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Resectable Pancreatic Carcinoma

MedGen UID:
167709
•Concept ID:
C0854778
•
Neoplastic Process
Synonyms: Pancreatic Carcinoma, Resectable; Resectable Carcinoma of Pancreas; Resectable Carcinoma of the Pancreas; Resectable Pancreas Carcinoma; Resectable Pancreatic Cancer

Definition

Carcinoma of the pancreas amenable to surgical removal. [from NCI]

Professional guidelines

PubMed

Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Neoadjuvant strategy as initial treatment in resectable pancreatic cancer: concrete evidence of benefit.
DE Felice F, Musio D, Raffetto N, Tombolini V
Anticancer Res 2014 Sep;34(9):4673-6. PMID: 25202043
An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma.
Stojadinovic A, Brooks A, Hoos A, Jaques DP, Conlon KC, Brennan MF
J Am Coll Surg 2003 Jun;196(6):954-64. doi: 10.1016/S1072-7515(03)00010-3. PMID: 12788434

Recent clinical studies

Etiology

Comparison of neoadjuvant treatment and surgery first for resectable or borderline resectable pancreatic carcinoma: A systematic review and network meta-analysis of randomized controlled trials.
Huan L, Yu F, Cao D, Zhou H, Qin M, Cao Y
PLoS One 2024;19(3):e0295983. Epub 2024 Mar 7 doi: 10.1371/journal.pone.0295983. PMID: 38451955Free PMC Article
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients.
Yang J, Xu Z, Zhang J, Zheng Y, Gu J, Zhou Q, Wang X, Guo S, Zhang H, Chen S, Wang H
Med Sci Monit 2022 Nov 21;28:e938443. doi: 10.12659/MSM.938443. PMID: 36404606Free PMC Article
Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Neoadjuvant strategy as initial treatment in resectable pancreatic cancer: concrete evidence of benefit.
DE Felice F, Musio D, Raffetto N, Tombolini V
Anticancer Res 2014 Sep;34(9):4673-6. PMID: 25202043
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Diagnosis

Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities.
Manrai M, Tilak TVSVGK, Dawra S, Srivastava S, Singh A
World J Gastroenterol 2021 Oct 21;27(39):6572-6589. doi: 10.3748/wjg.v27.i39.6572. PMID: 34754153Free PMC Article
Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Knowing Your Boundaries: A Review of the Definitions and Imaging Features of Borderline Resectable Pancreatic Carcinoma.
McDonald N, Ahmad S, Ann Choe K
Semin Roentgenol 2016 Apr;51(2):82-7. Epub 2016 Feb 2 doi: 10.1053/j.ro.2016.02.001. PMID: 27105962
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306
The diagnosis of the small resectable pancreatic carcinoma.
Ariyama J, Shirakabe H, Ikenobe H, Kurosawa A, Owman T
Clin Radiol 1977 Jul;28(4):437-44. doi: 10.1016/s0009-9260(77)80160-8. PMID: 872510

Therapy

Comparison of neoadjuvant treatment and surgery first for resectable or borderline resectable pancreatic carcinoma: A systematic review and network meta-analysis of randomized controlled trials.
Huan L, Yu F, Cao D, Zhou H, Qin M, Cao Y
PLoS One 2024;19(3):e0295983. Epub 2024 Mar 7 doi: 10.1371/journal.pone.0295983. PMID: 38451955Free PMC Article
Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Phase I Study of Nab-Paclitaxel plus Gemcitabine as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer.
Okada KI, Hirono S, Kawai M, Miyazawa M, Shimizu A, Kitahata Y, Ueno M, Hayami S, Yamaue H
Anticancer Res 2017 Feb;37(2):853-858. doi: 10.21873/anticanres.11389. PMID: 28179342
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Prognosis

Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients.
Yang J, Xu Z, Zhang J, Zheng Y, Gu J, Zhou Q, Wang X, Guo S, Zhang H, Chen S, Wang H
Med Sci Monit 2022 Nov 21;28:e938443. doi: 10.12659/MSM.938443. PMID: 36404606Free PMC Article
Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities.
Manrai M, Tilak TVSVGK, Dawra S, Srivastava S, Singh A
World J Gastroenterol 2021 Oct 21;27(39):6572-6589. doi: 10.3748/wjg.v27.i39.6572. PMID: 34754153Free PMC Article
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma.
Wang HC, Meng QC, Shan ZZ, Yuan Z, Huang XY
Asian Pac J Cancer Prev 2015;16(4):1397-401. doi: 10.7314/apjcp.2015.16.4.1397. PMID: 25743805
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Clinical prediction guides

Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma.
Cao J, Fu Z, Gao L, Wang X, Cheng S, Wang X, Ren H
World J Surg Oncol 2017 Feb 20;15(1):48. doi: 10.1186/s12957-017-1104-9. PMID: 28219450Free PMC Article
Endoscopic ultrasonography complements computed tomography in predicting portal or superior mesenteric vein resection in patients with borderline resectable pancreatic carcinoma.
Glazer ES, Rashid OM, Klapman JB, Harris CL, Hodul PJ, Pimiento JM, Malafa MP
Pancreatology 2017 Jan-Feb;17(1):130-134. Epub 2016 Dec 5 doi: 10.1016/j.pan.2016.12.001. PMID: 28043760
Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma.
Wang HC, Meng QC, Shan ZZ, Yuan Z, Huang XY
Asian Pac J Cancer Prev 2015;16(4):1397-401. doi: 10.7314/apjcp.2015.16.4.1397. PMID: 25743805
Chemotherapy in pancreatic adenocarcinoma.
Squadroni M, Fazio N
Eur Rev Med Pharmacol Sci 2010 Apr;14(4):386-94. PMID: 20496553
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

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