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Breast Histiocytoid Carcinoma

MedGen UID:
1672725
Concept ID:
C4761423
Neoplastic Process
Synonyms: Histiocytoid Breast Carcinoma; Histiocytoid Lobular Breast Carcinoma; Infiltrating Histiocytoid Breast Carcinoma; Infiltrating Histiocytoid Lobular Breast Carcinoma; Invasive Histiocytoid Breast Carcinoma; Invasive Histiocytoid Lobular Breast Carcinoma

Definition

A rare variant of invasive lobular breast carcinoma characterized by the presence of histiocyte-like malignant cells with pale cytoplasm forming sheets or linear patterns. Apocrine differentiation may be present. It usually has an aggressive clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Histiocytoid Carcinoma

Recent clinical studies

Etiology

Coty-Fattal Z, Minhas S, Butcher M, Agarwal I, LaBoy C, Blanco L, Novo J
Int J Surg Pathol 2024 Jun;32(4):719-725. Epub 2023 Jul 31 doi: 10.1177/10668969231189714. PMID: 37525567
Wang Y, Hacking SM, Li Z, Graff SL, Yang D, Tan L, Liu F, Zhang T, Zhao Z, Luo S, Du P, Jia S, Cheng L
Am J Surg Pathol 2023 Sep 1;47(9):1011-1018. Epub 2023 Jun 13 doi: 10.1097/PAS.0000000000002073. PMID: 37310016
Murali R, Salisbury E, Pathmanathan N
Acta Cytol 2006 Sep-Oct;50(5):548-52. doi: 10.1159/000326013. PMID: 17017444
Gupta D, Croitoru CM, Ayala AG, Sahin AA, Middleton LP
Ann Diagn Pathol 2002 Jun;6(3):141-7. doi: 10.1053/adpa.2002.33880. PMID: 12089723
Eusebi V, Foschini MP, Bussolati G, Rosen PP
Am J Surg Pathol 1995 May;19(5):553-62. doi: 10.1097/00000478-199505000-00007. PMID: 7726365

Diagnosis

Wang Y, Hacking SM, Li Z, Graff SL, Yang D, Tan L, Liu F, Zhang T, Zhao Z, Luo S, Du P, Jia S, Cheng L
Am J Surg Pathol 2023 Sep 1;47(9):1011-1018. Epub 2023 Jun 13 doi: 10.1097/PAS.0000000000002073. PMID: 37310016
Cheah AL, Billings SD, Rowe JJ
Pathology 2016 Aug;48(5):406-24. Epub 2016 Jun 16 doi: 10.1016/j.pathol.2016.05.006. PMID: 27318503
Tan PH, Harada O, Thike AA, Tse GM
J Clin Pathol 2011 Aug;64(8):654-9. Epub 2011 Mar 12 doi: 10.1136/jcp.2011.088930. PMID: 21398688
Shimizu S, Kitamura H, Ito T, Nakamura T, Fujisawa J, Matsukawa H
Pathol Int 1998 Jul;48(7):549-56. doi: 10.1111/j.1440-1827.1998.tb03948.x. PMID: 9701019
Cameselle-Teijeiro J, Alfonsín-Barreiro N, Allegue F, Caeiro M
Pathol Res Pract 1997;193(10):713-20; discussion 721-22. doi: 10.1016/s0344-0338(97)80031-3. PMID: 9505264

Therapy

Wang Y, Hacking SM, Li Z, Graff SL, Yang D, Tan L, Liu F, Zhang T, Zhao Z, Luo S, Du P, Jia S, Cheng L
Am J Surg Pathol 2023 Sep 1;47(9):1011-1018. Epub 2023 Jun 13 doi: 10.1097/PAS.0000000000002073. PMID: 37310016
Lemos LB, Qu Z, Garg K, Papasozomenos S
Ann Diagn Pathol 2004 Oct;8(5):299-304. doi: 10.1016/j.anndiagpath.2004.07.009. PMID: 15494938

Prognosis

Coty-Fattal Z, Minhas S, Butcher M, Agarwal I, LaBoy C, Blanco L, Novo J
Int J Surg Pathol 2024 Jun;32(4):719-725. Epub 2023 Jul 31 doi: 10.1177/10668969231189714. PMID: 37525567
Berdugo J, Dumont-Mackay V, Brissy-Lachery S, Leclerc YE, Doyon J, Mitchell A, Petrella T, Désy D
Am J Dermatopathol 2017 Jun;39(6):e76-e78. doi: 10.1097/DAD.0000000000000810. PMID: 28525910
Kasashima S, Kawashima A, Zen Y, Ozaki S, Kobayashi M, Tsujibata A, Minato H
Virchows Arch 2007 Apr;450(4):397-403. Epub 2007 Feb 28 doi: 10.1007/s00428-007-0381-z. PMID: 17333267
Gupta D, Croitoru CM, Ayala AG, Sahin AA, Middleton LP
Ann Diagn Pathol 2002 Jun;6(3):141-7. doi: 10.1053/adpa.2002.33880. PMID: 12089723
Shimizu S, Kitamura H, Ito T, Nakamura T, Fujisawa J, Matsukawa H
Pathol Int 1998 Jul;48(7):549-56. doi: 10.1111/j.1440-1827.1998.tb03948.x. PMID: 9701019

Clinical prediction guides

Ito Y, Ishida M, Ohe C, Miyasaka C, Tsuta K
J Cutan Pathol 2021 Jan;48(1):102-105. Epub 2020 Sep 30 doi: 10.1111/cup.13838. PMID: 32770562
Mir F, Alnajar H, Rohra P, Naumaan A, Cheng L, Gattuso P
Diagn Cytopathol 2019 Mar;47(3):226-229. Epub 2018 Dec 27 doi: 10.1002/dc.24060. PMID: 30589232
Li P, Zheng J, Zhang T, Cao R, Chen X, Geng M
Int J Clin Exp Pathol 2013;6(11):2609-14. Epub 2013 Oct 15 PMID: 24228128Free PMC Article
Fujiwara M, Horiguchi M, Mori S, Yokoyama K, Horiguchi H, Fukazawa M, Fujiwara H, Yano Y, Satoh H, Kamma H
Pathol Int 2005 Jun;55(6):353-9. doi: 10.1111/j.1440-1827.2005.01836.x. PMID: 15943793
Kern SB, Andera L
Acta Cytol 1997 Mar-Apr;41(2):556-60. doi: 10.1159/000332556. PMID: 9100798

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