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Composite Paraganglioma

MedGen UID:
1677462
•Concept ID:
C4763506
•
Neoplastic Process
Synonyms: Composite paraganglioma; Composite Pheochromocytoma and Paraganglioma; Composite Pheochromocytoma/Paraganglioma
SNOMED CT: Composite paraganglioma (817953005)

Definition

A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor. [from NCI]

Professional guidelines

PubMed

Impact of body composition and genotype on haemodynamics during surgery for pheochromocytoma and paraganglioma.
Pang Y, Li M, Jiang J, Chen X, Fu Y, Wang C, He Y, Zhao Y, Wang Y, Guan X, Zhang L, Xu X, Gan Y, Liu Y, Xie Y, Tang T, Wang J, Xie B, Liang Z, Chen D, Liu H, Chen C, Eisenhofer G, Liu L, Yi X, Chen BT
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2843-2853. Epub 2022 Sep 6 doi: 10.1002/jcsm.13071. PMID: 36068986Free PMC Article
Utility of GATA3 in the differential diagnosis of pheochromocytoma.
Perrino CM, Ho A, Dall CP, Zynger DL
Histopathology 2017 Sep;71(3):475-479. Epub 2017 Jun 5 doi: 10.1111/his.13229. PMID: 28374498
Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments.
Papathomas TG, de Krijger RR, Tischler AS
Semin Diagn Pathol 2013 Aug;30(3):207-23. doi: 10.1053/j.semdp.2013.06.006. PMID: 24144290

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311

Diagnosis

Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review.
Sasaki Y, Kanzawa M, Yamamoto M, Kanie K, Bando H, Yoshino K, Hirota Y, Shigemura K, Fujisawa M, Ogawa W, Fukuoka H
Endocr J 2024 Jan 29;71(1):65-74. Epub 2023 Nov 11 doi: 10.1507/endocrj.EJ23-0271. PMID: 37952980
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Composite Paraganglioma: Pioneering in the Head and Neck.
Delgado S, Smith SM, Mehra S, Prasad ML
Int J Surg Pathol 2019 May;27(3):282-289. Epub 2018 Sep 16 doi: 10.1177/1066896918799940. PMID: 30222023
Composite paraganglioma and ganglioneuroma in the retroperitoneum: a case report.
Ohtsuki Y, Watanabe R, Okada Y, Matsuka Y, Lee GH, Furihata M
Med Mol Morphol 2012 Jun;45(3):168-72. Epub 2012 Sep 22 doi: 10.1007/s00795-011-0567-y. PMID: 23001299
Adrenal and extra-adrenal nonfunctioning composite pheochromocytoma/paraganglioma with immunohistochemical ectopic hormone expression: comparison of two cases.
Gong J, Wang X, Chen X, Chen N, Huang R, Lu C, Chen D, Zeng H, Zhou Q
Urol Int 2010;85(3):368-72. Epub 2010 Sep 9 doi: 10.1159/000317312. PMID: 20829582

Prognosis

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Composite paraganglioma-ganglioneuroma of the urinary bladder.
Usuda H, Emura I
Pathol Int 2005 Sep;55(9):596-601. doi: 10.1111/j.1440-1827.2005.01875.x. PMID: 16143037

Clinical prediction guides

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Pigmented composite paraganglioma-ganglioneuroma of the urinary bladder.
Dundr P, Dudorkinová D, Povýsil C, Pesl M, Babjuk M, Dvorácek J, Zelinka T
Pathol Res Pract 2003;199(11):765-9. doi: 10.1078/0344-0338-00495. PMID: 14708645

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