-61. doi: 10.1097/SHK.0000000000001686. PMID: 33769424Free PMC Article
Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review.
D'hondt S, Van Damme T, Malfait F
Genet Med 2018 Jun;20(6):562-573. Epub 2017 Oct 5 doi: 10.1038/gim.2017.138. PMID: 28981071Free PMC Article

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